7OVE

Crystal structure of the VIM-2 acquired metallo-beta-Lactamase in Complex with compound 10 (JMV-7210)

Summary for 7OVE

Entry DOI	10.2210/pdb7ove/pdb
Descriptor	Metallo-beta-lactamase VIM-2-like protein, ZINC ION, ACETATE ION, ... (5 entities in total)
Functional Keywords	metallo-beta-lactamase, vim-2, triazole-thione, inhibitor, zinc, hydrolase
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	1
Total formula weight	25853.64
Authors	Tassone, G.,Benvenuti, M.,Verdirosa, F.,Sannio, F.,Mangani, S.,Docquier, J.D.,Pozzi, C.,Marcoccia, F. (deposition date: 2021-06-14, release date: 2021-10-20, Last modification date: 2024-01-31)
Primary citation	Legru, A.,Verdirosa, F.,Hernandez, J.F.,Tassone, G.,Sannio, F.,Benvenuti, M.,Conde, P.A.,Bossis, G.,Thomas, C.A.,Crowder, M.W.,Dillenberger, M.,Becker, K.,Pozzi, C.,Mangani, S.,Docquier, J.D.,Gavara, L. 1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-beta-lactamase inhibitors with re-sensitization activity. Eur.J.Med.Chem., 226:113873-113873, 2021 Cited by PubMed: 34626878 DOI: 10.1016/j.ejmech.2021.113873 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation