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4XIK	Crystal structure of NanB sialidase from streptococcus pneumoniae in complex with DMSO Descriptor: DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2015-01-07 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.91 Å) Cite: `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4XIO	Crystal structure of apo NanB sialidase from streptococcus pneumoniae at pH 8.0 with MPD as the cryoprotectant Descriptor: Sialidase B Authors: Brear, P. Deposit date: 2015-01-07 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4XJU	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 4-acetamido-2-fluoro-3-hydroxy-6-[1,2-dihydroxyethyl]-7,8-dioxabicyclo[3.2.1]octane-1-carboxylic acid Descriptor: (1R,2R,3R,4R,5R,7R)-2-(acetylamino)-7-[(1R)-1,2-dihydroxyethyl]-4-fluoro-3-hydroxy-6,8-dioxabicyclo[3.2.1]octane-5-carboxylic acid, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... Authors: Brear, P. Deposit date: 2015-01-09 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.94 Å) Cite: `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4XJA	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 5-acetamido-2,3-difluoro-3-hydroxy-6-[1,2,3-trihydroxypropyl]oxane-2-carboxylic acid Descriptor: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, (2R,3R,4R,5R,6R)-5-acetamido-2,3-difluoro-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylic acid, DIMETHYL SULFOXIDE, ... Authors: Brear, P. Deposit date: 2015-01-08 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.98 Å) Cite: `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4XIL	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with Optactin at pH 7.4 in PBS with MPD as the cryoprotectant Descriptor: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, Sialidase B Authors: Brear, P. Deposit date: 2015-01-07 Release date: 2016-01-20 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.9 Å) Cite: `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4XMA	Crystal structure of the K499G mutant of NanB sialidase from streptococcus pneumoniae in complex with Optactin Descriptor: (1s,3R,4S)-1-[(cyclohexylamino)methyl]-3,4-dihydroxycyclopentanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2015-01-14 Release date: 2016-02-03 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.09 Å) Cite: `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
4NTZ	Crystal structure of Adenylate kinase from Streptococcus pneumoniae Descriptor: Adenylate kinase, SULFATE ION Authors: Thach, T.T, Luong, T.T, Lee, S.H, Rhee, D.K. Deposit date: 2013-12-03 Release date: 2014-07-23 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.69 Å) Cite: Adenylate kinase from Streptococcus pneumoniae is essential for growth through its catalytic activity FEBS Open Bio, 4, 2014
4XYX	NanB plus Optactamide Descriptor: Optactamide, PHOSPHATE ION, Sialidase B Authors: Rogers, G.W, Brear, P, Yang, L, Taylor, G.L, Westwood, N.J. Deposit date: 2015-02-03 Release date: 2016-02-10 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To Be Published
4XMI	Crystal structure of the K499G mutant of NanB sialidase from Streptococcus pneumoniae Descriptor: DIMETHYL SULFOXIDE, PHOSPHATE ION, Sialidase B Authors: Brear, P. Deposit date: 2015-01-14 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.97 Å) Cite: The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB To be published
6ITE	Crystal structure of group A Streptococcal surface dehydrogenase (SDH) Descriptor: Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION Authors: Yuan, C, Li, R, Huang, M.D. Deposit date: 2018-11-21 Release date: 2019-09-25 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.739 Å) Cite: Structural determination of group A Streptococcal surface dehydrogenase and characterization of its interaction with urokinase-type plasminogen activator receptor. Biochem.Biophys.Res.Commun., 510, 2019
4FP2	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2[(Cyclohexylmethyl)ammonio]sulfonate Descriptor: 2-[(cyclohexylmethyl)amino]ethanesulfonic acid, Sialidase B Authors: Brear, P. Deposit date: 2012-06-21 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13, 2012
4FPL	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3,4-dichlorobenzyl)ammonio]ethanesulfonate Descriptor: 2-[(3,4-dichlorobenzyl)amino]ethanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2012-06-22 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13, 2012
4FE2	X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+ Descriptor: 5-AMINOIMIDAZOLE RIBONUCLEOTIDE, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... Authors: Wolf, N, Abad-Zapatero, C, Johnson, M.E, Fung, L.M.-W. Deposit date: 2012-05-29 Release date: 2013-05-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.288 Å) Cite: Structures of SAICAR synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg(2+), AIR and Asp. Acta Crystallogr.,Sect.D, 70, 2014
4FPE	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(4-Methoxybenzyl)ammonio]ethanesulfonate Descriptor: 2-[(4-methoxybenzyl)amino]ethanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2012-06-22 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.181 Å) Cite: Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13, 2012
4FPG	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Hydroxybenzyl)ammonio]ethanesulfonate Descriptor: 2-[(3-hydroxybenzyl)amino]ethanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2012-06-22 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.576 Å) Cite: Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13, 2012
4OO8	Crystal structure of Streptococcus pyogenes Cas9 in complex with guide RNA and target DNA Descriptor: CRISPR-associated endonuclease Cas9/Csn1, DNA (5'-D(*CP*CP*AP*GP*CP*CP*AP*AP*GP*CP*GP*CP*AP*CP*CP*TP*AP*AP*TP*TP*TP*CP*C)-3'), RNA (97-MER) Authors: Nishimasu, H, Ishitani, R, Nureki, O. Deposit date: 2014-01-31 Release date: 2014-02-26 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of Cas9 in complex with guide RNA and target DNA Cell(Cambridge,Mass.), 156, 2014
4NU0	Crystal structure of Adenylate kinase from Streptococcus pneumoniae with Ap5A Descriptor: Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, MAGNESIUM ION Authors: Thach, T.T, Luong, T.T, Lee, S.H, Rhee, D.K. Deposit date: 2013-12-03 Release date: 2014-07-23 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.485 Å) Cite: Adenylate kinase from Streptococcus pneumoniae is essential for growth through its catalytic activity FEBS Open Bio, 4, 2014
6HEE	Crystal structure of Extracellular Domain 1 (ECD1) of FtsX from S. pneumonie in complex with undecyl-maltoside Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cell division protein FtsX, SULFATE ION, ... Authors: Martinez-Caballero, S, Alcorlo-Pages, M, Hermoso, J.A. Deposit date: 2018-08-20 Release date: 2019-04-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae. Mbio, 10, 2019
4NYE	Structures of SAICAR Synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg2+, AIR and L-Asp Descriptor: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... Authors: Fung, L.W.-M, Johnson, M.E, Abad-Zapatero, C, Wolf, N.M. Deposit date: 2013-12-10 Release date: 2014-04-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Structures of SAICAR synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg(2+), AIR and Asp. Acta Crystallogr.,Sect.D, 70, 2014
6IFO	Crystal structure of AcrIIA2-SpyCas9-sgRNA ternary complex Descriptor: AcrIIA2, CRISPR-associated endonuclease Cas9/Csn1, RNA (99-MER) Authors: Liu, L, Wang, Y. Deposit date: 2018-09-20 Release date: 2019-01-23 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.313 Å) Cite: Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race. Mol. Cell, 73, 2019
4FOW	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 3-ammoniopropane-1-sulfonate Descriptor: 3-aminopropane-1-sulfonic acid, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2012-06-21 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13, 2012
4FP3	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(Furan-2-ylmethyl)ammonio]sulfonate Descriptor: 2-[(furan-2-ylmethyl)amino]ethanesulfonic acid, Sialidase B Authors: Brear, P. Deposit date: 2012-06-21 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.743 Å) Cite: Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13, 2012
4FPJ	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Methoxybenzyl)ammonio]ethanesulfonate Descriptor: 2-[(3-methoxybenzyl)amino]ethanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2012-06-22 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.981 Å) Cite: Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13, 2012
4FPY	Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 2-[(3-Bromobenzyl)ammonio]ethanesulfonate Descriptor: 2-[(3-bromobenzyl)amino]ethanesulfonic acid, DIMETHYL SULFOXIDE, Sialidase B Authors: Brear, P. Deposit date: 2012-06-23 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases. Chembiochem, 13, 2012
3GLE	Crystal Structure of the Major Pilin from Streptococcus pyogenes N168A mutant Descriptor: Pilin Authors: Kang, H.J, Baker, E.N. Deposit date: 2009-03-12 Release date: 2009-06-02 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Intramolecular isopeptide bonds give thermodynamic and proteolytic stability to the major pilin protein of Streptococcus pyogenes To be Published

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