8CQY

Crystal structure of the PTPN3 PDZ domain bound to the PBM TACE C-terminal peptide

Summary for 8CQY

Entry DOI	10.2210/pdb8cqy/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 3, Disintegrin and metalloproteinase domain-containing protein 17, SODIUM ION, ... (4 entities in total)
Functional Keywords	protein tyrosine phosphatase ptpn3, pdz domains, pdz-binding motif, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	14222.81
Authors	Genera, M.,Colcombet-Cazenave, B.,Croitoru, A.,Raynal, B.,Mechaly, A.,Caillet, J.,Haouz, A.,Wolff, N.,Caillet-Saguy, C. (deposition date: 2023-03-07, release date: 2023-05-10, Last modification date: 2023-05-31)
Primary citation	Genera, M.,Colcombet-Cazenave, B.,Croitoru, A.,Raynal, B.,Mechaly, A.,Caillet, J.,Haouz, A.,Wolff, N.,Caillet-Saguy, C. Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity. Front Mol Biosci, 10:1192621-1192621, 2023 Cited by PubMed: 37200868 DOI: 10.3389/fmolb.2023.1192621 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation