3DWZ
| Meropenem Covalent Adduct with TB Beta-lactamase | Descriptor: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase, PHOSPHATE ION | Authors: | Tremblay, L.W, Hugonnet, J.E, Blanchard, J.S. | Deposit date: | 2008-07-23 | Release date: | 2009-03-10 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis Science, 323, 2009
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3DW0
| Crystal structure of the class A carbapenemase KPC-2 at 1.6 angstrom resolution | Descriptor: | Class A carbapenemase KPC-2 | Authors: | Petrella, S, Ziental-Gelus, N, Mayer, C, Jarlier, V, Sougakoff, W. | Deposit date: | 2008-07-21 | Release date: | 2008-07-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France. Antimicrob.Agents Chemother., 52, 2008
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3DTM
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3D4F
| SHV-1 beta-lactamase complex with LN1-255 | Descriptor: | (3R)-4-{[(3,4-dihydroxyphenyl)acetyl]oxy}-N-(2-formylindolizin-3-yl)-3-sulfino-D-valine, Beta-lactamase SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE | Authors: | Pattanaik, P, Bethel, C.R, Hujer, A.M, Bonomo, R.A, Buynak, J.D, van den Akker, F. | Deposit date: | 2008-05-14 | Release date: | 2009-02-10 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Strategic Design of an Effective {beta}-Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONE J.Biol.Chem., 284, 2009
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3CMZ
| TEM-1 Class-A beta-lactamase L201P mutant apo structure | Descriptor: | Beta-lactamase TEM, PHOSPHATE ION | Authors: | Marciano, D.C, Wang, X, Wang, J, Chen, Y, Thomas, V.L, Shoichet, B.K, Palzkill, T. | Deposit date: | 2008-03-24 | Release date: | 2008-11-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase J.Mol.Biol., 384, 2008
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3CG5
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3C7V
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3C7U
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3C5A
| Crystal structure of the C-terminal deleted mutant of the class A carbapenemase KPC-2 at 1.23 angstrom | Descriptor: | CITRIC ACID, Class A carbapenemase KPC-2 | Authors: | Petrella, S, Ziental-Gelus, N, Mayer, C, Jarlier, V, Sougakoff, W. | Deposit date: | 2008-01-31 | Release date: | 2008-08-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | Genetic and structural insights into the dissemination potential of the extremely-broad-spectrum class A {beta}-lactamase (EBSBL) KPC-2 identified in two strains of Escherichia coli and Enterobacter cloacae isolated from the same patient in France ANTIMICROB.AGENTS CHEMOTHER., 2008
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3C4P
| Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) E73M complex | Descriptor: | Beta-lactamase SHV-1, Beta-lactamase inhibitory protein, SULFATE ION | Authors: | Reynolds, K.A, Hanes, M.S, Thomson, J.M, Antczak, A.J, Berger, J.M, Bonomo, R.A, Kirsch, J.F, Handel, T.M. | Deposit date: | 2008-01-30 | Release date: | 2008-05-27 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface. J.Mol.Biol., 382, 2008
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3C4O
| Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) E73M/S130K/S146M complex | Descriptor: | Beta-lactamase SHV-1, Beta-lactamase inhibitory protein, SULFATE ION | Authors: | Reynolds, K.A, Hanes, M.S, Thomson, J.M, Antczak, A.J, Berger, J.M, Bonomo, R.A, Kirsch, J.F, Handel, T.M. | Deposit date: | 2008-01-30 | Release date: | 2008-05-27 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface. J.Mol.Biol., 382, 2008
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3BYD
| Crystal structure of beta-lactamase OXY-1-1 from Klebsiella oxytoca | Descriptor: | ACETATE ION, Beta-lactamase OXY-1, SULFATE ION | Authors: | Liang, Y.-H, Wu, S.W, Su, X.-D. | Deposit date: | 2008-01-15 | Release date: | 2009-01-20 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structural insights into the broadened substrate profile of the extended-spectrum beta-lactamase OXY-1-1 from Klebsiella oxytoca Acta Crystallogr.,Sect.D, 68, 2012
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3BM6
| AmpC beta-lactamase in complex with a p.carboxyphenylboronic acid | Descriptor: | 4-(dihydroxyboranyl)-2-({[4-(phenylsulfonyl)thiophen-2-yl]sulfonyl}amino)benzoic acid, Beta-lactamase | Authors: | Tondi, D. | Deposit date: | 2007-12-12 | Release date: | 2009-02-17 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural study of phenyl boronic acid derivatives as AmpC beta-lactamase inhibitors. Bioorg.Med.Chem.Lett., 20, 2010
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3BLS
| AMPC BETA-LACTAMASE FROM ESCHERICHIA COLI | Descriptor: | AMPC BETA-LACTAMASE, M-AMINOPHENYLBORONIC ACID | Authors: | Usher, K.C, Shoichet, B.K, Remington, S.J. | Deposit date: | 1998-06-04 | Release date: | 1998-08-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Three-dimensional structure of AmpC beta-lactamase from Escherichia coli bound to a transition-state analogue: possible implications for the oxyanion hypothesis and for inhibitor design. Biochemistry, 37, 1998
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3BLM
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3BFG
| class A beta-lactamase SED-G238C complexed with meropenem | Descriptor: | (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, Class A beta-lactamase Sed1 | Authors: | Pernot, L, Petrella, S, Sougakoff, W. | Deposit date: | 2007-11-21 | Release date: | 2007-12-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | acyl-intermediate structures of the class A beta-lactamase SED-G238C To be Published
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3BFF
| class A beta-lactamase SED-G238C complexed with faropenem | Descriptor: | (2R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-5-[(2R)-oxolan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid, (5R,6S)-6-(1-hydroxyethyl)-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, Class A beta-lactamase Sed1, ... | Authors: | Pernot, L, Petrella, S, Sougakoff, W. | Deposit date: | 2007-11-21 | Release date: | 2007-12-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | acyl-intermediate structures of the class A beta-lactamase SED-G238C To be Published
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3BFE
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3BFD
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3BFC
| class A beta-lactamase SED-G238C complexed with imipenem | Descriptor: | (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, Class A beta-lactamase Sed1 | Authors: | Pernot, L, Petrella, S, Sougakoff, W. | Deposit date: | 2007-11-21 | Release date: | 2007-12-18 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Acyl-intermediate structures of the class A beta-lactamase SED-G238C To be Published
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3B3X
| Crystal structure of class A beta-lactamase of Bacillus licheniformis BS3 with aminocitrate | Descriptor: | 2-(carboxymethyl)-D-aspartic acid, Beta-lactamase | Authors: | Sauvage, E, Herman, R, Kerff, F, Charlier, P. | Deposit date: | 2007-10-23 | Release date: | 2007-11-13 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | 2-Aminopropane-1,2,3-tricarboxylic acid: Synthesis and co-crystallization with the class A beta-lactamase BS3 of Bacillus licheniformis Bioorg.Med.Chem.Lett., 18, 2008
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3A66
| Crystal structure of 6-aminohexanoate-dimer hydrolase S112A/G181D/H266N/D370Y mutant with substrate | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOATE-DIMER HYDROLASE, 6-AMINOHEXANOIC ACID, ... | Authors: | Kawashima, Y, Shibata, N, Higuchi, Y, Takeo, M, Negoro, S. | Deposit date: | 2009-08-21 | Release date: | 2010-09-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Enzymatic Synthesis of Nylon-6 Units in Organic Sol Contained Low-Water: Structural Requirement of 6-Aminohexanoate-Dimer Hydrolase for Efficient Amid Synthesis To be Published
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3A65
| Crystal structure of 6-aminohexanoate-dimer hydrolase S112A/G181D/H266N mutant with substrate | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ... | Authors: | Kawashima, Y, Shibata, N, Higuchi, Y, Takeo, M, Negoro, S. | Deposit date: | 2009-08-21 | Release date: | 2010-09-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Enzymatic Synthesis of Nylon-6 Units in Organic Sol Contained Low-Water: Structural Requirement of 6-Aminohexanoate-Dimer Hydrolase for Efficient Amid Synthesis To be Published
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2ZQD
| Ceftazidime acyl-intermediate structure of class a beta-lact Toho-1 E166A/R274N/R276N triple mutant | Descriptor: | ACYLATED CEFTAZIDIME, Beta-lactamase Toho-1, SULFATE ION | Authors: | Nitanai, Y, Shimamura, T, Uchiyama, T, Ishii, Y, Takehira, M, Yutani, K, Matsuzawa, H, Miyano, M. | Deposit date: | 2008-08-07 | Release date: | 2009-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.19 Å) | Cite: | Structural Basis of Extend Spectrum Beta-Lactamase in Correlation of Enzymatic Kinetics and Thermal Stability of Acyl-Intermediates To be Published
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2ZQC
| Aztreonam acyl-intermediate structure of class a beta-lactam Toho-1 E166A/R274N/R276N triple mutant | Descriptor: | 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid, Beta-lactamase Toho-1, SULFATE ION | Authors: | Nitanai, Y, Shimamura, T, Uchiyama, T, Ishii, Y, Takehira, M, Yutani, K, Matsuzawa, H, Miyano, M. | Deposit date: | 2008-08-07 | Release date: | 2009-07-28 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.07 Å) | Cite: | Structural Basis of Extend Spectrum Beta-Lactamase in Correlation of Enzymatic Kinetics and Thermal Stability of Acyl-Intermediates To be Published
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