PDB: 14265 resultsInfo pagesStatus searchChemie searchBIRD

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8ACP	RNA polymerase at U-rich pause bound to regulatory RNA putL - inactive, open clamp state Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Dey, S, Weixlbaumer, A. Deposit date: 2022-07-06 Release date: 2022-10-19 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Structural insights into RNA-mediated transcription regulation in bacteria. Mol.Cell, 82, 2022
8AC1	RNA polymerase at U-rich pause bound to non-regulatory RNA - inactive, open clamp state Descriptor: DNA Non-template strand, DNA Template strand, DNA-directed RNA polymerase subunit alpha, ... Authors: Dey, S, Weixlbaumer, A. Deposit date: 2022-07-05 Release date: 2022-10-26 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (4.06 Å) Cite: Structural insights into RNA-mediated transcription regulation in bacteria. Mol.Cell, 82, 2022
4PZ6	PCE1 guanylyltransferase bound to SER2/SER5 phosphorylated RNA pol II CTD Descriptor: DNA-directed RNA polymerase II subunit rpb1, GUANOSINE, mRNA-capping enzyme subunit alpha Authors: Doamekpor, S.K, Lima, C.D. Deposit date: 2014-03-28 Release date: 2014-06-25 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.406 Å) Cite: How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes. Genes Dev., 28, 2014
8POH	Influenza A/H7N9 polymerase symmetric dimer bound to the promoter (PA K289A/C489R) Descriptor: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-07-04 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8PNP	Influenza A/H7N9 polymerase in pre-initiation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A Descriptor: 51-mer vRNA loop (v51_mut_S), Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-06-30 Release date: 2024-02-21 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (2.49 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8PNQ	Influenza A/H7N9 polymerase in elongation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A Descriptor: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-06-30 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (2.88 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8PM0	Influenza A/H7N9 polymerase in replicase-like conformation in pre-initiation state with Pol II pS5 CTD peptide mimic bound in site 1A/2A Descriptor: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-06-27 Release date: 2024-02-21 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
6BZO	Mtb RNAP Holo/RbpA/Fidaxomicin/upstream fork DNA Descriptor: DNA (26-MER), DNA (32-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. Deposit date: 2017-12-25 Release date: 2018-03-28 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
6C06	Mycobacterium tuberculosis RNAP Holo/RbpA/Fidaxomicin Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M. Deposit date: 2017-12-27 Release date: 2018-03-28 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (5.15 Å) Cite: Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
6C04	Mtb RNAP Holo/RbpA/double fork DNA -closed clamp Descriptor: DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M. Deposit date: 2017-12-27 Release date: 2018-03-28 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.27 Å) Cite: Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
7Z0O	Structure of transcription factor UAF in complex with TBP and 35S rRNA promoter DNA Descriptor: Histone H3, Histone H4, Non-template DNA, ... Authors: Baudin, F, Murciano, B, Fung, H.K.H, Fromm, S.A, Mueller, C.W. Deposit date: 2022-02-23 Release date: 2022-04-27 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Mechanism of RNA polymerase I selection by transcription factor UAF. Sci Adv, 8, 2022
8R3L	Influenza A/H7N9 polymerase in pre-initiation state, intermediate conformation (I) with PB2-C(I), ENDO(T), and Pol II pS5 CTD peptide mimic bound in site 1A/2A Descriptor: 3' vRNA end (51-mer vRNA loop), Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-11-09 Release date: 2024-02-21 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8R3K	Influenza A/H7N9 polymerase in self-stalled pre-termination state, with Pol II pS5 CTD peptide mimic bound in site 1A/2A. Descriptor: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, PYROPHOSPHATE 2-, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-11-09 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
5K5M	Co-Crystal Structure of Dengue Virus Serotype 2 RNA Dependent RNA Polymerase with Compound 27 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, RNA Dependent RNA Polymerase, ... Authors: Arora, R, Benson, T.E. Deposit date: 2016-05-23 Release date: 2016-08-24 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling. Plos Pathog., 12, 2016
3P8B	X-ray crystal structure of Pyrococcus furiosus transcription elongation factor Spt4/5 Descriptor: BETA-MERCAPTOETHANOL, DNA-directed RNA polymerase, subunit e'', ... Authors: Murakami, K.S, Klein, B.J. Deposit date: 2010-10-13 Release date: 2011-01-26 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.8 Å) Cite: RNA polymerase and transcription elongation factor Spt4/5 complex structure. Proc.Natl.Acad.Sci.USA, 108, 2011
4K4W	Poliovirus polymerase elongation complex (r5+2_form) Descriptor: RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*AP*GP*AP*UP*GP*AP*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3'), RNA-directed RNA polymerase 3D-POL Authors: Gong, P, Peersen, O.B. Deposit date: 2013-04-12 Release date: 2013-05-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts. Plos One, 8, 2013
4K4U	Poliovirus polymerase elongation complex (r5_form) Descriptor: RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3'), RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*A)-3'), RNA (5'-R(P*GP*GP*GP*GP*GP*AP*GP*AP*UP*GP*A)-3'), ... Authors: Gong, P, Peersen, O.B. Deposit date: 2013-04-12 Release date: 2013-05-22 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts. Plos One, 8, 2013
3UGO	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TACAAT) Descriptor: 5'-D(*TP*GP*TP*AP*CP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.096 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
3UGP	Crystal structure of RNA-polymerase sigma subunit domain 2 complexed with -10 promoter element ssDNA oligo (TATAAT) Descriptor: 5'-D(*TP*GP*TP*AP*TP*AP*AP*TP*GP*GP*G)-3', POTASSIUM ION, RNA polymerase sigma factor Authors: Feklistov, A, Darst, S.A. Deposit date: 2011-11-02 Release date: 2011-12-07 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.697 Å) Cite: Structural basis for promoter-10 element recognition by the bacterial RNA polymerase sigma subunit. Cell(Cambridge,Mass.), 147, 2011
2WHO	CRYSTAL STRUCTURE OF HEPATITIS C VIRUS NS5B POLYMERASE FROM 1B GENOTYPE IN COMPLEX WITH A NON-NUCLEOSIDE INHIBITOR Descriptor: 2-(3-bromophenyl)-6-[(2-hydroxyethyl)amino]-1h-benzo[de]isoquinoline-1,3(2h)-dione, MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE Authors: Di Marco, S. Deposit date: 2009-05-05 Release date: 2009-08-11 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors. J. Med. Chem., 52, 2009
6BJS	CryoEM structure of E.coli his pause elongation complex without pause hairpin Descriptor: DNA (32-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Kang, J.Y, Landick, R, Darst, S.A. Deposit date: 2017-11-06 Release date: 2018-03-28 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (5.5 Å) Cite: RNA Polymerase Accommodates a Pause RNA Hairpin by Global Conformational Rearrangements that Prolong Pausing. Mol. Cell, 69, 2018
6CA0	Cryo-EM structure of E. coli RNAP sigma70 open complex Descriptor: DNA (35-MER), DNA (45-MER), DNA (5'-D(P*GP*CP*CP*GP*CP*GP*TP*CP*AP*GP*A)-3'), ... Authors: Narayanan, A, Vago, F, Li, K, Qayyum, M.Z, Yernool, D, Jiang, W, Murakami, K.S. Deposit date: 2018-01-29 Release date: 2018-02-28 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (5.75 Å) Cite: Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation. J. Biol. Chem., 293, 2018
6C9Y	Cryo-EM structure of E. coli RNAP sigma70 holoenzyme Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Narayanan, A, Vago, F, Li, K, Qayyum, M.Z, Yenool, D, Jiang, W, Murakami, K.S. Deposit date: 2018-01-29 Release date: 2018-02-28 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (4.25 Å) Cite: Cryo-EM structure ofEscherichia colisigma70RNA polymerase and promoter DNA complex revealed a role of sigma non-conserved region during the open complex formation. J. Biol. Chem., 293, 2018
5TJG	Thermus aquaticus delta1.1-sigmaA holoenzyme/downstream-fork promoter complex with an open clamp Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*A)-3'), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Darst, S.A, Bae, B. Deposit date: 2016-10-04 Release date: 2017-06-21 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.6 Å) Cite: RNA polymerase motions during promoter melting. Science, 356, 2017
5H0R	RNA dependent RNA polymerase ,vp4,dsRNA Descriptor: RNA (42-MER), RNA-dependent RNA polymerase, VP4 protein Authors: Li, X, Zhou, N, Chen, W, Zhu, B, Wang, X, Xu, B, Wang, J, Liu, H, Cheng, L. Deposit date: 2016-10-06 Release date: 2017-01-25 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Near-Atomic Resolution Structure Determination of a Cypovirus Capsid and Polymerase Complex Using Cryo-EM at 200kV J. Mol. Biol., 429, 2017

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