PDB: 3246 resultsInfo pagesStatus searchChemie searchBIRD

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7QVE	Spinach 20S proteasome Descriptor: Proteasome subunit alpha type, Proteasome subunit alpha type-3, Proteasome subunit beta, ... Authors: Kandolf, S, Grishkovskaya, I, Meinhart, A, Haselbach, D. Deposit date: 2022-01-21 Release date: 2022-05-25 Last modified: 2024-07-17 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Cryo-EM structure of the plant 26S proteasome. Plant Commun., 3, 2022
6ONY	BRD2_Bromodomain1 complex with inhibitor 744 Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 2, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide Authors: Longenecker, K.L, Bigelow, L. Deposit date: 2019-04-22 Release date: 2020-01-29 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer. Nature, 578, 2020
7KL1	Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Calcium/calmodulin-dependent protein kinase type II subunit alpha, ... Authors: Ozden, C, Stratton, M.M, Garman, S.C. Deposit date: 2020-10-28 Release date: 2020-12-23 Last modified: 2024-12-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: CaMKII binds both substrates and activators at the active site. Cell Rep, 40, 2022
7KMI	LY-CoV481 neutralizing antibody against SARS-CoV-2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, LY-CoV481 Fab heavy chain, ... Authors: Hendle, J, Pustilnik, A, Sauder, J.M, Coleman, K.A, Boyles, J.S, Dickinson, C.D. Deposit date: 2020-11-02 Release date: 2021-01-27 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.73 Å) Cite: The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates. Sci Transl Med, 13, 2021
7QVH	The crystal structure of HotPETase, an evolved thermostable variant of IsPETase Descriptor: Poly(ethylene terephthalate) hydrolase, TRIETHYLENE GLYCOL Authors: Hardy, F.J, Levy, C, Green, A.P. Deposit date: 2022-01-21 Release date: 2022-08-03 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Directed evolution of an efficient and thermostable PET depolymerase Nat Catal, 2022
5HGC	A Serpin structure Descriptor: (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranose, SULFATE ION, ... Authors: Das, S, Vashchenko, G.V, Van Petegem, F. Deposit date: 2016-01-08 Release date: 2016-04-06 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.43 Å) Cite: A Serpin structure J.Biol.Chem., 2016
1LCE	LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CH2THF Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5,10-METHYLENE-6-HYDROFOLIC ACID, THYMIDYLATE SYNTHASE Authors: Birdsall, D.L, Finer-Moore, J, Stroud, R.M. Deposit date: 1995-06-22 Release date: 1995-10-15 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
5JA4	Crystal structure of human TONSL and MCM2 HBDs binding to a histone H3-H4 tetramer Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA replication licensing factor MCM2, GLYCEROL, ... Authors: Huang, H, Patel, D. Deposit date: 2016-04-11 Release date: 2016-06-15 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.424 Å) Cite: H4K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex. Nature, 534, 2016
5JCG	Structure of Human Peroxiredoxin 3 as three stacked rings Descriptor: Thioredoxin-dependent peroxide reductase, mitochondrial Authors: Yewdall, N.A, Gerrard, J.A, Goldstone, D.C. Deposit date: 2016-04-15 Release date: 2016-05-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structures of Human Peroxiredoxin 3 Suggest Self-Chaperoning Assembly that Maintains Catalytic State. Structure, 24, 2016
7L3N	SARS-CoV 2 Spike Protein bound to LY-CoV555 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LY-CoV555 Fab heavy chain, ... Authors: Goldsmith, J.A, McLellan, J.S. Deposit date: 2020-12-18 Release date: 2021-02-03 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (3.27 Å) Cite: LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection. Biorxiv, 2020
8SU9	E. coli SIR2-HerA complex (hexamer HerA bound with dodecamer Sir2) Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside triphosphate hydrolase, ... Authors: Shen, Z.F, Lin, Q.P, Fu, T.M. Deposit date: 2023-05-11 Release date: 2024-03-27 Method: ELECTRON MICROSCOPY (2.83 Å) Cite: Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
8SUW	E. coli SIR2-HerA complex (dodecamer SIR2 bound 4 protomers of HerA) Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside triphosphate hydrolase, ... Authors: Shen, Z.F, Lin, Q.P, Fu, T.M. Deposit date: 2023-05-13 Release date: 2024-03-27 Method: ELECTRON MICROSCOPY (3.15 Å) Cite: Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
8SON	Crystal structure of macrophage migration inhibitory factor in complex with N-[3-(Trifluoromethyl)phenyl]-3-(2-chloroanilino)-2-cyano-3-thioxopropanamide Descriptor: (2R)-3-[(2-chlorophenyl)amino]-2-cyano-3-thioxo-N-[3-(trifluoromethyl)phenyl]propanamide, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2023-04-28 Release date: 2024-05-22 Last modified: 2025-06-04 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia. Acs Omega, 10, 2025
8SCW	Crystal structure of IRAK4-HSA complexed with BMS-986147; 6-{5-CYANO-1H-PYRAZOLO[3,4-B]PYRIDIN-1-YL}-N-[(2R)-2-FLUORROXY-3-METHYLBUTYL]-4-[(PROPAN-2-YL)AMINO]PYRIDINE-3-CARBOXAMIDE Descriptor: (6M)-6-(5-cyano-1H-pyrazolo[3,4-b]pyridin-1-yl)-N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide, Interleukin-1 receptor-associated kinase 4, SULFATE ION Authors: Muckelbauer, J.K, Ghosh, K. Deposit date: 2023-04-05 Release date: 2025-02-12 Method: X-RAY DIFFRACTION (2.76 Å) Cite: The Discovery of IRAK4 Inhibitor Clinical Candidates BMS-986126 and BMS-986147 for the Treatment of Autoimmune Diseases To Be Published
8SCE	Crystal structure of IRAK4-HSA complexed with N-[(2R)-2-FLUORO-3-HYDROXY-3-METHYLBUTYL]-6-[(5-FLUOROPYRI-YL)AMINO]-4-[(PROPAN-2-YL)AMINO]PYRIDINE-3-CARBOXAMIDE Descriptor: Interleukin-1 receptor-associated kinase 4, N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-6-[(5-fluoropyrimidin-4-yl)amino]-4-[(propan-2-yl)amino]pyridine-3-carboxamide, SULFATE ION Authors: Muckelbauer, J.K, Ghosh, K. Deposit date: 2023-04-05 Release date: 2025-02-12 Method: X-RAY DIFFRACTION (1.89 Å) Cite: The Discovery of IRAK4 Inhibitor Clinical Candidates BMS-986126 and BMS-986147 for the Treatment of Autoimmune Diseases To Be Published
8SCV	Crystal structure of IRAK4-HSA complexed with BMS-986126; 6-((5-CYANO-2-PYRIMIDINYL)AMINO)-N-((2R)-2-FLUORO-3-HYDROXHYLBUTYL)-4-(ISOPROPYLAMINO)NICOTINAMIDE Descriptor: 6-[(5-cyanopyrimidin-2-yl)amino]-N-[(2R)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide, Interleukin-1 receptor-associated kinase 4, SULFATE ION Authors: Muckelbauer, J.K, Ghosh, K. Deposit date: 2023-04-05 Release date: 2025-02-12 Method: X-RAY DIFFRACTION (2.69 Å) Cite: The Discovery of IRAK4 Inhibitor Clinical Candidates BMS-986126 and BMS-986147 for the Treatment of Autoimmune Diseases To Be Published
8TNF	Crystal structure of sulfohexulose-1-phosphate aldolase from Paracoccus onubensis strain Merri Descriptor: DUF2090 domain-containing protein Authors: Lee, M. Deposit date: 2023-08-01 Release date: 2024-08-07 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A patchwork pathway for catabolism degradation of the sulfosugar sulfofucose To Be Published
8SXX	E. coli dodecamer SIR2 Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SIR2-like domain-containing protein Authors: Shen, Z.F, Lin, Q.P, Fu, T.M. Deposit date: 2023-05-24 Release date: 2023-12-27 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
8SUB	E. coli SIR2-HerA complex (dodecamer SIR2 pentamer HerA) Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Nucleoside triphosphate hydrolase, ... Authors: Shen, Z.F, Lin, Q.P, Fu, T.M. Deposit date: 2023-05-11 Release date: 2023-12-27 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (2.89 Å) Cite: Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
8UAE	E. coli Sir2_HerA complex (12:6) with ATPgamaS Descriptor: MAGNESIUM ION, Nucleoside triphosphate hydrolase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... Authors: Shen, Z.F, Lin, Q.P, Fu, T.M. Deposit date: 2023-09-20 Release date: 2023-12-27 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
8UAF	E. coli Sir2_HerA complex (12:6) bound with NAD+ Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Shen, Z.F, Lin, Q.P, Fu, T.M. Deposit date: 2023-09-20 Release date: 2023-12-27 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Assembly-mediated activation of the SIR2-HerA supramolecular complex for anti-phage defense. Mol.Cell, 83, 2023
2H6V	Spectroscopic and structural study of the heterotropic linkage between halide and proton ion binding to GFP proteins- E2(GFP) APO FORM Descriptor: Green fluorescent protein, SODIUM ION Authors: Garau, G. Deposit date: 2006-06-01 Release date: 2007-05-15 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Spectroscopic and Structural Study of Proton and Halide Ion Cooperative Binding to GFP Biophys.J., 93, 2007
1THY	REFINED STRUCTURES OF SUBSTRATE-BOUND AND PHOSPHATE-BOUND THYMIDYLATE SYNTHASE FROM LACTOBACILLUS CASEI Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE Authors: Finer-Moore, J, Stroud, R. Deposit date: 1993-04-02 Release date: 1993-10-31 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
2I7Z	GAAA tetraloop receptor complex with associated manganese ions. Descriptor: 43-MER, MANGANESE (II) ION Authors: Davis, J.H, Butcher, S.E. Deposit date: 2006-08-31 Release date: 2007-04-03 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Role of metal ions in the tetraloop-receptor complex as analyzed by NMR. Rna, 13, 2007
6RVO	Multicrystal dataset of thaumatin collected using a multilayer monochromator. Descriptor: L(+)-TARTARIC ACID, Thaumatin I Authors: Sandy, J, Sanchez-Weatherby, J, Mikolajek, H, Winter, G. Deposit date: 2019-05-31 Release date: 2019-06-19 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Protein-to-structure pipeline for ambient-temperature crystallography at VMXi Iucrj, 2023

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