PDB: 97814 resultsInfo pagesStatus searchChemie searchBIRD

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4V94	Molecular architecture of the eukaryotic chaperonin TRiC/CCT derived by a combination of chemical crosslinking and mass-spectrometry, XL-MS Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... Authors: Leitner, A, Joachimiak, L.A, Bracher, A, Walzthoeni, T, Chen, B, Monkemeyer, L, Pechmann, S, Holmes, S, Cong, Y, Ma, B, Ludtke, S, Chiu, W, Hartl, F.U, Aebersold, R, Frydman, J. Deposit date: 2012-01-11 Release date: 2014-07-09 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.8 Å) Cite: The Molecular Architecture of the Eukaryotic Chaperonin TRiC/CCT. Structure, 20, 2012
6W45	Crystal structure of HAO1 in complex with biaryl acid inhibitor - compound 3 Descriptor: 2-chloranyl-4-[2-[[(6-chloranyl-1~{H}-indol-2-yl)carbonyl-methyl-amino]methyl]-5-fluoranyl-phenyl]benzoic acid, FLAVIN MONONUCLEOTIDE, Hydroxyacid oxidase 1 Authors: Ferguson, A.D. Deposit date: 2020-03-10 Release date: 2021-05-12 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening. J.Med.Chem., 64, 2021
6CTS	PROPOSED MECHANISM FOR THE CONDENSATION REACTION OF CITRATE SYNTHASE. 1.9-ANGSTROMS STRUCTURE OF THE TERNARY COMPLEX WITH OXALOACETATE AND CARBOXYMETHYL COENZYME A Descriptor: CITRATE SYNTHASE, CITRYL-THIOETHER-COENZYME *A Authors: Karpusas, M, Branchaud, B, Remington, S.J. Deposit date: 1989-11-16 Release date: 1990-10-15 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Proposed mechanism for the condensation reaction of citrate synthase: 1.9-A structure of the ternary complex with oxaloacetate and carboxymethyl coenzyme A. Biochemistry, 29, 1990
3EQI	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ADP and MG2P Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Fischmann, T.O. Deposit date: 2008-09-30 Release date: 2009-02-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3EQC	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with compound 1, ATP-GS AND MG2P Descriptor: 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide, CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, ... Authors: Fischmann, T.O. Deposit date: 2008-09-30 Release date: 2009-02-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3EQF	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with K252A and MG2P Descriptor: CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, K-252A, ... Authors: Fischmann, T.O. Deposit date: 2008-09-30 Release date: 2009-02-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3EQH	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with U0126, ADP and MG2P Descriptor: (2Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... Authors: Fischmann, T.O. Deposit date: 2008-09-30 Release date: 2009-02-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3N78	SgrAI bound to Secondary Site DNA and Mg(II) Descriptor: DNA (5'-D(*AP*GP*TP*CP*CP*AP*CP*CP*GP*GP*GP*GP*GP*AP*CP*T)-3'), DNA (5'-D(*AP*GP*TP*CP*CP*CP*CP*CP*GP*GP*TP*GP*GP*AP*CP*T)-3'), MAGNESIUM ION, ... Authors: Horton, N.C, Little, E.J, Dunten, P.W. Deposit date: 2010-05-26 Release date: 2010-11-24 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.95 Å) Cite: New clues in the allosteric activation of DNA cleavage by SgrAI: structures of SgrAI bound to cleaved primary-site DNA and uncleaved secondary-site DNA. Acta Crystallogr.,Sect.D, 67, 2011
7OTQ	Cryo-EM structure of ALC1/CHD1L bound to a PARylated nucleosome Descriptor: Chromodomain-helicase-DNA-binding protein 1-like, DNA (149-MER) Widom 601 sequence, Histone H2A type 1, ... Authors: Bacic, L, Gaullier, G, Deindl, S. Deposit date: 2021-06-10 Release date: 2021-09-15 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome Elife, 10, 2021
3FX4	Porcine aldehyde reductase in ternary complex with inhibitor Descriptor: Alcohol dehydrogenase [NADP+], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... Authors: Carbone, V, El-Kabbani, O. Deposit date: 2009-01-20 Release date: 2009-12-22 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.99 Å) Cite: Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor. Eur.J.Med.Chem., 45, 2010
7AZY	Context-specific inhibition of eukaryotic translation by macrolide antibiotics Descriptor: 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... Authors: Koller, T.O, Wilson, D.N. Deposit date: 2020-11-17 Release date: 2021-05-19 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (2.877 Å) Cite: Context-specific action of macrolide antibiotics on the eukaryotic ribosome. Nat Commun, 12, 2021
2CSC	Structure of ternary complexes of CITRATE SYNTHASE WITH D-AND L-MALATE: mechanistic implications Descriptor: CARBOXYMETHYL COENZYME *A, CITRATE SYNTHASE, D-MALATE Authors: Karpusas, M, Holland, D, Remington, S.J. Deposit date: 1990-05-07 Release date: 1991-04-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: 1.9-A structures of ternary complexes of citrate synthase with D- and L-malate: mechanistic implications. Biochemistry, 30, 1991
2IHQ	Crystal Structure of the Rat Androgen Receptor Ligand Binding Domian Complex with an N-Aryl-Hydroxybicyclohydantoin Descriptor: 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE, Androgen receptor Authors: Sack, J.S. Deposit date: 2006-09-27 Release date: 2006-12-12 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold. J.Med.Chem., 49, 2006
6D9X	Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design Descriptor: 2-phenyl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole, SODIUM ION, WD repeat-containing protein 5 Authors: Phan, J, Fesik, S.W. Deposit date: 2018-04-30 Release date: 2018-09-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. J. Med. Chem., 61, 2018
3KTQ	CRYSTAL STRUCTURE OF AN ACTIVE TERNARY COMPLEX OF THE LARGE FRAGMENT OF DNA POLYMERASE I FROM THERMUS AQUATICUS Descriptor: 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*DOC)-3'), ... Authors: Li, Y, Waksman, G. Deposit date: 1998-07-28 Release date: 1999-01-13 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation. EMBO J., 17, 1998
6DAI	Discovery of Potent 2-Aryl-6,7-Dihydro-5HPyrrolo[ 1,2-a]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design Descriptor: 6-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-2-yl)-1-methylindoline, DIMETHYL SULFOXIDE, WD repeat-containing protein 5 Authors: Phan, J, Fesik, S.W. Deposit date: 2018-05-01 Release date: 2018-09-05 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. J. Med. Chem., 61, 2018
7OLD	Thermophilic eukaryotic 80S ribosome at pe/E (TI)-POST state Descriptor: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... Authors: Kisonaite, M, Wild, K, Sinning, I. Deposit date: 2021-05-19 Release date: 2022-01-26 Last modified: 2022-02-09 Method: ELECTRON MICROSCOPY (3 Å) Cite: High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation. Nat Commun, 13, 2022
7OLC	Thermophilic eukaryotic 80S ribosome at idle POST state Descriptor: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... Authors: Kisonaite, M, Wild, K, Sinning, I. Deposit date: 2021-05-19 Release date: 2022-01-26 Last modified: 2022-04-06 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation. Nat Commun, 13, 2022
6YLV	Translation initiation factor 4E in complex with 4-Cl-Bn7GpppG mRNA 5' cap analog Descriptor: 4-Cl-Bn7GpppG mRNA 5' cap analog, Eukaryotic translation initiation factor 4E, GLYCEROL Authors: Kubacka, D, Wojcik, R, Baranowski, M.R, Kowalska, J, Jemielity, J. Deposit date: 2020-04-07 Release date: 2020-06-10 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.66005659 Å) Cite: Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation. Pharmaceutics, 13, 2021
8BN3	Yeast 80S, ES7s delta, eIF5A, Stm1 containing Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ... Authors: Dimitrova-Paternoga, L, Paternoga, H, Wilson, D.N. Deposit date: 2022-11-12 Release date: 2024-01-10 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (2.4 Å) Cite: Evolving precision: rRNA expansion segment 7S modulates translation velocity and accuracy in eukaryal ribosomes. Nucleic Acids Res., 52, 2024
4UYJ	Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation Descriptor: SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN, SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN, SRP RNA Authors: Bousset, L, Mary, C, Brooks, M.A, Scherrer, A, Strub, K, Cusack, S. Deposit date: 2014-09-01 Release date: 2014-11-05 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Crystal Structure of a Signal Recognition Particle Alu Domain in the Elongation Arrest Conformation. RNA, 20, 2014
4UYK	Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation Descriptor: SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN, SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN, SRP RNA Authors: Bousset, L, Mary, C, Brooks, M.A, Scherrer, A, Strub, K, Cusack, S. Deposit date: 2014-09-01 Release date: 2014-11-05 Last modified: 2014-12-03 Method: X-RAY DIFFRACTION (3.22 Å) Cite: Crystal Structure of a Signal Recognition Particle Alu Domain in the Elongation Arrest Conformation. RNA, 20, 2014
8AGT	Yeast RQC complex in state F Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Tesina, P, Buschauer, R, Beckmann, R. Deposit date: 2022-07-20 Release date: 2023-03-08 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol.Cell, 83, 2023
8AGZ	Yeast RQC complex in state with the RING domain of Ltn1 in the OUT position Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Tesina, P, Buschauer, R, Beckmann, R. Deposit date: 2022-07-20 Release date: 2023-03-08 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol.Cell, 83, 2023
8AAF	Yeast RQC complex in state G Descriptor: 25S rRNA, 5.8S rRNA, 5S rRNA, ... Authors: Tesina, P, Buschauer, R, Beckmann, R. Deposit date: 2022-07-01 Release date: 2023-03-08 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Molecular basis of eIF5A-dependent CAT tailing in eukaryotic ribosome-associated quality control. Mol.Cell, 83, 2023

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