4XIK

Crystal structure of NanB sialidase from streptococcus pneumoniae in complex with DMSO

Summary for 4XIK

• Entry DOI: 10.2210/pdb4xik/pdb
• Descriptor: Sialidase B, DIMETHYL SULFOXIDE (3 entities in total)
• Functional Keywords: hydrolase, intramolecular trans-sialidase, glycosidase, drug design, neuraminidase, allosteric inhibitor, serendipitous allosteric sites, crystallization artefacts
• Biological source: Streptococcus pneumoniae TIGR4
• Total number of polymer chains: 1
• Total formula weight: 73910.52

Authors

Brear, P. (deposition date: 2015-01-07, release date: 2016-01-20, Last modification date: 2024-01-10)

• Primary citation: Rogers, G.W.,Brear, P.,Yang, L.,Chen, A.S.,Mitchell, J.B.O.,Taylor, G.L.,Westwood, N.J.; `The Hunt for Serendipitous Allosteric Sites: Discovery of a novel allosteric inhibitor of the bacterial sialidase NanB; To be published,

Experimental method

X-RAY DIFFRACTION (1.91 Å)