5ULP

Structure of the NS5 methyltransferase from Zika bound to MS2042

Summary for 5ULP

• Entry DOI: 10.2210/pdb5ulp/pdb
• Related: 5KQR 5KQS
• Descriptor: MRNA cap 0-1 NS5-type methyltransferase, 5'-{[(3S)-3-amino-3-carboxypropyl][(4-fluorophenyl)methyl]amino}-5'-deoxyadenosine, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: zika, flavivirus, ns5, methyltransferase, ms2042, sam analog, hydrolase
• Biological source: Zika virus (strain Mr 766) (ZIKV)
• Cellular location: Virion membrane ; Multi-pass membrane protein : B3U3M3
• Total number of polymer chains: 2
• Total formula weight: 60840.92

Authors

Jain, R.,Aggarwal, A.K. (deposition date: 2017-01-25, release date: 2017-05-17, Last modification date: 2023-10-04)

• Primary citation: Jain, R.,Butler, K.V.,Coloma, J.,Jin, J.,Aggarwal, A.K.; Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase.; Sci Rep, 7:1632-1632, 2017; PubMed: 28487506; DOI: 10.1038/s41598-017-01756-7

Experimental method

X-RAY DIFFRACTION (1.55 Å)