6ONY

BRD2_Bromodomain1 complex with inhibitor 744

Summary for 6ONY

• Entry DOI: 10.2210/pdb6ony/pdb
• Descriptor: Bromodomain-containing protein 2, 1,2-ETHANEDIOL, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide, ... (4 entities in total)
• Functional Keywords: brd2, inhibitor, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 30877.92

Authors

Longenecker, K.L.,Bigelow, L. (deposition date: 2019-04-22, release date: 2020-01-29, Last modification date: 2024-03-13)

• Primary citation: Faivre, E.J.,McDaniel, K.F.,Albert, D.H.,Mantena, S.R.,Plotnik, J.P.,Wilcox, D.,Zhang, L.,Bui, M.H.,Sheppard, G.S.,Wang, L.,Sehgal, V.,Lin, X.,Huang, X.,Lu, X.,Uziel, T.,Hessler, P.,Lam, L.T.,Bellin, R.J.,Mehta, G.,Fidanze, S.,Pratt, J.K.,Liu, D.,Hasvold, L.A.,Sun, C.,Panchal, S.C.,Nicolette, J.J.,Fossey, S.L.,Park, C.H.,Longenecker, K.,Bigelow, L.,Torrent, M.,Rosenberg, S.H.,Kati, W.M.,Shen, Y.; Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.; Nature, 578:306-310, 2020; PubMed: 31969702; DOI: 10.1038/s41586-020-1930-8

Experimental method

X-RAY DIFFRACTION (1.98 Å)