4BKY

Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with pyrrolopyrazole inhibitor

Summary for 4BKY

Entry DOI	10.2210/pdb4bky/pdb
Related	4BKZ 4BL1
Descriptor	MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 3'-{[(4-bromo-1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-N-[(1S)-1-phenyl-2-(pyrrolidin-1-yl)ethyl]-1',4'-dihydro-5'H-spiro[cyclopropane-1,6'-pyrrolo[3,4-c]pyrazole]-5'-carboxamide, UNKNOWN ATOM OR ION, ... (4 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	40773.00
Authors	Canevari, G.,Re Depaolini, S.,Cucchi, U.,Forte, B.,Carpinelli, P.,Bertrand, J.A. (deposition date: 2013-04-30, release date: 2013-08-21, Last modification date: 2023-12-20)
Primary citation	Canevari, G.,Re Depaolini, S.,Cucchi, U.,Bertrand, J.A.,Casale, E.,Perrera, C.,Forte, B.,Carpinelli, P.,Felder, E.R. Structural Insight Into Maternal Embryonic Leucine Zipper Kinase (Melk) Conformation and Inhibition Towards Structure- Based Drug Design. Biochemistry, 52:6380-, 2013 Cited by PubMed: 23914841 DOI: 10.1021/BI4005864 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.83 Å)

Structure validation