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1GQ4	STRUCTURAL DETERMINANTS OF THE NHERF INTERACTION WITH BETA2AR AND PDGFR Descriptor: CHLORIDE ION, EZRIN-RADIXIN-MOESIN BINDING PHOSPHOPROTEIN-50 Authors: Karthikeyan, S, Leung, T, Ladias, J.A.A. Deposit date: 2001-11-19 Release date: 2002-05-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Determinants of the Na+/H+ Exchanger Regulatory Factor Interaction with the Beta 2 Adrenergic and Platelet-Derived Growth Factor Receptors J.Biol.Chem., 277, 2002
8CQY	Crystal structure of the PTPN3 PDZ domain bound to the PBM TACE C-terminal peptide Descriptor: Disintegrin and metalloproteinase domain-containing protein 17, SODIUM ION, Tyrosine-protein phosphatase non-receptor type 3 Authors: Genera, M, Colcombet-Cazenave, B, Croitoru, A, Raynal, B, Mechaly, A, Caillet, J, Haouz, A, Wolff, N, Caillet-Saguy, C. Deposit date: 2023-03-07 Release date: 2023-05-10 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity. Front Mol Biosci, 10, 2023
1GQ5	Structural Determinants of the NHERF Interaction with beta2-AR and PDGFR Descriptor: CHLORIDE ION, EZRIN-RADIXIN-MOESIN BINDING PHOSPHOPROTEIN-50 Authors: Karthikeyan, S, Leung, T, Ladias, J.A.A. Deposit date: 2001-11-20 Release date: 2002-11-14 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Determinants of the Na+/H+ Exchanger Regulatory Factor Interaction with the Beta 2 Adrenergic and Platelet-Derived Growth Factor Receptors J.Biol.Chem., 277, 2002
8C1T	Crystal structure of Trichoplax Dlg PDZ1 domain in complex with Trichoplax Vangl peptide Descriptor: Disks large-like protein 1, MALONIC ACID, Vang-like protein 1 Authors: Maddumage, J.C, Kvansakul, M. Deposit date: 2022-12-21 Release date: 2024-01-10 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of Trichoplax Dlg PDZ1 domain in complex with Trichoplax Vangl peptide To be published
8CD3	Crystal structure of human Scribble PDZ1 domain in complex with human TMIGD1 Descriptor: Protein scribble homolog, Transmembrane and immunoglobulin domain-containing protein 1 Authors: Maddumage, J.C, Kvansakul, M. Deposit date: 2023-01-30 Release date: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Membrane recruitment of the polarity protein Scribble by the cell adhesion receptor TMIGD1. Commun Biol, 6, 2023
1I16	STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES Descriptor: INTERLEUKIN 16 Authors: Muehlhahn, P, Zweckstetter, M, Georgescu, J, Ciosto, C, Renner, C, Lanzendoerfer, M, Lang, K, Ambrosius, D, Baier, M, Kurth, R, Holak, T.A. Deposit date: 1998-05-20 Release date: 1999-05-25 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Structure of interleukin 16 resembles a PDZ domain with an occluded peptide binding site. Nat.Struct.Biol., 5, 1998
1IU0	The first PDZ domain of PSD-95 Descriptor: PSD-95 Authors: Long, J.-F, Tochio, H, Wang, P, Sala, C, Niethammer, M, Sheng, M, Zhang, M. Deposit date: 2002-02-18 Release date: 2003-03-11 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95 J.MOL.BIOL., 327, 2003
1IU2	The first PDZ domain of PSD-95 Descriptor: PSD-95 Authors: Long, J.-F, Tochio, H, Wang, P, Sala, C, Niethammer, M, Sheng, M, Zhang, M. Deposit date: 2002-02-19 Release date: 2003-03-11 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95 J.MOL.BIOL., 327, 2003
1IHJ	Crystal Structure of the N-terminal PDZ domain of InaD in complex with a NorpA C-terminal peptide Descriptor: InaD, phospholipase C Authors: Kimple, M.E, Siderovski, D.P, Sondek, J. Deposit date: 2001-04-19 Release date: 2001-08-22 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA. EMBO J., 20, 2001
1GM1	Second PDZ Domain (PDZ2) of PTP-BL Descriptor: PROTEIN TYROSINE PHOSPHATASE Authors: Walma, T, Tessari, M, Aelen, J, Schepens, J, Hendriks, W, Vuister, G.W. Deposit date: 2001-09-06 Release date: 2002-03-08 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL. J. Mol. Biol., 316, 2002
4Q6S	CFTR Associated Ligand (CAL) PDZ bound to biotinylated peptide BT-L-iCAL36 Descriptor: BT-L-iCAL36 peptide, Golgi-associated PDZ and coiled-coil motif-containing protein Authors: Amacher, J.F, Madden, D.R. Deposit date: 2014-04-23 Release date: 2015-04-29 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Modulator Preferences are Critical Co-Determinants of PDZ Network Wiring To be Published
4Q2P	NHERF3 PDZ2 in Complex with a Phage-Derived Peptide Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Na(+)/H(+) exchange regulatory cofactor NHE-RF3 Authors: Appleton, B.A, Wiesmann, C. Deposit date: 2014-04-09 Release date: 2014-09-10 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.05 Å) Cite: A structural portrait of the PDZ domain family. J.Mol.Biol., 426, 2014
4Q3H	The crystal structure of NHERF1 PDZ2 CXCR2 complex revealed by the NHERF1 CXCR2 chimeric protein Descriptor: Na(+)/H(+) exchange regulatory cofactor NHE-RF1 Authors: Holcomb, J, Jiang, Y, Trescott, L, Lu, G, Brunzelle, J, Sirinupong, N, Li, C, Yang, Z. Deposit date: 2014-04-11 Release date: 2014-05-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.443 Å) Cite: Crystal structure of the NHERF1 PDZ2 domain in complex with the chemokine receptor CXCR2 reveals probable modes of PDZ2 dimerization. Biochem.Biophys.Res.Commun., 448, 2014
4Q2N	INADL PDZ3 in Complex with a Phage-Derived Peptide Descriptor: 1,2-ETHANEDIOL, InaD-like protein Authors: Appleton, B.A, Wiesmann, C. Deposit date: 2014-04-09 Release date: 2014-09-10 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: A structural portrait of the PDZ domain family. J.Mol.Biol., 426, 2014
7VZE	Crystal structure of PTPN4 PDZ bound to the PBM of HPV16 E6 Descriptor: Tyrosine-protein phosphatase non-receptor type 4, the PDZ-binding motif of HPV16 E6 Authors: Lee, H.S, Yun, H.-Y, Ku, B. Deposit date: 2021-11-16 Release date: 2022-03-02 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.882 Å) Cite: Structural and biochemical analysis of the PTPN4 PDZ domain bound to the C-terminal tail of the human papillomavirus E6 oncoprotein. J.Microbiol, 60, 2022
7W71	Crystal structure of the PDZ-C domain of E. coli RseP in complex with 12C7 Fab Descriptor: Heavy chain of Fab, Light chain of Fab, Regulator of sigma-E protease RseP Authors: Hirose, T, Katagiri, S, Nogi, T. Deposit date: 2021-12-02 Release date: 2022-09-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP. Sci Adv, 8, 2022
7WEG	Complex structure of PDZD7 and FCHSD2 Descriptor: FCHSD2, PDZ domain-containing protein 7, ZINC ION Authors: Wang, H, Lin, L, Lu, Q. Deposit date: 2021-12-23 Release date: 2022-11-16 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2 Å) Cite: Deafness-related protein PDZD7 forms complex with the C-terminal tail of FCHSD2. Biochem.J., 479, 2022
7X2E	Structure of USH1C PDZ2 and coiled-coil in complex with CDHR2 C-terminal tail Descriptor: Cadherin-related family member 2, GLYCEROL, Harmonin Authors: Yan, W, Chen, G, Li, J. Deposit date: 2022-02-25 Release date: 2022-07-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structure of the Harmonin PDZ2 and coiled-coil domains in a complex with CDHR2 tail and its implications. Faseb J., 36, 2022
4R2Z	Molecular Analysis of the PDZ4 Domain of Mouse PDZK1 Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, GLYCEROL, Na(+)/H(+) exchange regulatory cofactor NHE-RF3 Authors: Birrane, G, Kocher, O, Krieger, M. Deposit date: 2014-08-13 Release date: 2015-08-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Molecular Analysis of the PDZ4 domain from Mouse PDZK1 To be Published
7XTY	Crystal Structure of the second PDZ domain from human PTPN13 in complex with APC peptide Descriptor: APC-peptide, Tyrosine-protein phosphatase non-receptor type 13 Authors: Jing, L.Q, Sun, X.N, Ma, W.H, Zhou, W.J, Wu, D.L. Deposit date: 2022-05-18 Release date: 2023-05-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Targeting PTPN13 with 11 amino acid peptides of C-terminal APC prevents immune evasion of colorectal cancer to be published
3KZD	Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Descriptor: T-lymphoma invasion and metastasis-inducing protein 1 Authors: Shepherd, T.R, Fuentes, E.J. Deposit date: 2009-12-08 Release date: 2010-04-21 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.3 Å) Cite: The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. J.Mol.Biol., 398, 2010
3KZE	Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in Complex With SSRKEYYA Peptide Descriptor: Synthetic Peptide, T-lymphoma invasion and metastasis-inducing protein 1 Authors: Shepherd, T.R, Fuentes, E.J. Deposit date: 2009-12-08 Release date: 2010-04-21 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.8 Å) Cite: The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. J.Mol.Biol., 398, 2010
3LNX	Second PDZ domain from human PTP1E Descriptor: IODIDE ION, THIOCYANATE ION, Tyrosine-protein phosphatase non-receptor type 13 Authors: Zhang, J, Chang, A, Ke, H, Phillips Jr, G.N, Lee, A.L, Center for Eukaryotic Structural Genomics (CESG) Deposit date: 2010-02-03 Release date: 2010-02-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.642 Å) Cite: Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry, 49, 2010
6LCB	Crystal structure of human Dishevelled1 PDZ domain with its inhibitor NPL3009 Descriptor: 2-[[3-[(2E)-2-[1,3-bis(oxidanylidene)-1-phenyl-butan-2-ylidene]hydrazinyl]phenyl]sulfonylamino]benzoic acid, SULFATE ION, Segment polarity protein dishevelled homolog DVL-1 Authors: Yasukochi, S, Numoto, N, Tenno, N, Tenno, T, Ito, N, Hiroaki, H. Deposit date: 2019-11-18 Release date: 2020-11-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Crystal structure of human Dishevelled1 PDZ domain with its inhibitor NPL3009 To Be Published
3LNY	Second PDZ domain from human PTP1E in complex with RA-GEF2 peptide Descriptor: Rap guanine nucleotide exchange factor 6, SULFATE ION, THIOCYANATE ION, ... Authors: Zhang, J, Chang, A, Ke, H, Phillips Jr, G.N, Lee, A.L, Center for Eukaryotic Structural Genomics (CESG) Deposit date: 2010-02-03 Release date: 2010-03-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E. Biochemistry, 49, 2010

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