5JA4

Crystal structure of human TONSL and MCM2 HBDs binding to a histone H3-H4 tetramer

Summary for 5JA4

• Entry DOI: 10.2210/pdb5ja4/pdb
• Descriptor: Histone H3.3, Histone H4, DNA replication licensing factor MCM2, ... (7 entities in total)
• Functional Keywords: dna repair and histone chaperone, chaperone
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: P84243 P62805 P49736; Cytoplasm: Q96HA7
• Total number of polymer chains: 4
• Total formula weight: 48897.54

Authors

Huang, H.,Patel, D. (deposition date: 2016-04-11, release date: 2016-06-15, Last modification date: 2023-09-27)

• Primary citation: Saredi, G.,Huang, H.,Hammond, C.M.,Alabert, C.,Bekker-Jensen, S.,Forne, I.,Reveron-Gomez, N.,Foster, B.M.,Mlejnkova, L.,Bartke, T.,Cejka, P.,Mailand, N.,Imhof, A.,Patel, D.J.,Groth, A.; H4K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex.; Nature, 534:714-718, 2016; PubMed: 27338793; DOI: 10.1038/nature18312

Experimental method

X-RAY DIFFRACTION (2.424 Å)