4FRE
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![BU of 4fre by Molmil](/molmil-images/mine/4fre) | Crystal Structure of BBBB+UDP+Gal at pH 6.5 with MPD as the cryoprotectant | Descriptor: | DI(HYDROXYETHYL)ETHER, Histo-blood group ABO system transferase, URIDINE-5'-DIPHOSPHATE, ... | Authors: | Johal, A.R, Alfaro, J.A, Blackler, R.J, Schuman, B, Borisova, S.N, Evans, S.V. | Deposit date: | 2012-06-26 | Release date: | 2013-12-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | pH-induced conformational changes in human ABO(H) blood group glycosyltransferases confirm the importance of electrostatic interactions in the formation of the semi-closed state. Glycobiology, 24, 2014
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3SWX
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4FRM
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![BU of 4frm by Molmil](/molmil-images/mine/4frm) | Crystal Structure of BBBB+UDP+Gal at pH 7.0 with MPD as the cryoprotectant | Descriptor: | Histo-blood group ABO system transferase, URIDINE-5'-DIPHOSPHATE, beta-D-galactopyranose | Authors: | Johal, A.R, Alfaro, J.A, Blackler, R.J, Schuman, B, Borisova, S.N, Evans, S.V. | Deposit date: | 2012-06-26 | Release date: | 2013-12-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | pH-induced conformational changes in human ABO(H) blood group glycosyltransferases confirm the importance of electrostatic interactions in the formation of the semi-closed state. Glycobiology, 24, 2014
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3CZC
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3TE2
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![BU of 3te2 by Molmil](/molmil-images/mine/3te2) | Crystal structure of HSC K16S | Descriptor: | TETRAETHYLENE GLYCOL, formate/nitrite transporter, octyl beta-D-glucopyranoside | Authors: | Czyzewski, B.K, Wang, D.-N. | Deposit date: | 2011-08-11 | Release date: | 2012-03-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification and characterization of a bacterial hydrosulphide ion channel. Nature, 483, 2012
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2PC0
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![BU of 2pc0 by Molmil](/molmil-images/mine/2pc0) | Apo Wild-type HIV Protease in the open conformation | Descriptor: | MAGNESIUM ION, Protease, R-1,2-PROPANEDIOL | Authors: | Heaslet, H, Rosenfeld, R, Giffin, M.J, Elder, J.H, McRee, D.E, Stout, C.D. | Deposit date: | 2007-03-29 | Release date: | 2007-06-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Conformational flexibility in the flap domains of ligand-free HIV protease. Acta Crystallogr.,Sect.D, 63, 2007
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3D0Q
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![BU of 3d0q by Molmil](/molmil-images/mine/3d0q) | Crystal structure of calG3 from Micromonospora echinospora determined in space group I222 | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Protein CalG3 | Authors: | Bitto, E, Singh, S, Bingman, C.A, Wesenberg, G.E, Phillips Jr, G.N. | Deposit date: | 2008-05-02 | Release date: | 2008-06-24 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis. Chem.Biol., 15, 2008
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4FKY
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![BU of 4fky by Molmil](/molmil-images/mine/4fky) | |
4FPF
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4FOX
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![BU of 4fox by Molmil](/molmil-images/mine/4fox) | Crystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, Thymidylate synthase | Authors: | Reddy, M.C.M, Bruning, J.B, Sacchettini, J.C, Harshbarger, W, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2012-06-21 | Release date: | 2013-08-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of binary and ternary complexes of thymidylate synthase (ThyA) from Mycobacterium tuberculosis: Insights into the selectivity and mode of inhibition To be Published
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4D83
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![BU of 4d83 by Molmil](/molmil-images/mine/4d83) | Crystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a co-crystallization experiment | Descriptor: | (3R,4S,5S)-3-[(3-tert-butylbenzyl)amino]-5-{[3-(2,2-difluoroethyl)-1H-indol-5-yl]methyl}tetrahydro-2H-thiopyran-4-ol 1,1-dioxide, Beta-secretase 1 | Authors: | Rondeau, J.M, Bourgier, E. | Deposit date: | 2012-01-10 | Release date: | 2012-11-21 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery of cyclic sulfone hydroxyethylamines as potent and selective beta-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloid beta-peptides J.Med.Chem., 55, 2012
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4D8N
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2PEQ
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![BU of 2peq by Molmil](/molmil-images/mine/2peq) | Crystal structure of RbcX, crystal form II | Descriptor: | ORF134 | Authors: | Saschenbrecker, S, Bracher, A, Vasudeva Rao, K, Vasudeva Rao, B, Hartl, F.U, Hayer-Hartl, M. | Deposit date: | 2007-04-03 | Release date: | 2007-07-10 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure and Function of RbcX, an Assembly Chaperone for Hexadecameric Rubisco. Cell(Cambridge,Mass.), 129, 2007
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4D9U
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![BU of 4d9u by Molmil](/molmil-images/mine/4d9u) | Rsk2 C-terminal Kinase Domain, (E)-tert-butyl 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyanoacrylate | Descriptor: | Ribosomal protein S6 kinase alpha-3, SODIUM ION, tert-butyl (2S)-3-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyanopropanoate | Authors: | Serafimova, I.M, Pufall, M.A, Krishnan, S, Duda, K, Cohen, M.S, Maglathlin, R.L, McFarland, J.M, Miller, R.M, Frodin, M, Taunton, J. | Deposit date: | 2012-01-12 | Release date: | 2012-04-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles. Nat.Chem.Biol., 8, 2012
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3D4M
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![BU of 3d4m by Molmil](/molmil-images/mine/3d4m) | Glutaredoxin 2 oxidized structure | Descriptor: | Glutaredoxin-2, mitochondrial | Authors: | Discola, K.F, de Oliveira, M.A, Barcena, J.A, Porras, P, Guimaraes, B.G, Netto, L.E.S. | Deposit date: | 2008-05-14 | Release date: | 2008-10-28 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural aspects of the distinct biochemical properties of glutaredoxin 1 and glutaredoxin 2 from Saccharomyces cerevisiae. J.Mol.Biol., 385, 2009
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2P0G
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![BU of 2p0g by Molmil](/molmil-images/mine/2p0g) | Crystal structure of Selenoprotein W-related protein from Vibrio cholerae. Northeast Structural Genomics target VcR75 | Descriptor: | Selenoprotein W-related protein | Authors: | Benach, J, Neely, H, Seetharaman, J, Ho, C.K, Janjua, H, Cunningham, K, Ma, L, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-02-28 | Release date: | 2007-03-20 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of Selenoprotein W-related protein from Vibrio cholerae. To be Published
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2GHP
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![BU of 2ghp by Molmil](/molmil-images/mine/2ghp) | Crystal structure of the N-terminal 3 RNA binding domains of the yeast splicing factor Prp24 | Descriptor: | U4/U6 snRNA-associated splicing factor PRP24 | Authors: | Bae, E, Wesenberg, G.E, Phillips Jr, G.N, Bitto, E, Bingman, C.A, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2006-03-27 | Release date: | 2006-04-25 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure and interactions of the first three RNA recognition motifs of splicing factor prp24. J.Mol.Biol., 367, 2007
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2P0Y
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![BU of 2p0y by Molmil](/molmil-images/mine/2p0y) | Crystal structure of Q88YI3_LACPL from Lactobacillus plantarum. Northeast Structural Genomics Consortium target LpR6 | Descriptor: | Hypothetical protein lp_0780 | Authors: | Benach, J, Chen, Y, Seetharaman, J, Chi, K.H, Janjua, H, Cunningham, K, Ma, L.C, Xiao, R, Liu, J, Baran, M.C, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2007-03-01 | Release date: | 2007-03-27 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of Q88YI3_LACPL from Lactobacillus plantarum. To be Published
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4FU6
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![BU of 4fu6 by Molmil](/molmil-images/mine/4fu6) | Crystal structure of the PSIP1 PWWP domain | Descriptor: | GLYCEROL, PC4 and SFRS1-interacting protein, SULFATE ION, ... | Authors: | Qin, S, Tempel, W, Xu, C, Wu, H, Dong, A, Cerovina, T, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2012-06-28 | Release date: | 2012-08-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and function of the nucleosome-binding PWWP domain. Trends Biochem.Sci., 39, 2014
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3T4P
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4FUP
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3T8J
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![BU of 3t8j by Molmil](/molmil-images/mine/3t8j) | Structural analysis of thermostable S. solfataricus pyrimidine-specific nucleoside hydrolase | Descriptor: | Purine nucleosidase, (IunH-1), SODIUM ION | Authors: | Minici, C, Cacciapuoti, G, De Leo, E, Porcelli, M, Degano, M. | Deposit date: | 2011-08-01 | Release date: | 2012-05-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | New Determinants in the Catalytic Mechanism of Nucleoside Hydrolases from the Structures of Two Isozymes from Sulfolobus solfataricus. Biochemistry, 51, 2012
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2P1E
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![BU of 2p1e by Molmil](/molmil-images/mine/2p1e) | Crystal structure of the Leishmania infantum glyoxalase II with D-Lactate at the active site | Descriptor: | Glyoxalase II, LACTIC ACID, SPERMIDINE, ... | Authors: | Trincao, J, Barata, L, Najmudin, S, Bonifacio, C, Romao, M.J. | Deposit date: | 2007-03-05 | Release date: | 2008-01-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Catalysis and Structural Properties of Leishmania infantum Glyoxalase II: Trypanothione Specificity and Phylogeny. Biochemistry, 47, 2008
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2P2J
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![BU of 2p2j by Molmil](/molmil-images/mine/2p2j) | Acetyl-CoA Synthetase, K609A mutation | Descriptor: | ADENOSINE-5'-MONOPHOSPHATE-PROPYL ESTER, Acetyl-coenzyme A synthetase, COENZYME A | Authors: | Reger, A.S, Gulick, A.M. | Deposit date: | 2007-03-07 | Release date: | 2007-05-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Biochemical and Crystallographic Analysis of Substrate Binding and Conformational Changes in Acetyl-CoA Synthetase. Biochemistry, 46, 2007
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3T6P
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![BU of 3t6p by Molmil](/molmil-images/mine/3t6p) | IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization | Descriptor: | Baculoviral IAP repeat-containing protein 2, ZINC ION | Authors: | Dueber, E.C, Schoeffler, A.J, Lingel, A, Elliott, M, Fedorova, A.V, Giannetti, A.M, Zobel, K, Maurer, B, Varfolomeev, E, Wu, P, Wallweber, H, Hymowitz, S, Deshayes, K, Vucic, D, Fairbrother, W.J. | Deposit date: | 2011-07-28 | Release date: | 2011-11-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.897 Å) | Cite: | Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. Science, 334, 2011
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