PDB: 7770 resultsInfo pagesStatus searchChemie searchBIRD

---

4LVT	Bcl_2-Navitoclax (ABT-263) Complex Descriptor: 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide, Apoptosis regulator Bcl-2 Authors: Park, C.H. Deposit date: 2013-07-26 Release date: 2013-08-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.05 Å) Cite: ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. NAT.MED. (N.Y.), 19, 2013
4W9A	Crystal structure of Gamma-B Crystallin expressed in E. coli based on mRNA variant 2 Descriptor: Gamma-crystallin B Authors: Kudlinzki, D, Buhr, F, Linhard, V.L, Jha, S, Komar, A.A, Schwalbe, H. Deposit date: 2014-08-27 Release date: 2015-09-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.38 Å) Cite: Two synonymous gene variants encode proteins with identical sequence, but different folding conformations. To Be Published
2J8J	Solution Structure of the A4 Domain of Blood Coagulation Factor XI Descriptor: COAGULATION FACTOR XI Authors: Samuel, D, Cheng, H, Riley, P.W, Canutescu, A.A, Bu, Z, Walsh, P.N, Roder, H. Deposit date: 2006-10-25 Release date: 2007-10-02 Last modified: 2011-07-13 Method: SOLUTION NMR Cite: Solution Structure of the A4 Domain of Factor Xi Sheds Light on the Mechanism of Zymogen Activation. Proc.Natl.Acad.Sci.USA, 104, 2007
2J8L	FXI Apple 4 domain loop-out conformation Descriptor: COAGULATION FACTOR XI Authors: Samuel, D, Cheng, H, Riley, P.W, Canutescu, A.A, Bu, Z, Walsh, P.N, Roder, H. Deposit date: 2006-10-25 Release date: 2007-10-02 Last modified: 2011-07-13 Method: SOLUTION NMR Cite: Solution Structure of the A4 Domain of Factor Xi Sheds Light on the Mechanism of Zymogen Activation. Proc.Natl.Acad.Sci.USA, 104, 2007
4WD4	Crystal structure of human HO1 H25R Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE Authors: Caaveiro, J.M.M, Morante, K, Sigala, P, Tsumoto, K. Deposit date: 2014-09-06 Release date: 2015-09-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.95 Å) Cite: In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis Biochemistry, 55, 2016
4LXD	Bcl_2-Navitoclax Analog (without Thiophenyl) Complex Descriptor: 4-(4-{[4-(4-chlorophenyl)-5,6-dihydro-2H-pyran-3-yl]methyl}piperazin-1-yl)-N-{[3-nitro-4-(tetrahydro-2H-pyran-4-ylamino)phenyl]sulfonyl}benzamide, Apoptosis regulator Bcl-2 Authors: Park, C.H. Deposit date: 2013-07-29 Release date: 2013-08-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. NAT.MED. (N.Y.), 19, 2013
4MAN	Bcl_2-Navitoclax Analog (with Indole) Complex Descriptor: 4-[4-({4'-chloro-3-[2-(dimethylamino)ethoxy]biphenyl-2-yl}methyl)piperazin-1-yl]-2-(1H-indol-5-yloxy)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)benzamide, Apoptosis regulator Bcl-2 Authors: Park, C.H. Deposit date: 2013-08-16 Release date: 2014-01-29 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.07 Å) Cite: ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. NAT.MED. (N.Y.), 19, 2013
1SSX	0.83A resolution crystal structure of alpha-lytic protease at pH 8 Descriptor: Alpha-lytic protease, GLYCEROL, SULFATE ION Authors: Fuhrmann, C.N, Agard, D.A. Deposit date: 2004-03-24 Release date: 2004-05-04 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (0.83 Å) Cite: The 0.83A Resolution Crystal Structure of alpha-Lytic Protease Reveals the Detailed Structure of the Active Site and Identifies a Source of Conformational Strain. J.Mol.Biol., 338, 2004
1ZJK	Crystal structure of the zymogen catalytic region of human MASP-2 Descriptor: Mannan-binding lectin serine protease 2 Authors: Gal, P, Harmat, V, Kocsis, A, Bian, T, Barna, L, Ambrus, G, Vegh, B, Balczer, J, Sim, R.B, Naray-Szabo, G, Zavodszky, P. Deposit date: 2005-04-29 Release date: 2005-07-26 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.18 Å) Cite: A True Autoactivating Enzyme: Structural insight into mannose-binding lectin-associated serine protease-2 activations J.Biol.Chem., 280, 2005
8TDO	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient-3, variant-type morphology Descriptor: Transthyretin Authors: Nguyen, B.A, Singh, V, Saelices, L. Deposit date: 2023-07-04 Release date: 2023-12-13 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024
8TDN	Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient-3, wild-type morphology Descriptor: Transthyretin Authors: Nguyen, B.A, Singh, V, Saelices, L. Deposit date: 2023-07-04 Release date: 2023-12-13 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun, 15, 2024
7D49	X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5 Descriptor: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Wan, Q, Dealwis, C. Deposit date: 2020-09-23 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.651 Å) Cite: Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis Acs Catalysis, 11, 2021
7D3Z	X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5 Descriptor: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Wan, Q, Dealwis, C. Deposit date: 2020-09-21 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis Acs Catalysis, 11, 2021
7D4L	X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH7.0 Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Wan, Q, Dealwis, C. Deposit date: 2020-09-24 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis Acs Catalysis, 11, 2021
7D4X	X-ray crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH7.0 Descriptor: Dihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Wan, Q, Dealwis, C. Deposit date: 2020-09-24 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.599 Å) Cite: Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis Acs Catalysis, 11, 2021
7D6G	Neutron crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5 Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION, ... Authors: Wan, Q, Dealwis, C. Deposit date: 2020-09-30 Release date: 2021-06-09 Last modified: 2024-04-03 Method: NEUTRON DIFFRACTION (1.65 Å), X-RAY DIFFRACTION Cite: Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis Acs Catalysis, 11, 2021
7D2K	Crystal structure of rat TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor Br-cis-22a Descriptor: 1-(5-bromanylpyridin-3-yl)-4-[4-(3-methylphenyl)cyclohexyl]piperazin-4-ium, CALCIUM ION, Transient receptor potential cation channel subfamily V member 6 Authors: Singh, A.K, Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. Deposit date: 2020-09-16 Release date: 2021-10-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.698 Å) Cite: Inactivation-mimicking block of the epithelial calcium channel TRPV6. Sci Adv, 6, 2020
1WVM	Crystal Structure of Psychrophilic Subtilisin-like Serine Protease APA1 from Antarctic Psychrotroph Pseudoaleromonas sp. AS-11, Complexed with Inhibitor Chymostatin Descriptor: CALCIUM ION, CHYMOSTATIN, MAGNESIUM ION, ... Authors: Dong, D, Watanabe, K. Deposit date: 2004-12-16 Release date: 2006-03-21 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structure of Psychrophilic Subtilisin-like Serine Protease from Antarctic Psychrotroph Pseudoalteromonas sp. AS-11 at 0.16 nm resolution To be Published
7F29	Cryo-EM structure of the fibril formed by disaccharide-modified amyloid-beta(1-42) Descriptor: ACETIC ACID, Amyloid-beta A4 protein, beta-D-galactopyranose-(1-3)-2-amino-2-deoxy-alpha-D-galactopyranose Authors: Xia, W.C, Sun, Y.P, Liu, C. Deposit date: 2021-06-10 Release date: 2022-07-13 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: O-Glycosylation Induces Amyloid-beta To Form New Fibril Polymorphs Vulnerable for Degradation J.Am.Chem.Soc., 143, 2021
8SOV	Proteinase K Multiconformer Model at 353K Descriptor: ALA-ALA-ALA-SER-VAL-LYS, CALCIUM ION, Proteinase K, ... Authors: Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. Deposit date: 2023-04-30 Release date: 2023-08-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.291 Å) Cite: Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data. Methods Enzymol., 688, 2023
8SPL	Proteinase K Multiconformer Model at 343K Descriptor: ALA-ALA-ALA-SER-VAL-LYS, CALCIUM ION, Proteinase K, ... Authors: Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. Deposit date: 2023-05-03 Release date: 2023-08-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.21 Å) Cite: Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data. Methods Enzymol., 688, 2023
8SOU	Proteinase K Multiconformer Model at 363K Descriptor: ALA-ALA-ALA-SER-VAL-LYS, CALCIUM ION, Proteinase K, ... Authors: Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. Deposit date: 2023-04-30 Release date: 2023-08-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data. Methods Enzymol., 688, 2023
8SQV	Proteinase K Multiconformer Model at 333K Descriptor: CALCIUM ION, Proteinase K, SULFATE ION Authors: Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. Deposit date: 2023-05-04 Release date: 2023-08-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.22 Å) Cite: Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data. Methods Enzymol., 688, 2023
8SOG	Proteinase K Multiconformer Model at 313K Descriptor: CALCIUM ION, Proteinase K, SULFATE ION Authors: Du, S, Wankowicz, S, Yabukarski, F, Doukov, T, Herschlag, D, Fraser, J.S. Deposit date: 2023-04-28 Release date: 2023-08-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.13 Å) Cite: Refinement of multiconformer ensemble models from multi-temperature X-ray diffraction data. Methods Enzymol., 688, 2023
5I4R	Contact-dependent inhibition system from Escherichia coli NC101 - ternary CdiA/CdiI/EF-Tu complex (trypsin-modified) Descriptor: Contact-dependent inhibitor A, Contact-dependent inhibitor I, Elongation factor Tu, ... Authors: Michalska, K, Stols, L, Eschenfeldt, W, Hayes, C.S, Goulding, C.W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structure-Function Analysis of Polymorphic CDI Toxin-Immunity Protein Complexes (UC4CDI) Deposit date: 2016-02-12 Release date: 2017-06-28 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structure of a novel antibacterial toxin that exploits elongation factor Tu to cleave specific transfer RNAs. Nucleic Acids Res., 45, 2017

<43444546474849505152535455565758>