2PQZ
HIV-1 Protease in complex with a pyrrolidine-based inhibitor
Summary for 2PQZ
| Entry DOI | 10.2210/pdb2pqz/pdb |
| Related | 1xl2 |
| Descriptor | Protease, CHLORIDE ION, N,N'-(3S,4S)-PYRROLIDINE-3,4-DIYLBIS(N-BENZYLBENZENESULFONAMIDE), ... (4 entities in total) |
| Functional Keywords | protein-ligand complex, hydrolase |
| Biological source | Human immunodeficiency virus 1 |
| Total number of polymer chains | 2 |
| Total formula weight | 22275.59 |
| Authors | Boettcher, J.,Blum, A.,Heine, A.,Diederich, W.E.,Klebe, G. (deposition date: 2007-05-03, release date: 2008-04-15, Last modification date: 2024-03-13) |
| Primary citation | Blum, A.,Bottcher, J.,Heine, A.,Klebe, G.,Diederich, W.E. Structure-Guided Design of C2-Symmetric HIV-1 Protease Inhibitors Based on a Pyrrolidine Scaffold. J.Med.Chem., 51:2078-2087, 2008 Cited by PubMed: 18348517DOI: 10.1021/jm701142s PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
Download full validation report
