1HFP
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![BU of 1hfp by Molmil](/molmil-images/mine/1hfp) | COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE | Descriptor: | DIHYDROFOLATE REDUCTASE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Cody, V, Galitsky, N, Luft, J.R, Pangborn, W, Blakley, R.L, Gangjee, A. | Deposit date: | 1997-11-04 | Release date: | 1998-01-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine. Anti-Cancer Drug Des., 13, 1998
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8EWG
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![BU of 8ewg by Molmil](/molmil-images/mine/8ewg) | Cryo-EM structure of a riboendonclease | Descriptor: | CRISPR-associated endonuclease Cas9, RNA (56-MER) | Authors: | Li, Z, Wang, F. | Deposit date: | 2022-10-23 | Release date: | 2023-08-30 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural Basis for the Ribonuclease Activity of a Thermostable CRISPR-Cas13a from Thermoclostridium caenicola. J.Mol.Biol., 435, 2023
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1HFR
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![BU of 1hfr by Molmil](/molmil-images/mine/1hfr) | COMPARISON OF TERNARY CRYSTAL COMPLEXES OF HUMAN DIHYDROFOLATE REDUCTASE WITH NADPH AND A CLASSICAL ANTITUMOR FUROPYRIMDINE | Descriptor: | DIHYDROFOLATE REDUCTASE, N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Cody, V, Galitsky, N, Luft, J.R, Pangborn, W, Blakley, R.L, Gangjee, A. | Deposit date: | 1997-11-04 | Release date: | 1998-01-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine. Anti-Cancer Drug Des., 13, 1998
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7MPR
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![BU of 7mpr by Molmil](/molmil-images/mine/7mpr) | Brucella melitensis NrnC | Descriptor: | NanoRNase C, SULFATE ION | Authors: | Lormand, J.D, Sondermann, H. | Deposit date: | 2021-05-04 | Release date: | 2021-09-15 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Structural characterization of NrnC identifies unifying features of dinucleotidases. Elife, 10, 2021
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4B3O
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![BU of 4b3o by Molmil](/molmil-images/mine/4b3o) | Structures of HIV-1 RT and RNA-DNA Complex Reveal a Unique RT Conformation and Substrate Interface | Descriptor: | (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE, 5'-D(*CP*GP*TP*AP*TP*GP*CP*CP*TP*AP*TP*AP*GP*TP *TP*AP*TP*TP*GP*TP*GP*GP*CP*C)-3', 5'-R(*AP*UP*GP*AP*3DRP*GP*GP*CP*CP*AP*CP*AP*AP*UP*AP *AP*CP*UP*AP*UP*AP*GP*GP*CP*AP*UP*A)-3', ... | Authors: | Lapkouski, M, Tian, L, Miller, J.T, Le Grice, S.F.J, Yang, W. | Deposit date: | 2012-07-25 | Release date: | 2013-01-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Complexes of HIV-1 RT, Nnrti and RNA/DNA Hybrid Reveal a Structure Compatible with RNA Degradation Nat.Struct.Mol.Biol., 20, 2013
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1ZBH
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![BU of 1zbh by Molmil](/molmil-images/mine/1zbh) | 3'-end specific recognition of histone mRNA stem-loop by 3'-exonuclease | Descriptor: | 3'-5' exonuclease ERI1, 5'-R(*CP*CP*GP*GP*CP*UP*CP*UP*UP*UP*UP*CP*AP*GP*AP*GP*CP*CP*GP*G)-3', ADENOSINE MONOPHOSPHATE, ... | Authors: | Cheng, Y, Patel, D.J. | Deposit date: | 2005-04-08 | Release date: | 2006-09-26 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for 3'-end specific recognition of histone mRNA stem-loop by 3'-exonuclease, a human nuclease that also targets siRNA To be Published
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6I1L
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![BU of 6i1l by Molmil](/molmil-images/mine/6i1l) | |
2L1V
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![BU of 2l1v by Molmil](/molmil-images/mine/2l1v) | |
2HVZ
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![BU of 2hvz by Molmil](/molmil-images/mine/2hvz) | Solution structure of the RRM domain of SR rich factor 9G8 | Descriptor: | Splicing factor, arginine/serine-rich 7 | Authors: | Tintaru, A.M, Hautbergue, G.M, Golovanov, A.P, Lian, L.Y, Wilson, S.A. | Deposit date: | 2006-07-31 | Release date: | 2006-11-21 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. Embo J., 25, 2006
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4B3G
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![BU of 4b3g by Molmil](/molmil-images/mine/4b3g) | crystal structure of Ighmbp2 helicase in complex with RNA | Descriptor: | DNA-BINDING PROTEIN SMUBP-2, RNA (5'-(AP*AP*AP*AP*AP*AP*AP*AP*AP)-3') | Authors: | Lim, S.C, Song, H. | Deposit date: | 2012-07-24 | Release date: | 2012-09-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | The Ighmbp2 Helicase Structure Reveals the Molecular Basis for Disease-Causing Mutations in Dmsa1. Nucleic Acids Res., 40, 2012
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3QX9
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![BU of 3qx9 by Molmil](/molmil-images/mine/3qx9) | Crystal structure of MID domain from hAGO2 in complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Protein argonaute-2 | Authors: | Frank, F, Fabian, M.R, Stepinski, J, Jemielity, J, Darzynkiewicz, E, Sonenberg, N, Nagar, B. | Deposit date: | 2011-03-01 | Release date: | 2011-04-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain. Embo Rep., 12, 2011
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6B4K
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![BU of 6b4k by Molmil](/molmil-images/mine/6b4k) | Crystal structure of human DDX19B(AMPPNP) | Descriptor: | ATP-dependent RNA helicase DDX19B, MAGNESIUM ION, MALONATE ION, ... | Authors: | Lin, D.H, Correia, A.R, Cai, S.W, Huber, F.M, Jette, C.A, Hoelz, A. | Deposit date: | 2017-09-26 | Release date: | 2018-06-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural and functional analysis of mRNA export regulation by the nuclear pore complex. Nat Commun, 9, 2018
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7KL3
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![BU of 7kl3 by Molmil](/molmil-images/mine/7kl3) | The crystal structure of the 2009/H1N1/California PA endonuclease mutant E119D bound to RNA oligomer AG*CAUC (*uncleaveable bond, -UC disordered) | Descriptor: | 5'-O-sulfocytidine, ADENOSINE MONOPHOSPHATE, GLYCEROL, ... | Authors: | Cuypers, M.G, Kumar, G, White, S.W. | Deposit date: | 2020-10-28 | Release date: | 2021-02-03 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism. Nucleic Acids Res., 49, 2021
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8DK7
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![BU of 8dk7 by Molmil](/molmil-images/mine/8dk7) | |
8D29
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![BU of 8d29 by Molmil](/molmil-images/mine/8d29) | |
4BRU
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![BU of 4bru by Molmil](/molmil-images/mine/4bru) | Crystal structure of the yeast Dhh1-Edc3 complex | Descriptor: | ATP-DEPENDENT RNA HELICASE DHH1, ENHANCER OF MRNA-DECAPPING PROTEIN 3 | Authors: | Sharif, H, Ozgur, S, Sharma, K, Basquin, C, Urlaub, H, Conti, E. | Deposit date: | 2013-06-05 | Release date: | 2013-07-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.245 Å) | Cite: | Structural Analysis of the Yeast Dhh1-Pat1 Complex Reveals How Dhh1 Engages Pat1, Edc3 and RNA in Mutually Exclusive Interactions Nucleic Acids Res., 41, 2013
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4H5C
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![BU of 4h5c by Molmil](/molmil-images/mine/4h5c) | Crystal structure of human FPPS in ternary complex with YS0470 and inorganic phosphate | Descriptor: | Farnesyl pyrophosphate synthase, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. | Deposit date: | 2012-09-18 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure. Bmc Struct.Biol., 12, 2012
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6B4J
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![BU of 6b4j by Molmil](/molmil-images/mine/6b4j) | Crystal structure of human Gle1 CTD-Nup42 GBM-DDX19B(AMPPNP) complex | Descriptor: | ATP-dependent RNA helicase DDX19B, MAGNESIUM ION, Nucleoporin GLE1, ... | Authors: | Lin, D.H, Correia, A.R, Cai, S.W, Huber, F.M, Jette, C.A, Hoelz, A. | Deposit date: | 2017-09-26 | Release date: | 2018-06-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural and functional analysis of mRNA export regulation by the nuclear pore complex. Nat Commun, 9, 2018
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7SOW
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![BU of 7sow by Molmil](/molmil-images/mine/7sow) | LaM domain of human LARP1 in complex with UUUUUU | Descriptor: | 1,2-ETHANEDIOL, Isoform 2 of La-related protein 1, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3') | Authors: | Kozlov, G, Gehring, K. | Deposit date: | 2021-11-01 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structural basis of 3'-end RNA recognition by LARP1 To Be Published
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5YAA
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![BU of 5yaa by Molmil](/molmil-images/mine/5yaa) | Crystal structure of Marf1 NYN domain from Mus musculus | Descriptor: | GLYCEROL, Meiosis regulator and mRNA stability factor 1 | Authors: | Yao, Q.Q, Wu, B.X, Ma, J.B. | Deposit date: | 2017-08-31 | Release date: | 2018-10-03 | Last modified: | 2018-11-14 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5ULP
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![BU of 5ulp by Molmil](/molmil-images/mine/5ulp) | Structure of the NS5 methyltransferase from Zika bound to MS2042 | Descriptor: | 5'-{[(3S)-3-amino-3-carboxypropyl][(4-fluorophenyl)methyl]amino}-5'-deoxyadenosine, CHLORIDE ION, ISOPROPYL ALCOHOL, ... | Authors: | Jain, R, Aggarwal, A.K. | Deposit date: | 2017-01-25 | Release date: | 2017-05-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase. Sci Rep, 7, 2017
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7LYS
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![BU of 7lys by Molmil](/molmil-images/mine/7lys) | Cryo-EM structure of CasPhi-2 (Cas12j) bound to crRNA and DNA | Descriptor: | CasPhi-2, NTS-DNA, TS-DNA, ... | Authors: | Pausch, P, Soczek, K, Nogales, E, Doudna, J. | Deposit date: | 2021-03-08 | Release date: | 2021-08-04 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | DNA interference states of the hypercompact CRISPR-Cas Phi effector. Nat.Struct.Mol.Biol., 28, 2021
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6YW5
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![BU of 6yw5 by Molmil](/molmil-images/mine/6yw5) | The structure of the small subunit of the mitoribosome from Neurospora crassa | Descriptor: | 16S rRNA, 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial, ... | Authors: | Amunts, A, Itoh, Y, Naschberger, A. | Deposit date: | 2020-04-29 | Release date: | 2020-11-11 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi. Nat Commun, 11, 2020
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6YYL
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![BU of 6yyl by Molmil](/molmil-images/mine/6yyl) | Crystal structure of S. pombe Mei2 RRM3 domain | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Meiosis protein mei2, ... | Authors: | Graille, M, Hazra, D. | Deposit date: | 2020-05-05 | Release date: | 2020-12-23 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | A scaffold lncRNA shapes the mitosis to meiosis switch. Nat Commun, 12, 2021
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2ZQQ
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![BU of 2zqq by Molmil](/molmil-images/mine/2zqq) | Crystal structure of human AUH (3-methylglutaconyl-coa hydratase) mixed with (AUUU)24A RNA | Descriptor: | Methylglutaconyl-CoA hydratase | Authors: | Kurimoto, K, Kuwasako, K, Muto, Y, Nureki, O, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2008-08-16 | Release date: | 2009-06-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | AU-rich RNA-binding induces changes in the quaternary structure of AUH Proteins, 75, 2009
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