2QD7

HIV-1 Protease Mutant V82A with potent Antiviral inhibitor GRL-98065

Summary for 2QD7

Entry DOI	10.2210/pdb2qd7/pdb
Related	2QCI 2QD6 2QD8 2Z4O
Descriptor	Protease, PHOSPHATE ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywords	hiv-1 protease mutant v82a, protease inhibitor, hydrolase
Biological source	Human immunodeficiency virus 1
Cellular location	Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
Total number of polymer chains	2
Total formula weight	22532.30
Authors	Wang, Y.F.,Tie, Y.,Boross, P.I.,Tozser, J.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. (deposition date: 2007-06-20, release date: 2008-04-22, Last modification date: 2023-10-25)
Primary citation	Wang, Y.F.,Tie, Y.,Boross, P.I.,Tozser, J.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease. J.Med.Chem., 50:4509-4515, 2007 Cited by PubMed: 17696515 DOI: 10.1021/jm070482q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.11 Å)

Structure validation