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2V42
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Crystal structure of RseB: a sensor for periplasmic stress response in E. coli
Descriptor: ETHYL DIMETHYL AMMONIO PROPANE SULFONATE, SIGMA-E FACTOR REGULATORY PROTEIN RSEB
Authors:Wollmann, P, Zeth, K.
Deposit date:2007-06-27
Release date:2007-08-28
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The Structure of Rseb: A Sensor in Periplasmic Stress Response of E. Coli.
J.Mol.Biol., 372, 2007
6CUZ
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BU of 6cuz by Molmil
Engineered TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3R)-ethylserine bound as the amino-acrylate
Descriptor: (2E)-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]pent-2-enoic acid, PHOSPHATE ION, SODIUM ION, ...
Authors:Scheele, R.A, Buller, A.R, Boville, C.E, Arnold, F.H.
Deposit date:2018-03-27
Release date:2018-09-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Engineered Biosynthesis of beta-Alkyl Tryptophan Analogues.
Angew. Chem. Int. Ed. Engl., 57, 2018
6CUT
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BU of 6cut by Molmil
Engineered Holo TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3S)-isopropylserine bound as the external aldimine
Descriptor: (2S,3S)-3-hydroxy-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]-4-methylpentanoic acid (non-preferred name), SODIUM ION, Tryptophan synthase beta chain 1
Authors:Boville, C.E, Scheele, R.A, Buller, A.R, Arnold, F.H.
Deposit date:2018-03-26
Release date:2018-09-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Engineered Biosynthesis of beta-Alkyl Tryptophan Analogues.
Angew. Chem. Int. Ed. Engl., 57, 2018
7HOY
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BU of 7hoy by Molmil
PanDDA analysis group deposition -- Crystal Structure of ZIKV NS2B-NS3 protease in complex with ASAP-0014767-001
Descriptor: 3-chloro-5-[(E)-({3-[(dimethylamino)methyl]-4-hydroxyphenyl}methylidene)amino]-N-(1-hydroxy-2-methylpropan-2-yl)benzamide, DIMETHYL SULFOXIDE, SULFATE ION, ...
Authors:Ni, X, Marples, P.G, Godoy, A.S, Koekemoer, L, Aschenbrenner, J.C, Balcomb, B.H, Fairhead, M, Lithgo, R.M, Lee, A, Kenton, N, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Williams, E.P, Chandran, A.V, Walsh, M.A, Fearon, D, von Delft, F.
Deposit date:2024-11-07
Release date:2025-05-28
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:PanDDA analysis group deposition
To Be Published
8VQ4
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BU of 8vq4 by Molmil
CDK2-CyclinE1 in complex with allosteric inhibitor I-125A.
Descriptor: (8R)-6-(1-benzyl-1H-pyrazole-4-carbonyl)-N-[(2S,3R)-3-(2-cyclohexylethoxy)-1-(methylamino)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-2,6-diazaspiro[3.4]octane-8-carboxamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1
Authors:Hirschi, M, Johnson, E, Zhang, Y, Liu, Z, Brodsky, O, Won, S.J, Nagata, A, Petroski, M.D, Majmudar, J.D, Niessen, S, VanArsdale, T, Gilbert, A.M, Hayward, M.M, Stewart, A.E, Nager, A.R, Melillo, B, Cravatt, B.
Deposit date:2024-01-17
Release date:2024-01-31
Last modified:2025-03-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes.
Nat.Chem.Biol., 21, 2025
8VQ3
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BU of 8vq3 by Molmil
CDK2-CyclinE1 in complex with allosteric inhibitor I-198.
Descriptor: (8R)-N-[(2S,3R)-3-(cyclohexylmethoxy)-1-(morpholin-4-yl)-1-oxobutan-2-yl]-2-[(1S)-2,2-dimethylcyclopropane-1-carbonyl]-6-(1,3-thiazole-5-carbonyl)-2,6-diazaspiro[3.4]octane-8-carboxamide, Cyclin-dependent kinase 2, G1/S-specific cyclin-E1
Authors:Hirschi, M, Johnson, E, Zhang, Y, Liu, Z, Brodsky, O, Won, S.J, Nagata, A, Petroski, M.D, Majmudar, J.D, Niessen, S, VanArsdale, T, Gilbert, A.M, Hayward, M.M, Stewart, A.E, Nager, A.R, Melillo, B, Cravatt, B.
Deposit date:2024-01-17
Release date:2024-01-31
Last modified:2025-03-12
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes.
Nat.Chem.Biol., 21, 2025
7RF9
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BU of 7rf9 by Molmil
O2-, PLP-dependent desaturase Plu4 intermediate-bound enzyme
Descriptor: (2E)-5-carbamimidamido-2-{[(Z)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4(1H)-ylidene}methyl]imino}pentanoic acid, 1,2-ETHANEDIOL, 2-(2-ETHOXYETHOXY)ETHANOL, ...
Authors:Hoffarth, E.R, Ryan, K.S.
Deposit date:2021-07-13
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.926 Å)
Cite:A shared mechanistic pathway for pyridoxal phosphate-dependent arginine oxidases.
Proc.Natl.Acad.Sci.USA, 118, 2021
4O4K
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BU of 4o4k by Molmil
DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities
Descriptor: (5~{E})-2-azanylidene-5-[(4-hydroxyphenyl)methylidene]-1,3-thiazolidin-4-one, Exonuclease, putative, ...
Authors:Shibata, A, Moiani, D, Arvai, A.S, Perry, J, Harding, S.M, Genois, M, Maity, R, Rossum-Fikkert, S, Kertokalio, A, Romoli, F, Ismail, A, Ismalaj, E, Petricci, E, Neale, M.J, Bristow, R.G, Masson, J, Wyman, C, Jeggo, P.A, Tainer, J.A.
Deposit date:2013-12-18
Release date:2014-01-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.
Mol.Cell, 53, 2014
2WO5
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BU of 2wo5 by Molmil
Structure of wild type E. coli N-acetylneuraminic acid lyase in space group P21 crystal form I
Descriptor: N-ACETYLNEURAMINATE LYASE
Authors:Campeotto, I, Bolt, A.H, Harman, T.A, Trinh, C.H, Dennis, C.A, Phillips, S.E.V, Pearson, A.R, Nelson, A, Berry, A.
Deposit date:2009-07-21
Release date:2010-08-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Insights Into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution.
J.Mol.Biol., 404, 2010
2WNN
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BU of 2wnn by Molmil
Structure of wild type E. coli N-acetylneuraminic acid lyase in complex with pyruvate in space group P21
Descriptor: N-ACETYLNEURAMINATE LYASE, PENTAETHYLENE GLYCOL, SODIUM ION
Authors:Campeotto, I, Bolt, A.H, Harman, T.A, Trinh, C.H, Dennis, C.A, Phillips, S.E.V, Pearson, A.R, Nelson, A, Berry, A.
Deposit date:2009-07-13
Release date:2010-08-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Insights Into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution.
J.Mol.Biol., 404, 2010
6CWD
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BU of 6cwd by Molmil
Hepatitis B core-antigen in complex with scFv e13
Descriptor: Capsid protein, Single chain variable fragment (scFv) e13
Authors:Eren, E, Steven, A.C, Wingfield, P.T.
Deposit date:2018-03-30
Release date:2018-08-29
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.33 Å)
Cite:Structures of Hepatitis B Virus Core- and e-Antigen Immune Complexes Suggest Multi-point Inhibition.
Structure, 26, 2018
6HZU
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BU of 6hzu by Molmil
HUMAN JAK1 IN COMPLEX WITH LASW1393
Descriptor: 2-[4-[8-oxidanylidene-2-[(~{E})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{H}-purin-9-yl]cyclohexyl]ethanenitrile, Tyrosine-protein kinase JAK1
Authors:Lozoya, E, Segarra, V, Bach, J, Jestel, A, Lammens, A, Blaesse, M.
Deposit date:2018-10-24
Release date:2019-10-23
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases.
J.Med.Chem., 62, 2019
8VTU
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BU of 8vtu by Molmil
Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution
Descriptor: 1-cyclopropyl-7-[(4-{[3-({(3aR,4R,7R,8S,9S,10R,11R,13R,14E,15S,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-4-ethyl-11-methoxy-3a,7,9,11,13,15-hexamethyl-14-[({3-[5-(methylcarbamoyl)pyridin-3-yl]prop-2-yn-1-yl}oxy)imino]-2,6-dioxododecahydro-2H,4H-[1,3]dioxolo[4,5-c]oxacyclotetradecin-8-yl}oxy)-3-oxopropyl]amino}butyl)amino]-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Aleksandrova, E.V, Ma, C.-X, Klepacki, D, Alizadeh, F, Vazquez-Laslop, N, Liang, J.-H, Polikanov, Y.S, Mankin, A.S.
Deposit date:2024-01-27
Release date:2024-08-07
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Nat.Chem.Biol., 20, 2024
8VTV
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BU of 8vtv by Molmil
Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution
Descriptor: 1-cyclopropyl-7-{7-[({[(3aR,4R,7R,8S,9S,10R,11R,13R,14E,15S,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-4-ethyl-11-methoxy-14-(methoxyimino)-3a,7,9,11,13,15-hexamethyl-2,6-dioxododecahydro-2H,4H-[1,3]dioxolo[4,5-c]oxacyclotetradecin-8-yl]oxy}carbonyl)amino]hept-1-yn-1-yl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Aleksandrova, E.V, Ma, C.-X, Klepacki, D, Alizadeh, F, Vazquez-Laslop, N, Liang, J.-H, Polikanov, Y.S, Mankin, A.S.
Deposit date:2024-01-27
Release date:2024-08-07
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Nat.Chem.Biol., 20, 2024
8VTX
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BU of 8vtx by Molmil
Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution
Descriptor: 1-cyclopropyl-7-(4-{4-[({[(3aR,4R,7R,8S,9S,10R,11R,13R,14E,15S,15aR)-10-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-4-ethyl-11-methoxy-14-(methoxyimino)-3a,7,9,11,13,15-hexamethyl-2,6-dioxododecahydro-2H,4H-[1,3]dioxolo[4,5-c]oxacyclotetradecin-8-yl]oxy}carbonyl)amino]butyl}piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (non-preferred name), 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Aleksandrova, E.V, Ma, C.-X, Klepacki, D, Alizadeh, F, Vazquez-Laslop, N, Liang, J.-H, Polikanov, Y.S, Mankin, A.S.
Deposit date:2024-01-27
Release date:2024-08-07
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.
Nat.Chem.Biol., 20, 2024
8WHL
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BU of 8whl by Molmil
Crystal structure of CLASP2 in complex with CENP-E
Descriptor: ACETATE ION, CLIP-associating protein 2, Centromere-associated protein E, ...
Authors:Jia, X, Wei, Z.
Deposit date:2023-09-23
Release date:2024-08-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:CLASP-mediated competitive binding in protein condensates directs microtubule growth.
Nat Commun, 15, 2024
6XJA
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BU of 6xja by Molmil
Streptococcus Pneumoniae IgA1 Protease with IgA1 substrate
Descriptor: Immunoglobulin A1 protease, Immunoglobulin alpha-1 heavy chain, Immunoglobulin alpha-1 light chain, ...
Authors:Eisenmesser, E.Z, Zheng, H.
Deposit date:2020-06-23
Release date:2021-01-20
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease.
Nat Commun, 11, 2020
7WTM
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BU of 7wtm by Molmil
Cryo-EM structure of a yeast pre-40S ribosomal subunit - State Dis-E
Descriptor: 18S rRNA, 40S ribosomal protein S1-A, 40S ribosomal protein S11-A, ...
Authors:Cheng, J, La Venuta, G, Lau, B, Berninghausen, O, Beckmann, R, Hurt, E.
Deposit date:2022-02-05
Release date:2022-10-19
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:In vitro structural maturation of an early stage pre-40S particle coupled with U3 snoRNA release and central pseudoknot formation.
Nucleic Acids Res., 50, 2022
6H58
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BU of 6h58 by Molmil
Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - Full 100S Hibernating E. coli Ribosome
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ...
Authors:Beckert, B, Turk, M, Czech, A, Berninghausen, O, Beckmann, R, Ignatova, Z, Plitzko, J, Wilson, D.N.
Deposit date:2018-07-24
Release date:2018-09-05
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (7.9 Å)
Cite:Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1.
Nat Microbiol, 3, 2018
8VXL
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BU of 8vxl by Molmil
Crystal Structure of the External Aldimine Complex of Pyridoxal-5'-Tetrazole and (S)-4-amino-5-phenoxypentanoate with the Bacillus subtilis GabR C-terminal Effector-binding and Oligomerization Domain
Descriptor: (4S)-4-[(E)-({3-hydroxy-2-methyl-5-[(E)-2-(1H-tetrazol-5-yl)ethenyl]pyridin-4-yl}methylidene)amino]-5-phenoxypentanoic acid, GLYCEROL, HTH-type transcriptional regulatory protein GabR, ...
Authors:Kaley, N.E, Liveris, Z.J, Becker, D.P, Liu, D.
Deposit date:2024-02-05
Release date:2025-01-08
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Bioisosteric replacement of pyridoxal-5'-phosphate to pyridoxal-5'-tetrazole targeting Bacillus subtilis GabR.
Protein Sci., 34, 2025
7N6K
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BU of 7n6k by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RALALLPLSR
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N6J
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BU of 7n6j by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RKQSTIALALLPLLFTPRR
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N6L
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BU of 7n6l by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide EANQQKPLLGLFADG
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, GLYCEROL, ...
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
2WPB
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BU of 2wpb by Molmil
Crystal structure of the E192N mutant of E. Coli N-acetylneuraminic acid lyase in complex with pyruvate and the inhibitor (2R,3R)-2,3,4- trihydroxy-N,N-dipropylbutanamide in space group P21 crystal form I
Descriptor: (2R,3R)-2,3,4-TRIHYDROXY-N,N-DIPROPYLBUTANAMIDE, N-ACETYLNEURAMINATE LYASE
Authors:Campeotto, I, Bolt, A.H, Harman, T.A, Trinh, C.H, Dennis, C.A, Phillips, S.E.V, Pearson, A.R, Nelson, A, Berry, A.
Deposit date:2009-08-03
Release date:2010-08-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Insights Into Substrate Specificity in Variants of N-Acetylneuraminic Acid Lyase Produced by Directed Evolution.
J.Mol.Biol., 404, 2010
6O3H
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BU of 6o3h by Molmil
Icosahedral reconstruction of the thermophilic bacteriophage P74-26 capsid
Descriptor: Major head protein, P74-26 Head Decoration Protein
Authors:Stone, N.P, Demo, G, Agnello, E, Kelch, B.A.
Deposit date:2019-02-26
Release date:2019-07-24
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Principles for enhancing virus capsid capacity and stability from a thermophilic virus capsid structure.
Nat Commun, 10, 2019

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