1DD6

IMP-1 METALLO BETA-LACTAMASE FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH A MERCAPTOCARBOXYLATE INHIBITOR

Summary for 1DD6

• Entry DOI: 10.2210/pdb1dd6/pdb
• Related: 1DDK
• Descriptor: IMP-1 METALLO BETA-LACTAMASE, SULFATE ION, ZINC ION, ... (5 entities in total)
• Functional Keywords: metallo beta-lactamase inhibitor, mercaptocarboxylate inhibitor, imp-1 metallo beta-lactamase, hydrolase
• Biological source: Pseudomonas aeruginosa
• Cellular location: Periplasm : P52699
• Total number of polymer chains: 2
• Total formula weight: 51510.08

Authors

Concha, N.O.,Janson, C.A.,Rowling, P.,Pearson, S.,Cheever, C.A.,Clarke, B.P.,Lewis, C.,Galleni, M.,Frere, J.M.,Payne, D.J.,Bateson, J.H.,Abdel-Meguid, S.S. (deposition date: 1999-11-08, release date: 2000-11-08, Last modification date: 2024-02-07)

• Primary citation: Concha, N.O.,Janson, C.A.,Rowling, P.,Pearson, S.,Cheever, C.A.,Clarke, B.P.,Lewis, C.,Galleni, M.,Frere, J.M.,Payne, D.J.,Bateson, J.H.,Abdel-Meguid, S.S.; Crystal structure of the IMP-1 metallo beta-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: binding determinants of a potent, broad-spectrum inhibitor.; Biochemistry, 39:4288-4298, 2000; PubMed: 10757977; DOI: 10.1021/bi992569m

Experimental method

X-RAY DIFFRACTION (2 Å)