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CRYSTAL STRUCTURE OF AN IN VIVO HIV-1 PROTEASE MUTANT IN COMPLEX WITH SAQUINAVIR: INSIGHTS INTO THE MECHANISMS OF DRUG RESISTANCE
Descriptor:	(2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, HIV-1 PROTEASE
Authors:	Hong, L, Zhang, X.C, Hartsuck, J.A, Tang, J.
Deposit date:	2000-07-14
Release date:	2000-12-13
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: insights into the mechanisms of drug resistance. Protein Sci., 9, 2000

1FFF

STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE : HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
Descriptor:	N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, PROTEASE RETROPEPSIN
Authors:	Mahalingam, B, Louis, J.M, Harrison, R.W, Weber, I.T.
Deposit date:	2000-07-25
Release date:	2001-06-01
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes. Proteins, 43, 2001

1FEJ

STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:	N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, PROTEASE RETROPEPSIN
Authors:	Mahalingam, B, Louis, J.M, Harrison, R.W, Weber, I.T.
Deposit date:	2000-07-21
Release date:	2001-06-01
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.78 Å)
Cite:	Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes. Proteins, 43, 2001

1FG6

STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:	N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, PROTEASE RETROPEPSIN
Authors:	Mahalingam, B, Louis, J.M, Harrison, R.W, Weber, I.T.
Deposit date:	2000-07-25
Release date:	2001-06-01
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes. Proteins, 43, 2001

1IDA

CRYSTAL STRUCTURES OF HIV-2 PROTEASE IN COMPLEX WITH INHIBITORS CONTAINING THE HYDROXYETHYLAMINE DIPEPTIDE ISOSTERE
Descriptor:	N-[(1R)-1-{[(1S,2S)-1-benzyl-3-{(2R,4S)-2-(tert-butylcarbamoyl)-4-[(pyridin-3-ylmethyl)sulfanyl]piperidin-1-yl}-2-hydroxypropyl]carbamoyl}-2-methylpropyl]quinoline-2-carboxamide, Protease
Authors:	Tong, L, Anderson, P.C.
Deposit date:	1994-10-19
Release date:	1995-01-26
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere. Structure, 3, 1995

1GNN

HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASN (V82N) COMPLEXED WITH U89360E (INHIBITOR)
Descriptor:	HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
Authors:	Hong, L, Treharne, A, Hartsuck, J.A, Foundling, S, Tang, J.
Deposit date:	1996-05-04
Release date:	1996-11-08
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases. Biochemistry, 35, 1996

1GNM

HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASP (V82D) COMPLEXED WITH U89360E (INHIBITOR)
Descriptor:	HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
Authors:	Hong, L, Treharne, A, Hartsuck, J.A, Foundling, S, Tang, J.
Deposit date:	1996-05-04
Release date:	1996-11-08
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal structures of complexes of a peptidic inhibitor with wild-type and two mutant HIV-1 proteases. Biochemistry, 35, 1996

1FF0

STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES.
Descriptor:	N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, PROTEASE RETROPEPSIN
Authors:	Mahalingam, B, Louis, J.M, Harrison, R.W, Weber, I.T.
Deposit date:	2000-07-24
Release date:	2001-06-01
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes. Proteins, 43, 2001

1HTE

X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE
Descriptor:	(2R,4S)-2-[(R)-BENZYLCARBAMOYL-PHENYLACETYL-METHYL]-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, HIV-1 PROTEASE
Authors:	Jhoti, H, Wonacott, A, Murray-Rust, P.
Deposit date:	1994-04-29
Release date:	1994-07-31
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	X-ray crystallographic studies of a series of penicillin-derived asymmetric inhibitors of HIV-1 protease. Biochemistry, 33, 1994

1HII

COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR
Descriptor:	ACETYL-NH-VAL-CYCLOHEXYL-CH2[NCH2CHOH]CH2-BENZYL-VAL-NH-ACETYL, HIV-2 PROTEASE, SULFATE ION
Authors:	Priestle, J.P, Gruetter, M.G.
Deposit date:	1995-03-31
Release date:	1995-07-10
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor. Structure, 3, 1995

1HSI

CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
Descriptor:	HIV-2 PROTEASE
Authors:	Chen, Z.
Deposit date:	1995-03-31
Release date:	1996-04-03
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases. J.Biol.Chem., 269, 1994

1HSG

CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L-735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES
Descriptor:	HIV-1 PROTEASE, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE
Authors:	Chen, Z.
Deposit date:	1995-03-31
Release date:	1996-04-03
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases. J.Biol.Chem., 269, 1994

1HXB

HIV-1 proteinase complexed with RO 31-8959
Descriptor:	(2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, HIV-1 PROTEASE
Authors:	Graves, B.J, Hatada, M.H, Crowther, R.L.
Deposit date:	1996-09-13
Release date:	1997-03-12
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere. J.Med.Chem., 34, 1991

1HTF

X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE
Descriptor:	2-(BENZYLCARBAMOYL-PHENYLACETYLAMINO-METHYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID (HYDROXYMETHYL-2-PHENYLETHYL)AMIDE, HIV-1 PROTEASE
Authors:	Jhoti, H, Wonacott, A, Murray-Rust, P.
Deposit date:	1994-04-29
Release date:	1994-07-31
Last modified:	2024-06-12
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	X-ray crystallographic studies of a series of penicillin-derived asymmetric inhibitors of HIV-1 protease. Biochemistry, 33, 1994

1HXW

HIV-1 PROTEASE DIMER COMPLEXED WITH A-84538
Descriptor:	HIV-1 PROTEASE, RITONAVIR
Authors:	Park, C.H, Nienaber, V, Kong, X.P.
Deposit date:	1997-01-24
Release date:	1998-02-04
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc.Natl.Acad.Sci.USA, 92, 1995

1HPS

RATIONAL DESIGN, SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P1'-P2' AMIDE BOND ISOSTERE
Descriptor:	2-[(1R,3S,4S)-1-BENZYL-4-[N-(BENZYLOXYCARBONYL)-L-VALYL]AMINO-3-PHENYLPENTYL]-4(5)-(2-METHYLPROPIONYL)IMIDAZOLE, HIV-1 PROTEASE
Authors:	Abdel-Meguid, S, Zhao, B.
Deposit date:	1994-05-24
Release date:	1994-08-31
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Rational design, synthesis, and crystallographic analysis of a hydroxyethylene-based HIV-1 protease inhibitor containing a heterocyclic P1'--P2' amide bond isostere. J.Med.Chem., 37, 1994

1HIH

COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR
Descriptor:	ACETYL-NH-VAL-CYCLOHEXYL-CH2[NCH2CHOH]CH2-BENZYL-VAL-NH-ACETYL, BETA-MERCAPTOETHANOL, HIV-1 PROTEASE
Authors:	Priestle, J.P, Gruetter, M.G.
Deposit date:	1995-03-31
Release date:	1995-07-10
Last modified:	2018-04-18
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Comparative analysis of the X-ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor. Structure, 3, 1995

1HVH

NONPEPTIDE CYCLIC CYANOGUANIDINES AS HIV PROTEASE INHIBITORS
Descriptor:	HIV-1 PROTEASE, {[4-R(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS(4-HYDROXYMETHYL)METHYL]-4,7-BIS(PHENYLMETHYL) -2H-1,3-DIAZEPIN-2-YLIDENE]CYANAMIDE}
Authors:	Chang, C.-H.
Deposit date:	1997-12-13
Release date:	1998-12-30
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies. J.Med.Chem., 41, 1998

1HVC

CRYSTAL STRUCTURE OF A TETHERED DIMER OF HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR
Descriptor:	HIV-1 PROTEASE, N-{1-BENZYL-(2S,3S)-2,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:	Bhat, T.N, Baldwin, E.T, Erickson, J.W.
Deposit date:	1994-06-22
Release date:	1994-10-15
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Crystal structure of a tethered dimer of HIV-1 proteinase complexed with an inhibitor. Nat.Struct.Biol., 1, 1994

1HPO

HIV-1 PROTEASE TRIPLE MUTANT/U103265 COMPLEX
Descriptor:	4-CYANO-N-(3-CYCLOPROPYL(5,6,7,8,9,10-HEXAHYDRO-4-HYDROXY-2-OXO-CYCLOOCTA[B]PYRAN-3-YL)METHYL)PHENYL BENZENSULFONAMIDE, HIV-1 PROTEASE
Authors:	Watenpaugh, K.D, Janakiraman, M.N.
Deposit date:	1996-12-10
Release date:	1997-04-21
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Structure-based design of nonpeptidic HIV protease inhibitors: the sulfonamide-substituted cyclooctylpyramones. J.Med.Chem., 40, 1997

1IDB

Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere
Descriptor:	(2R,4S)-N-tert-butyl-1-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutyl]-4-(pyridin-4-ylsulfonyl)piperidine-2-carboxamide, Protease
Authors:	Tong, L, Anderson, P.C.
Deposit date:	1994-10-19
Release date:	1995-01-26
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere. Structure, 3, 1995

1FMB

EIAV PROTEASE COMPLEXED WITH THE INHIBITOR HBY-793
Descriptor:	EIAV PROTEASE, [2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYL-VALINYL]-PHENYLALANINOL
Authors:	Wlodawer, A, Gustchina, A, Zdanov, A, Kervinen, J.
Deposit date:	1996-02-27
Release date:	1996-10-14
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structure of equine infectious anemia virus proteinase complexed with an inhibitor. Protein Sci., 5, 1996

1FG8

STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES
Descriptor:	N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, PROTEASE RETROPEPSIN
Authors:	Mahalingam, B, Louis, J.M, Harrison, R.W, Weber, I.T.
Deposit date:	2000-07-25
Release date:	2001-06-01
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes. Proteins, 43, 2001

1FIV

STRUCTURE OF AN INHIBITOR COMPLEX OF PROTEINASE FROM FELINE IMMUNODEFICIENCY VIRUS
Descriptor:	FIV PROTEASE, FIV PROTEASE INHIBITOR ACE-ALN-VAL-STA-GLU-ALN-NH2
Authors:	Wlodawer, A, Gustchina, A, Reshetnikova, L, Lubkowski, J, Zdanov, A.
Deposit date:	1995-05-04
Release date:	1995-07-31
Last modified:	2019-08-14
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structure of an inhibitor complex of the proteinase from feline immunodeficiency virus. Nat.Struct.Biol., 2, 1995

1FQX

CRYSTAL STRUCTURE OF THE COMPLEX OF HIV-1 PROTEASE WITH A PEPTIDOMIMETIC INHIBITOR
Descriptor:	N-{(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide, PROTEASE RETROPEPSIN
Authors:	Dohnalek, J, Hasek, J, Duskova, J, Petrokova, H, Hradilek, M, Soucek, M, Konvalinka, J, Brynda, J, Sedlacek, J, Fabry, M.
Deposit date:	2000-09-07
Release date:	2001-03-14
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	A distinct binding mode of a hydroxyethylamine isostere inhibitor of HIV-1 protease. Acta Crystallogr.,Sect.D, 57, 2001

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Total results:	959
Displayed results:	25
Sorted by:	Hit score (from highest)
Query:	PF00077