2QHZ
Crystal structure of protease inhibitor, MIT-1-AC87 in complex with wild type HIV-1 protease
Summary for 2QHZ
Entry DOI | 10.2210/pdb2qhz/pdb |
Related | 2QHY 2QI0 2QI1 2QI3 2QI4 2QI5 2QI6 2QI7 |
Descriptor | Protease, PHOSPHATE ION, (2E)-N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{(2-THIENYLMETHYL)[(2,4,5-TRIFLUOROPHENYL)SULFONYL]AMINO}PROPYL]-4,4,4-TRIFLUORO-3-METHYLBUT-2-ENAMIDE, ... (4 entities in total) |
Functional Keywords | drug design, hiv-1 protease, protease inhibitors, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22713.03 |
Authors | Schiffer, C.A.,Nalam, M.N.L. (deposition date: 2007-07-03, release date: 2008-04-22, Last modification date: 2023-08-30) |
Primary citation | Altman, M.D.,Ali, A.,Reddy, G.S.,Nalam, M.N.,Anjum, S.G.,Cao, H.,Chellappan, S.,Kairys, V.,Fernandes, M.X.,Gilson, M.K.,Schiffer, C.A.,Rana, T.M.,Tidor, B. HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants. J.Am.Chem.Soc., 130:6099-6113, 2008 Cited by PubMed: 18412349DOI: 10.1021/ja076558p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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