2Q3K

Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in HIV-1 Protease

Summary for 2Q3K

Entry DOI	10.2210/pdb2q3k/pdb
Descriptor	Protease, PHOSPHATE ION, ACETATE ION, ... (5 entities in total)
Functional Keywords	drug design, hiv-1 protease, protease inhibitors, viral protein
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22637.47
Authors	Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2007-05-30, release date: 2007-08-21, Last modification date: 2023-08-30)
Primary citation	Nalam, M.N.,Peeters, A.,Jonckers, T.H.,Dierynck, I.,Schiffer, C.A. Crystal structure of lysine sulfonamide inhibitor reveals the displacement of the conserved flap water molecule in human immunodeficiency virus type 1 protease. J.Virol., 81:9512-9518, 2007 Cited by PubMed: 17596316 DOI: 10.1128/JVI.00799-07 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation