2ZQD

Ceftazidime acyl-intermediate structure of class a beta-lact Toho-1 E166A/R274N/R276N triple mutant

Summary for 2ZQD

• Entry DOI: 10.2210/pdb2zqd/pdb
• Related: 2ZQ7 2ZQ8 2ZQ9 2ZQA 2ZQC
• Descriptor: Beta-lactamase Toho-1, SULFATE ION, ACYLATED CEFTAZIDIME, ... (4 entities in total)
• Functional Keywords: extended-spectrum, esbl, beta-lactamase, acyl-enzyme complex, ceftazidime, toho-1, hydrolase, antibiotic resistance, plasmid
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 28971.50

Authors

Nitanai, Y.,Shimamura, T.,Uchiyama, T.,Ishii, Y.,Takehira, M.,Yutani, K.,Matsuzawa, H.,Miyano, M. (deposition date: 2008-08-07, release date: 2009-07-28, Last modification date: 2023-11-01)

• Primary citation: Nitanai, Y.,Shimamura, T.,Uchiyama, T.,Ishii, Y.,Takehira, M.,Yutan, K.,Matsuzawa, H.,Miyano, M.; Structural Basis of Extend Spectrum Beta-Lactamase in Correlation of Enzymatic Kinetics and Thermal Stability of Acyl-Intermediates; To be Published,

Experimental method

X-RAY DIFFRACTION (1.19 Å)