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2QI0

Crystal structure of protease inhibitor, MIT-1-KK80 in complex with wild type HIV-1 protease

Summary for 2QI0
Entry DOI10.2210/pdb2qi0/pdb
Related2QHY 2QHZ 2QI1 2QI3 2QI4 2QI5 2QI6 2QI7
DescriptorProtease, PHOSPHATE ION, N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[(3-METHOXYPHENYL)SULFONYL](2-THIENYLMETHYL)AMINO}PROPYL]-3-FLUORO-2-METHYLBENZAMIDE, ... (4 entities in total)
Functional Keywordsdrug design, hiv-1 protease, protease inhibitors, hydrolase
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22309.26
Authors
Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2007-07-03, release date: 2008-04-22, Last modification date: 2023-08-30)
Primary citationAltman, M.D.,Ali, A.,Reddy, G.S.,Nalam, M.N.,Anjum, S.G.,Cao, H.,Chellappan, S.,Kairys, V.,Fernandes, M.X.,Gilson, M.K.,Schiffer, C.A.,Rana, T.M.,Tidor, B.
HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.
J.Am.Chem.Soc., 130:6099-6113, 2008
Cited by
PubMed: 18412349
DOI: 10.1021/ja076558p
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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