2QCI

HIV-1 Protease mutant D30N with potent Antiviral inhibitor GRL-98065

Summary for 2QCI

Entry DOI	10.2210/pdb2qci/pdb
Related	2QD6 2QD7 2QD8 2Z4O
Descriptor	Protease, SODIUM ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	hiv-1, mutant d30n, protease inhibitor, hydrolase
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	2
Total formula weight	22208.98
Authors	Wang, Y.F.,Tie, Y.,Boross, P.I.,Tozser, J.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. (deposition date: 2007-06-19, release date: 2008-04-22, Last modification date: 2023-10-25)
Primary citation	Wang, Y.F.,Tie, Y.,Boross, P.I.,Tozser, J.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease. J.Med.Chem., 50:4509-4515, 2007 Cited by PubMed: 17696515 DOI: 10.1021/jm070482q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation