2ZQC

Aztreonam acyl-intermediate structure of class a beta-lactam Toho-1 E166A/R274N/R276N triple mutant

Summary for 2ZQC

• Entry DOI: 10.2210/pdb2zqc/pdb
• Related: 2ZQ7 2ZQ8 2ZQ9 2ZQA 2ZQD
• Descriptor: Beta-lactamase Toho-1, SULFATE ION, 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid, ... (4 entities in total)
• Functional Keywords: extended-spectrum, esbl, beta-lactamase, acyl-enzyme complex, aztreonam, toho-1, hydrolase, antibiotic resistance
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 28939.45

Authors

Nitanai, Y.,Shimamura, T.,Uchiyama, T.,Ishii, Y.,Takehira, M.,Yutani, K.,Matsuzawa, H.,Miyano, M. (deposition date: 2008-08-07, release date: 2009-07-28, Last modification date: 2023-11-01)

• Primary citation: Nitanai, Y.,Shimamura, T.,Uchiyama, T.,Ishii, Y.,Takehira, M.,Yutan, K.,Matsuzawa, H.,Miyano, M.; Structural Basis of Extend Spectrum Beta-Lactamase in Correlation of Enzymatic Kinetics and Thermal Stability of Acyl-Intermediates; To be Published,

Experimental method

X-RAY DIFFRACTION (1.07 Å)