5V60
 
 | | Phospho-ERK2 bound to AMP-PCP | | Descriptor: | GLYCEROL, MAGNESIUM ION, Mitogen-activated protein kinase 1, ... | | Authors: | Lechtenberg, B.C, Riedl, S.J. | | Deposit date: | 2017-03-15 | | Release date: | 2017-07-26 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.
ACS Med Chem Lett, 8, 2017
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4BKY
 | | Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with pyrrolopyrazole inhibitor | | Descriptor: | 3'-{[(4-bromo-1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-N-[(1S)-1-phenyl-2-(pyrrolidin-1-yl)ethyl]-1',4'-dihydro-5'H-spiro[cyclopropane-1,6'-pyrrolo[3,4-c]pyrazole]-5'-carboxamide, MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, UNKNOWN ATOM OR ION | | Authors: | Canevari, G, Re Depaolini, S, Cucchi, U, Forte, B, Carpinelli, P, Bertrand, J.A. | | Deposit date: | 2013-04-30 | | Release date: | 2013-08-21 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Structural Insight Into Maternal Embryonic Leucine Zipper Kinase (Melk) Conformation and Inhibition Towards Structure- Based Drug Design.
Biochemistry, 52, 2013
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4BL1
 | | Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with AMP-PNP | | Descriptor: | MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Canevari, G, Re-Depaolini, S, Cucchi, U, Forte, B, Carpinelli, P, Bertrand, J.A. | | Deposit date: | 2013-04-30 | | Release date: | 2013-05-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure of Unphosphorylated Maternal Embryonic Leucine Zipper Kinase
To be Published
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4EKK
 | | Akt1 with AMP-PNP | | Descriptor: | Glycogen synthase kinase-3 beta, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Wu, W.-I, Vigers, G.P.A, Morales, T.H, Brandhuber, B.J. | | Deposit date: | 2012-04-09 | | Release date: | 2012-05-23 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt.
Sci.Signal., 5, 2012
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4EG3
 | | Trypanosoma brucei methionyl-tRNA synthetase in complex with product methionyl-adenylate | | Descriptor: | GLYCEROL, Methionyl-tRNA synthetase, putative, ... | | Authors: | Koh, C.Y, Kim, J.E, Shibata, S, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. | | Deposit date: | 2012-03-30 | | Release date: | 2012-09-12 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.
Structure, 20, 2012
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3GLV
 | | Crystal structure of the lipopolysaccharide core biosynthesis protein from Thermoplasma volcanium GSS1 | | Descriptor: | ADENOSINE MONOPHOSPHATE, Lipopolysaccharide core biosynthesis protein, SULFATE ION | | Authors: | Zhang, R, Sather, A, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2009-03-12 | | Release date: | 2009-05-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | The crystal structure of the lipopolysaccharide core biosynthesis protein from Thermoplasma volcanium GSS1
To be Published
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6VT4
 | | Naegleria gruberi RNA ligase R149A mutant apo | | Descriptor: | RNA Ligase | | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | | Deposit date: | 2020-02-12 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Nucleic Acids Res., 48, 2020
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8IAB
 | | The Arabidopsis CLCa transporter bound with chloride, ATP and PIP2 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Chloride channel protein CLC-a, ... | | Authors: | Yang, Z, Zhang, X, Zhang, P. | | Deposit date: | 2023-02-08 | | Release date: | 2023-08-02 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids.
Nat Commun, 14, 2023
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8IAD
 | | The Arabidopsis CLCa transporter bound with nitrate, ATP and PIP2 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Chloride channel protein CLC-a, MAGNESIUM ION, ... | | Authors: | Yang, Z, Zhang, X, Zhang, P. | | Deposit date: | 2023-02-08 | | Release date: | 2023-08-02 | | Last modified: | 2023-08-30 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids.
Nat Commun, 14, 2023
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6VTG
 | | Naegleria gruberi RNA ligase E227A mutant apo | | Descriptor: | RNA ligase | | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | | Deposit date: | 2020-02-12 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Nucleic Acids Res., 48, 2020
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6CBV
 | | Crystal structure of BRIL bound to an affinity matured synthetic antibody. | | Descriptor: | BRIL, FORMIC ACID, GLYCEROL, ... | | Authors: | Mukherjee, S, Skrobek, B, Kossiakoff, A.A. | | Deposit date: | 2018-02-05 | | Release date: | 2019-02-06 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.872 Å) | | Cite: | Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Nat Commun, 11, 2020
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6VT3
 | | Naegleria gruberi RNA ligase K326A mutant apo | | Descriptor: | RNA Ligase | | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | | Deposit date: | 2020-02-12 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.844 Å) | | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Nucleic Acids Res., 48, 2020
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6VT5
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6GDR
 | | DNA binding with a minimal scaffold: Structure-function analysis of Lig E DNA ligases | | Descriptor: | ADENOSINE MONOPHOSPHATE, DNA, DNA (5'-D(*TP*TP*CP*CP*GP*AP*TP*AP*GP*TP*GP*GP*GP*GP*TP*CP*GP*CP*AP*AP*T)-3'), ... | | Authors: | Williamson, A, Grigic, M, Leiros, H.K.S. | | Deposit date: | 2018-04-24 | | Release date: | 2018-07-25 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | DNA binding with a minimal scaffold: structure-function analysis of Lig E DNA ligases.
Nucleic Acids Res., 46, 2018
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6VT0
 | | Naegleria gruberi RNA ligase K170A mutant apo | | Descriptor: | RNA Ligase | | Authors: | Unciuleac, M.C, Goldgur, Y, Shuman, S. | | Deposit date: | 2020-02-12 | | Release date: | 2020-04-08 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.002 Å) | | Cite: | Caveat mutator: alanine substitutions for conserved amino acids in RNA ligase elicit unexpected rearrangements of the active site for lysine adenylylation.
Nucleic Acids Res., 48, 2020
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7TR2
 | | Apo CaKip3[2-436]-L2-mutant(HsKHC) in complex with a microtubule | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein,Kinesin-1 heavy chain, ... | | Authors: | Benoit, M.P.M.H, Asenjo, A.B, Hunter, B, Allingham, J.S, Sosa, H. | | Deposit date: | 2022-01-27 | | Release date: | 2022-07-13 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Kinesin-8-specific loop-2 controls the dual activities of the motor domain according to tubulin protofilament shape.
Nat Commun, 13, 2022
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7UNG
 | | 48-nm repeat of the human respiratory doublet microtubule | | Descriptor: | Cilia- and flagella-associated protein 161, Cilia- and flagella-associated protein 20, Cilia- and flagella-associated protein 45, ... | | Authors: | Gui, M, Croft, J.T, Zabeo, D, Acharya, V, Kollman, J.M, Burgoyne, T, Hoog, J.L, Brown, A. | | Deposit date: | 2022-04-11 | | Release date: | 2022-10-05 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.
Proc.Natl.Acad.Sci.USA, 119, 2022
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3J7Y
 | | Structure of the large ribosomal subunit from human mitochondria | | Descriptor: | 16S rRNA, ADENOSINE MONOPHOSPHATE, CRIF1, ... | | Authors: | Brown, A, Amunts, A, Bai, X.C, Sugimoto, Y, Edwards, P.C, Murshudov, G, Scheres, S.H.W, Ramakrishnan, V. | | Deposit date: | 2014-08-26 | | Release date: | 2014-10-15 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure of the large ribosomal subunit from human mitochondria.
Science, 346, 2014
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6M6U
 | | Crystal structure the toxin-antitoxin MntA-HpeT mutant-D39ED41E | | Descriptor: | Toxin-antitoxin system antitoxin MntA family, Toxin-antitoxin system toxin HepN family | | Authors: | Ouyang, S.Y, Zhen, X.K. | | Deposit date: | 2020-03-16 | | Release date: | 2020-09-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.349 Å) | | Cite: | Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system.
Nucleic Acids Res., 48, 2020
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8HSB
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6III
 | | Crystal structure of an uncharacterized protein | | Descriptor: | ADENOSINE MONOPHOSPHATE, IMIDODIPHOSPHORIC ACID, MAGNESIUM ION, ... | | Authors: | Li, B, Yuan, Z. | | Deposit date: | 2018-10-06 | | Release date: | 2019-10-09 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.113 Å) | | Cite: | Crystal structure of an uncharacterized protein
To Be Published
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6M6W
 | | Crystal structure the toxin-antitoxin MntA-HpeT mutant-Y104A | | Descriptor: | Toxin-antitoxin system antidote Mnt family, Toxin-antitoxin system toxin HepN family | | Authors: | Ouyang, S.Y, Zhen, X.K. | | Deposit date: | 2020-03-16 | | Release date: | 2020-09-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.611 Å) | | Cite: | Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system.
Nucleic Acids Res., 48, 2020
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6M6V
 | | Crystal structure the toxin-antitoxin MntA-HepT | | Descriptor: | RNA (5'-R(P*AP*AP*A)-3'), Toxin-antitoxin system antidote Mnt family, Toxin-antitoxin system toxin HepN family | | Authors: | Ouyang, S.Y, Zhen, X.K. | | Deposit date: | 2020-03-16 | | Release date: | 2020-09-30 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.08 Å) | | Cite: | Novel polyadenylylation-dependent neutralization mechanism of the HEPN/MNT toxin/antitoxin system.
Nucleic Acids Res., 48, 2020
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6P1S
 | | Post-catalytic nicked complex of human DNA Polymerase Mu with 1-nt gapped substrate containing template 8OG and newly incorporated AMP | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Kaminski, A.M, Pedersen, L.C, Bebenek, K, Chiruvella, K.K, Ramsden, D.A, Kunkel, T.A. | | Deposit date: | 2019-05-20 | | Release date: | 2019-09-04 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Unexpected behavior of DNA polymerase Mu opposite template 8-oxo-7,8-dihydro-2'-guanosine.
Nucleic Acids Res., 47, 2019
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4D05
 | | Structure and activity of a minimal-type ATP-dependent DNA ligase from a psychrotolerant bacterium | | Descriptor: | ADENOSINE MONOPHOSPHATE, ATP-DEPENDENT DNA LIGASE, MAGNESIUM ION, ... | | Authors: | Williamson, A, Rothweiler, U, Leiros, H.-K.S. | | Deposit date: | 2014-04-24 | | Release date: | 2014-11-12 | | Last modified: | 2019-06-26 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Enzyme-Adenylate Structure of a Bacterial ATP-Dependent DNA Ligase with a Minimized DNA-Binding Surface
Acta Crystallogr.,Sect.D, 70, 2014
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