7KL3
The crystal structure of the 2009/H1N1/California PA endonuclease mutant E119D bound to RNA oligomer AG*CAUC (*uncleaveable bond, -UC disordered)
Summary for 7KL3
Entry DOI | 10.2210/pdb7kl3/pdb |
Related | 6W7A 6WHM 6WS3 |
Descriptor | Protein PA-X, RNA (5'-R(P*AP*GP*CP*A)-3'), GLYCEROL, ... (7 entities in total) |
Functional Keywords | nuclease, influenza, inhibitor resistance, rna oligomer, uncleaveable bond, viral protein, viral protein-rna complex, viral protein/rna |
Biological source | Influenza A virus More |
Total number of polymer chains | 2 |
Total formula weight | 25964.23 |
Authors | Cuypers, M.G.,Kumar, G.,White, S.W. (deposition date: 2020-10-28, release date: 2021-02-03, Last modification date: 2024-05-29) |
Primary citation | Kumar, G.,Cuypers, M.,Webby, R.R.,Webb, T.R.,White, S.W. Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism. Nucleic Acids Res., 49:1609-1618, 2021 Cited by PubMed: 33469660DOI: 10.1093/nar/gkaa1294 PDB entries with the same primary citation |
Experimental method |
Structure validation
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