4EG3

Trypanosoma brucei methionyl-tRNA synthetase in complex with product methionyl-adenylate

Summary for 4EG3

• Entry DOI: 10.2210/pdb4eg3/pdb
• Related: 4EG1 4EG4 4EG5 4EG6 4EG7 4EG8 4EGA
• Descriptor: Methionyl-tRNA synthetase, putative, GLYCEROL, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] (2S)-2-azanyl-4-methylsulfanyl-butanoate, ... (4 entities in total)
• Functional Keywords: aminoacyl-trna synthetase, aars, metrs, parasite, ligase, protein-inhibitor complex, rossmann-fold, translation, nucleotide binding, rossmann fold, trna binding atp binding
• Biological source: Trypanosoma brucei brucei
• Total number of polymer chains: 2
• Total formula weight: 124839.28

Authors

Koh, C.Y.,Kim, J.E.,Shibata, S.,Fan, E.,Verlinde, C.L.M.J.,Hol, W.G.J. (deposition date: 2012-03-30, release date: 2012-09-12, Last modification date: 2017-11-15)

• Primary citation: Koh, C.Y.,Kim, J.E.,Shibata, S.,Ranade, R.M.,Yu, M.,Liu, J.,Gillespie, J.R.,Buckner, F.S.,Verlinde, C.L.,Fan, E.,Hol, W.G.; Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.; Structure, 20:1681-1691, 2012; PubMed: 22902861; DOI: 10.1016/j.str.2012.07.011

Experimental method

X-RAY DIFFRACTION (2.94 Å)