PDB: 980 resultsInfo pagesStatus searchChemie searchBIRD

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8J02	Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II Descriptor: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... Authors: Ma, D, Li, X, Guo, J. Deposit date: 2023-04-09 Release date: 2023-12-13 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
8WE8	Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine, amlodipine and pinaverium at 2.9 Angstrom resolution Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gao, S, Yao, X, Yan, N. Deposit date: 2023-09-17 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
8WE7	Human L-type voltage-gated calcium channel Cav1.2 in the presence of calciseptine at 3.2 Angstrom resolution Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gao, S, Yao, X, Yan, N. Deposit date: 2023-09-17 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
8WE6	Human L-type voltage-gated calcium channel Cav1.2 at 2.9 Angstrom resolution Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gao, S, Yao, X, Yan, N. Deposit date: 2023-09-17 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
8WE9	Human L-type voltage-gated calcium channel Cav1.2 (Class I) in the presence of pinaverium at 3.0 Angstrom resolution Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gao, S, Yao, X, Fan, X, Yan, N. Deposit date: 2023-09-17 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
8WEA	Human L-type voltage-gated calcium channel Cav1.2 (Class II) in the presence of pinaverium at 3.2 Angstrom resolution Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Gao, S, Yao, X, Fan, X, Yan, N. Deposit date: 2023-09-17 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural basis for human Ca v 1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell, 186, 2023
8J05	Human KCNQ2-CaM complex in the presence of PIP2 Descriptor: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2 Authors: Ma, D, Li, X, Guo, J. Deposit date: 2023-04-09 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
8J03	Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state I Descriptor: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, cannabidiol Authors: Ma, D, Li, D, Guo, J. Deposit date: 2023-04-09 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
8J04	Human KCNQ2-CaM-HN37 complex in the presence of PIP2 Descriptor: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate Authors: Ma, D, Li, X, Guo, J. Deposit date: 2023-04-09 Release date: 2023-12-06 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
7YG5	Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the topiramate-bound state Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Gao, Y, Zhao, Y. Deposit date: 2022-07-11 Release date: 2023-11-29 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural insights into allosteric effects of antiepileptic drug topiramate on CaV2.3 channel. To Be Published
8J00	Human KCNQ2-CaM in complex with CBD Descriptor: Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, cannabidiol Authors: Ma, D, Li, X, Guo, J. Deposit date: 2023-04-09 Release date: 2023-11-29 Method: ELECTRON MICROSCOPY (3 Å) Cite: Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
8IZY	Human KCNQ2-CaM in complex with HN37 Descriptor: Potassium voltage-gated channel subfamily KQT member 2, methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate Authors: Ma, D, Li, X, Guo, J. Deposit date: 2023-04-09 Release date: 2023-11-29 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
7XSU	Cardiac sodium channel in complex with LqhIII Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-like toxin Lqh3, ... Authors: Jiang, D, Catterall, W.A. Deposit date: 2022-05-15 Release date: 2023-11-29 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural Basis for Nav1.5 Opening Modulated by a Gating Modifier Toxin To Be Published
8THH	Cryo-EM structure of Nav1.7 with LTG Descriptor: (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... Authors: Fan, X, Huang, J, Yan, N. Deposit date: 2023-07-16 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
8THG	Cryo-EM structure of Nav1.7 with RLZ Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Fan, X, Huang, J, Yan, N. Deposit date: 2023-07-16 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
8UXG	Structure of PKA phosphorylated human RyR2-R420W in the closed state in the presence of ARM210 Descriptor: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.08 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXE	Structure of PKA phosphorylated human RyR2-R420Q in the closed state in the presence of ARM210 Descriptor: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.53 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXI	Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.29 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXF	Structure of PKA phosphorylated human RyR2-R420W in the primed state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXC	Structure of PKA phosphorylated human RyR2-R420Q in the primed state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (2.86 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXH	Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.52 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXM	Structure of PKA phosphorylated human RyR2-R420W in the open state in the presence of calcium and calmodulin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UXL	Structure of PKA phosphorylated human RyR2-R420W in the primed state in the presence of calcium and calmodulin Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-11-09 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UQ3	Structure of human RyR2-S2808D in the closed state in the presence of ARM210 Descriptor: 4-[(7-methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)methyl]benzoic acid, ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-10-23 Release date: 2023-11-15 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
8UQ2	Structure of human RyR2-S2808D in the subprimed state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... Authors: Miotto, M.C, Marks, A.R. Deposit date: 2023-10-23 Release date: 2023-11-15 Method: ELECTRON MICROSCOPY (2.98 Å) Cite: Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published

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