4CQ0
Cyclic secondary sulfonamides: unusually good inhibitors of cancer- related carbonic anhydrase enzymes
Summary for 4CQ0
| Entry DOI | 10.2210/pdb4cq0/pdb |
| Descriptor | CARBONIC ANHYDRASE 2, ZINC ION, FORMIC ACID, ... (5 entities in total) |
| Functional Keywords | lyase, saccharin, click chemistry, drug design |
| Biological source | HOMO SAPIENS (HUMAN) |
| Total number of polymer chains | 1 |
| Total formula weight | 29598.70 |
| Authors | Moeker, J.,Peat, T.S.,Bornaghi, L.F.,Vullo, D.,Supuran, C.T.,Poulsen, S. (deposition date: 2014-02-10, release date: 2014-04-16, Last modification date: 2023-12-20) |
| Primary citation | Moeker, J.,Peat, T.S.,Bornaghi, L.F.,Vullo, D.,Supuran, C.T.,Poulsen, S. Cyclic Secondary Sulfonamides: Unusually Good Inhibitors of Cancer-Related Carbonic Anhydrase Enzymes. J.Med.Chem., 57:3522-, 2014 Cited by PubMed: 24689792DOI: 10.1021/JM500255Y PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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