8XQS
 
 | | Structure of human class T GPCR TAS2R14-DNGi complex with Flufenamic acid. | | Descriptor: | 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, CHOLESTEROL, Exo-alpha-sialidase,Taste receptor type 2 member 14,LgBiT, ... | | Authors: | Hu, X.L, Wu, L.J, Hua, T, Liu, Z.J. | | Deposit date: | 2024-01-05 | | Release date: | 2024-07-10 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.
Nature, 631, 2024
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4Q7W
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8XVI
 | | Cryo-EM structure of ETAR bound with Endothelin1 | | Descriptor: | Endoglucanase H,Endothelin-1 receptor, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | | Deposit date: | 2024-01-15 | | Release date: | 2024-08-28 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Structural basis of antagonist selectivity in endothelin receptors.
Cell Discov, 10, 2024
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8XVH
 | | Cryo-EM structure of ETBR bound with Endothelin1 | | Descriptor: | Endothelin-1, Exo-alpha-sialidase,Endothelin receptor type B, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | | Deposit date: | 2024-01-15 | | Release date: | 2024-08-28 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Structural basis of antagonist selectivity in endothelin receptors.
Cell Discov, 10, 2024
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8XVE
 | | Cryo-EM structure of ETBR bound with BQ3020 | | Descriptor: | BQ3020, Exo-alpha-sialidase,Endothelin receptor type B, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Hou, J.Y, Liu, S.H, Wu, L.J, Liu, Z.J, Hua, T. | | Deposit date: | 2024-01-15 | | Release date: | 2024-08-28 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis of antagonist selectivity in endothelin receptors.
Cell Discov, 10, 2024
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8G1E
 | | Structure of ACLY-D1026A-products-asym | | Descriptor: | (3S)-citryl-Coenzyme A, ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ... | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2023-02-02 | | Release date: | 2023-05-10 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Nat Commun, 14, 2023
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8Y53
 | | Cryo-EM structure of the MK-5046-bound BRS3-Gq complex | | Descriptor: | (2~{S})-1,1,1-tris(fluoranyl)-2-(4-pyrazol-1-ylphenyl)-3-[5-[[1-(trifluoromethyl)cyclopropyl]methyl]-1~{H}-imidazol-2-yl]propan-2-ol, Bombesin receptor subtype-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Li, C, Xu, Y, Yin, W, Xu, H.E. | | Deposit date: | 2024-01-31 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Structural insights into ligand recognition, selectivity, and activation of bombesin receptor subtype-3.
Cell Rep, 43, 2024
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8Y52
 | | Cryo-EM structure of the BA1-bound BRS3-Gq complex | | Descriptor: | BA1, Bombesin receptor subtype-3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Li, C, Xu, Y, Yin, W, Xu, H.E. | | Deposit date: | 2024-01-31 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural insights into ligand recognition, selectivity, and activation of bombesin receptor subtype-3.
Cell Rep, 43, 2024
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4QGC
 | | crystal structure of PKM2-K422R mutant | | Descriptor: | GLYCEROL, POTASSIUM ION, Pyruvate kinase PKM, ... | | Authors: | Wang, P, Sun, C, Zhu, T, Xu, Y. | | Deposit date: | 2014-05-22 | | Release date: | 2015-02-25 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.296 Å) | | Cite: | Structural insight into mechanisms for dynamic regulation of PKM2.
Protein Cell, 6, 2015
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8XWP
 | | Cryo-EM structure of ET-1 bound ETBR-DNGI complex | | Descriptor: | Endothelin receptor type B, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Tani, K, Maki-Yonekura, S, Kanno, R, Negami, T, Hamaguchi, T, Hall, M, Mizoguchi, A, Humbel, B.M, Terada, T, Yonekura, K, Doi, T. | | Deposit date: | 2024-01-16 | | Release date: | 2024-10-02 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structure of endothelin ET B receptor-G i complex in a conformation stabilized by unique NPxxL motif.
Commun Biol, 7, 2024
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4PYX
 | | Crystal structure of human carbonic anhydrase isozyme II with inhibitor | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)sulfanyl]benzenesulfonamide, Carbonic anhydrase 2, ... | | Authors: | Smirnov, A, Manakova, E, Grazulis, S. | | Deposit date: | 2014-03-28 | | Release date: | 2015-01-28 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.
J.Med.Chem., 57, 2014
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8XWQ
 | | Cryo-EM structure of ET-1 bound ETBR-DNGI complex | | Descriptor: | Endothelin receptor type B, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Tani, K, Maki-Yonekura, S, Kanno, R, Negami, T, Hamaguchi, T, Hall, M, Mizoguchi, A, Humbel, B.M, Terada, T, Yonekura, K, Doi, T. | | Deposit date: | 2024-01-16 | | Release date: | 2024-10-02 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structure of endothelin ET B receptor-G i complex in a conformation stabilized by unique NPxxL motif.
Commun Biol, 7, 2024
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8XOS
 | | Cryo-EM structure of the tethered agonist-bound human PAR1-Gi complex | | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Guo, J, Zhang, Y. | | Deposit date: | 2024-01-02 | | Release date: | 2024-09-18 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of tethered agonism and G protein coupling of protease-activated receptors.
Cell Res., 34, 2024
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8YIC
 | | SAR247799-bound S1PR1-Gi protein complex | | Descriptor: | Endolysin,Sphingosine 1-phosphate receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Xu, Z, Yu, J.J, Shao, Z.H. | | Deposit date: | 2024-02-29 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | SAR247799-bound S1PR1 in complex with Gi heterotrimer
To Be Published
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8YJZ
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4Q09
 | | Crystal structure of chimeric carbonic anhydrase XII with inhibitor | | Descriptor: | 1,2-ETHANEDIOL, 3-(cyclooctylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, Carbonic anhydrase 2, ... | | Authors: | Smirnov, A, Manakova, E, Grazulis, S. | | Deposit date: | 2014-04-01 | | Release date: | 2015-01-28 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.
J.Med.Chem., 57, 2014
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8XXV
 | | Cryo-EM Structure of the Prostaglandin D2 Receptor 2-indomethacin Coupled to G Protein | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Xu, J, Xu, Y, Wu, C, Xu, H.E. | | Deposit date: | 2024-01-19 | | Release date: | 2024-12-04 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (2.33 Å) | | Cite: | Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2.
Proc.Natl.Acad.Sci.USA, 121, 2024
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4QOH
 | | Crystal structure of fad quinone reductase 2 in complex with resveratrol at 1.6A | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, RESVERATROL, ... | | Authors: | Serriere, J, Boutin, J.A, Isabet, T, Antoine, M, Ferry, G. | | Deposit date: | 2014-06-20 | | Release date: | 2015-07-01 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of fad quinone reductase 2 in complex
with resveratrol at 1.6A
To be Published
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8YJS
 | | Structure of the human endogenous PCNA-FEN1 complex - State E | | Descriptor: | 5 prime flap DNA, Flap endonuclease 1, Proliferating cell nuclear antigen, ... | | Authors: | Tian, Y, Gao, N. | | Deposit date: | 2024-03-02 | | Release date: | 2024-12-04 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Structural insight into Okazaki fragment maturation mediated by PCNA-bound FEN1 and RNaseH2.
Embo J., 44, 2025
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8YJQ
 | | Structure of the human endogenous PCNA-FEN1 complex - State C | | Descriptor: | 5 prime flap DNA, Flap endonuclease 1, Proliferating cell nuclear antigen, ... | | Authors: | Tian, Y, Gao, N. | | Deposit date: | 2024-03-02 | | Release date: | 2024-12-04 | | Last modified: | 2025-01-29 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Structural insight into Okazaki fragment maturation mediated by PCNA-bound FEN1 and RNaseH2.
Embo J., 44, 2025
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4Q1P
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8XWB
 | | Crystal structure of dinitrosyl iron units binding with human heavy chain Ferritin | | Descriptor: | CHLORIDE ION, FE (III) ION, Ferritin heavy chain, ... | | Authors: | Gong, W.J, Wang, W.M, Wang, H.F. | | Deposit date: | 2024-01-16 | | Release date: | 2024-12-11 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Insight into the photodynamic mechanism and protein binding of a nitrosyl iron-sulfur [Fe 2 S 2 (NO) 4 ] 2- cluster.
Spectrochim Acta A Mol Biomol Spectrosc, 320, 2024
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8I00
 | | Crystal structure of A97S transthyretin | | Descriptor: | Transthyretin | | Authors: | Agrawal, S, Yu, T.-Y. | | Deposit date: | 2023-01-10 | | Release date: | 2024-01-17 | | Last modified: | 2025-02-05 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The Structural and Dynamic Insights into the Ala97Ser Amyloidogenic Mutation in Transthyretin.
Chem Asian J, 2024
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4OH2
 | | Crystal Structure of Cu/Zn Superoxide Dismutase I149T | | Descriptor: | COPPER (II) ION, Superoxide dismutase [Cu-Zn], ZINC ION | | Authors: | Crane, B.R, Merz, G.E. | | Deposit date: | 2014-01-16 | | Release date: | 2014-10-15 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (2.384 Å) | | Cite: | Copper-Based Pulsed Dipolar ESR Spectroscopy as a Probe of Protein Conformation Linked to Disease States.
Biophys.J., 107, 2014
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8IHL
 | | Overlapping tri-nucleosome | | Descriptor: | DNA (353-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | Authors: | Nishimura, M, Fujii, T, Tanaka, H, Maehara, K, Nozawa, K, Takizawa, Y, Ohkawa, Y, Kurumizaka, H. | | Deposit date: | 2023-02-23 | | Release date: | 2024-01-17 | | Last modified: | 2024-01-24 | | Method: | ELECTRON MICROSCOPY (7.64 Å) | | Cite: | Genome-wide mapping and cryo-EM structural analyses of the overlapping tri-nucleosome composed of hexasome-hexasome-octasome moieties.
Commun Biol, 7, 2024
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