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8B1W
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NDM-1 metallo-beta-lactamase in complex with triazole-based inhibitor CP35
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[(~{E})-(3-bromophenyl)methylideneamino]-5-(trifluoromethyl)-1,2,4-triazole-3-thiol, ...
Authors:Vascon, F, Lazzarato, L, Bersani, M, Gianquinto, E, Docquier, J.D, Spyrakis, F, Tondi, D, Cendron, L.
Deposit date:2022-09-12
Release date:2023-12-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure-Based Optimization of 1,2,4-Triazole-3-Thione Derivatives: Improving Inhibition of NDM-/VIM-Type Metallo-beta-Lactamases and Synergistic Activity on Resistant Bacteria.
Pharmaceuticals, 16, 2023
6XBF
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BU of 6xbf by Molmil
Structure of NDM-1 in complex with macrocycle inhibitor NDM1i-1G
Descriptor: BlaNDM-4_1_JQ348841, ZINC ION, macrocycle inhibitor NDM1i-1G
Authors:Worrall, L.J, Sun, T, Mulligan, V.K, Strynadka, N.C.J.
Deposit date:2020-06-05
Release date:2021-03-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Computationally designed peptide macrocycle inhibitors of New Delhi metallo-beta-lactamase 1.
Proc.Natl.Acad.Sci.USA, 118, 2021
6XBE
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Structure of NDM-1 in complex with macrocycle inhibitor NDM1i-1F
Descriptor: BlaNDM-4_1_JQ348841, ZINC ION, macrocycle inhibitor NDM1i-1F
Authors:Worrall, L.J, Sun, T, Mulligan, V.K, Strynadka, N.C.J.
Deposit date:2020-06-05
Release date:2021-03-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Computationally designed peptide macrocycle inhibitors of New Delhi metallo-beta-lactamase 1.
Proc.Natl.Acad.Sci.USA, 118, 2021
6XCI
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BU of 6xci by Molmil
Structure of NDM-1 in complex with macrocycle inhibitor NDM1i-3D
Descriptor: ACETATE ION, BlaNDM-4_1_JQ348841, CADMIUM ION, ...
Authors:Worrall, L.J, Sun, T, Mulligan, V.K, Strynadka, N.C.J.
Deposit date:2020-06-08
Release date:2021-03-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Computationally designed peptide macrocycle inhibitors of New Delhi metallo-beta-lactamase 1.
Proc.Natl.Acad.Sci.USA, 118, 2021
8D2Z
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BU of 8d2z by Molmil
Crystal Structure of a Metallo-beta-lactamase superfamily protein from Burkholderia cenocepacia
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ...
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-05-31
Release date:2023-07-05
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of a Metallo-beta-lactamase superfamily protein from Burkholderia cenocepacia
to be published
6XFR
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BU of 6xfr by Molmil
Metallo-beta-lactamase from Pontibacter korlensis
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Lactamase_B domain-containing protein, SODIUM ION, ...
Authors:Schenk, G, Schembri, M.A, Prombhul, S.
Deposit date:2020-06-16
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.608 Å)
Cite:Metallo-beta-lactamase from Pontibacter korlensis
To Be Published
7PP0
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BU of 7pp0 by Molmil
Crystal structure of the VIM-2 acquired metallo-beta-Lactamase in complex with compound 28 (JMV-7038)
Descriptor: 2-[2-[3-[3-(2-morpholin-4-ylethoxy)phenyl]-5-sulfanylidene-1H-1,2,4-triazol-4-yl]ethyl]benzoic acid, ACETATE ION, Metallo-beta-lactamase VIM-2-like protein, ...
Authors:Tassone, G, Benvenuti, M, Verdirosa, F, Corsica, G, Chelini, G, De Luca, F, Docquier, J.D, Pozzi, C, Mangani, S.
Deposit date:2021-09-10
Release date:2022-03-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-beta-Lactamase Inhibitors.
Chemmedchem, 17, 2022
6YRP
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BU of 6yrp by Molmil
Crystal Structure of the VIM-2 Acquired Metallo-beta-Lactamase in Complex with JMV-4690 (Cpd 31)
Descriptor: 1,2-ETHANEDIOL, 2-[[[3-(5-methoxy-2-oxidanyl-phenyl)-5-sulfanylidene-1~{H}-1,2,4-triazol-4-yl]amino]methyl]benzoic acid, ACETATE ION, ...
Authors:Docquier, J.D, Pozzi, C, De Luca, F, Benvenuti, M, Mangani, S.
Deposit date:2020-04-20
Release date:2020-09-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-beta-lactamase inhibitors.
Eur.J.Med.Chem., 208, 2020
4WD6
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BU of 4wd6 by Molmil
Crystal Structure of DIM-1 metallo-beta-lactamase
Descriptor: Metallo-beta-lactamase, ZINC ION
Authors:Booth, M.P.S, Kosmopoulou, M, Spencer, J.
Deposit date:2014-09-07
Release date:2014-09-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of DIM-1 metallo-beta-lactamase
To Be Published
4UWS
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BU of 4uws by Molmil
VIM-26-PEG. Leu224 in VIM-26 from Klebsiella pneumoniae has implications for drug binding.
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, METALLO-BETA-LACTAMASE VIM-26, ...
Authors:Leiros, H.-K.S, Edvardsen, K.S.W, Bjerga, G.E.K, Samuelsen, O.
Deposit date:2014-08-14
Release date:2015-02-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural and Biochemical Characterization of Vim-26 Show that Leu224 Has Implications for the Substrate Specificity of Vim Metallo-Beta-Lactamases.
FEBS J., 282, 2015
4HKY
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BU of 4hky by Molmil
New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Faropenem
Descriptor: (2R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-5-[(2R)-oxolan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid, (5R,6S)-6-(1-hydroxyethyl)-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, Beta-lactamase NDM-1, ...
Authors:Kim, Y, Tesar, C, Jedrzejczak, R, Babnigg, J, Mire, J, Sacchettini, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Structures of Mtb Proteins Conferring Susceptibility to Known Mtb Inhibitors (MTBI)
Deposit date:2012-10-15
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Faropenem
To be Published
8R5U
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BU of 8r5u by Molmil
VIM-2 metallo-beta-lactamase in complex with benzebisheterocycle compound 14
Descriptor: Beta-lactamase VIM-2, FORMIC ACID, ZINC ION, ...
Authors:Hinchliffe, P, Spencer, J.
Deposit date:2023-11-17
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Rational Design of Benzobisheterocycle Metallo-beta-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.
J.Med.Chem., 67, 2024
8R5T
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BU of 8r5t by Molmil
Crystal structure of NDM-1 in complex with benzobisheterocycle compound 14.
Descriptor: Metallo-beta-lactamase type 2, SULFATE ION, ZINC ION, ...
Authors:Hinchliffe, P, Spencer, J.
Deposit date:2023-11-17
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Rational Design of Benzobisheterocycle Metallo-beta-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.
J.Med.Chem., 67, 2024
4UWO
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BU of 4uwo by Molmil
Native di-zinc VIM-26. Leu224 in VIM-26 from Klebsiella pneumoniae has implications for drug binding.
Descriptor: GLYCEROL, METALLO-BETA-LACTAMASE VIM-26, SODIUM ION, ...
Authors:Leiros, H.-K.S, Edvardsen, K.S.W, Bjerga, G.E.K, Samuelsen, O.
Deposit date:2014-08-14
Release date:2015-02-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.555 Å)
Cite:Structural and Biochemical Characterization of Vim-26 Show that Leu224 Has Implications for the Substrate Specificity of Vim Metallo-Beta-Lactamases.
FEBS J., 282, 2015
4UWR
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BU of 4uwr by Molmil
Mono-zinc VIM-26. Leu224 in VIM-26 from Klebsiella pneumoniae has implications for drug binding.
Descriptor: FORMIC ACID, METALLO-BETA-LACTAMASE VIM-26, SODIUM ION, ...
Authors:Leiros, H.-K.S, Edvardsen, K.S.W, Bjerga, G.E.K, Samuelsen, O.
Deposit date:2014-08-14
Release date:2015-02-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural and Biochemical Characterization of Vim-26 Show that Leu224 Has Implications for the Substrate Specificity of Vim Metallo-Beta-Lactamases.
FEBS J., 282, 2015
8HXW
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BU of 8hxw by Molmil
Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-heptylthiazole-4-carboxylic acid
Descriptor: 2-azanyl-5-heptyl-1,3-thiazole-4-carboxylic acid, Beta-lactamase class B VIM-2, FORMIC ACID, ...
Authors:Yan, Y.-H, Zhu, K.-R, Li, G.-B.
Deposit date:2023-01-05
Release date:2023-11-01
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.
J.Med.Chem., 66, 2023
8HY6
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BU of 8hy6 by Molmil
Crystal structure of B1 NDM-1 MBL in complex with 2-amino-5-phenethylthiazole-4-carboxylic acid
Descriptor: 2-azanyl-5-(2-phenylethyl)-1,3-thiazole-4-carboxylic acid, GLYCEROL, Metallo-beta-lactamase type 2, ...
Authors:Yan, Y.-H, Zhu, K.-R, Li, G.-B.
Deposit date:2023-01-05
Release date:2023-11-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.
J.Med.Chem., 66, 2023
8HY2
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BU of 8hy2 by Molmil
Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-phenethylthiazole-4-carboxylic acid
Descriptor: 2-azanyl-5-(2-phenylethyl)-1,3-thiazole-4-carboxylic acid, Beta-lactamase class B VIM-2, FORMIC ACID, ...
Authors:Yan, Y.-H, Zhu, K.-R, Li, G.-B.
Deposit date:2023-01-05
Release date:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.
J.Med.Chem., 66, 2023
8HY1
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BU of 8hy1 by Molmil
Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-(thiophen-2-ylmethyl)thiazole-4-carboxylic acid
Descriptor: 2-azanyl-5-(thiophen-2-ylmethyl)-1,3-thiazole-4-carboxylic acid, Beta-lactamase class B VIM-2, ZINC ION
Authors:Yan, Y.-H, Zhu, K.-R, Li, G.-B.
Deposit date:2023-01-05
Release date:2023-11-01
Method:X-RAY DIFFRACTION (1.937 Å)
Cite:Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.
J.Med.Chem., 66, 2023
8HYD
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BU of 8hyd by Molmil
Crystal structure of B1 VIM-2 MBL in complex with 2-amino-5-(2-(thiophen-2-yl)ethyl)thiazole-4-carboxylic acid
Descriptor: 2-azanyl-5-(2-thiophen-2-ylethyl)-1,3-thiazole-4-carboxylic acid, Beta-lactamase class B VIM-2, ZINC ION
Authors:Yan, Y.-H, Zhu, K.-R, Li, G.-B.
Deposit date:2023-01-06
Release date:2023-11-01
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-beta-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding.
J.Med.Chem., 66, 2023
8SKP
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BU of 8skp by Molmil
X-ray structure of the NDM-4 beta-lactamase from Klebsiella pneumonia in complex with 1-hydroxypyridine-2(1H)-thione-6-carboxylic acid
Descriptor: 1,2-ETHANEDIOL, 1-hydroxy-6-sulfanylidene-1,6-dihydropyridine-2-carboxylic acid, Metallo-beta-lactamase type 2, ...
Authors:Thoden, J.B, Holden, H.M.
Deposit date:2023-04-20
Release date:2023-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Characterization of a novel inhibitor for the New Delhi metallo-beta-lactamase-4: Implications for drug design and combating bacterial drug resistance.
J.Biol.Chem., 299, 2023
8SKO
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BU of 8sko by Molmil
X-ray structure of the NDM-4 beta-lactamase from Klebsiella pneumonia with L-Captopril bound
Descriptor: L-CAPTOPRIL, Metallo-beta-lactamase type 2, ZINC ION
Authors:Thoden, J.B, Holden, H.M.
Deposit date:2023-04-20
Release date:2023-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Characterization of a novel inhibitor for the New Delhi metallo-beta-lactamase-4: Implications for drug design and combating bacterial drug resistance.
J.Biol.Chem., 299, 2023
8SK2
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BU of 8sk2 by Molmil
X-ray structure of the NDM-4 beta-lactamase from Klebsiella pneumonia, apo form
Descriptor: 1,2-ETHANEDIOL, Metallo-beta-lactamase type 2, ZINC ION
Authors:Thoden, J.B, Holden, H.M.
Deposit date:2023-04-18
Release date:2023-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Characterization of a novel inhibitor for the New Delhi metallo-beta-lactamase-4: Implications for drug design and combating bacterial drug resistance.
J.Biol.Chem., 299, 2023
8I52
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BU of 8i52 by Molmil
Crystal structure of VIM-2 metallo-beta-lactamase in complex with 10-HHIA
Descriptor: (2~{S})-2-butyl-3-methylidene-butanedioic acid, Beta-lactamase class B VIM-2, FORMIC ACID, ...
Authors:Wachino, J.
Deposit date:2023-01-23
Release date:2024-01-10
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Crystal structure of VIM-2 Metallo-beta-lactamase in complex with 10-HHIA
To Be Published
8U00
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BU of 8u00 by Molmil
Crystal structure of metallo-beta-lactamase superfamily protein from Caulobacter vibrioides
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Kim, Y, Maltseva, N, Endres, M, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2023-08-28
Release date:2023-09-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of metallo-beta-lactamase superfamily protein from Caulobacter vibrioides
To Be Published

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PDB entries from 2024-06-19

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