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4P0L	Crystal Structure of Double Loop-Swapped Interleukin-36Ra With Additional Point Mutations Descriptor: Interleukin-36 receptor antagonist/Interleukin-36 gamma chimera protein Authors: Guenther, S, Sundberg, E.J. Deposit date: 2014-02-21 Release date: 2014-06-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J Immunol., 193, 2014
4R6U	IL-18 receptor complex Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-18, Interleukin-18 receptor 1 Authors: Wei, H, Wang, X. Deposit date: 2014-08-26 Release date: 2014-10-15 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis for the specific recognition of IL-18 by its alpha receptor. Febs Lett., 588, 2014
4X37	Gallus interleukin-1 mutant - E118K Descriptor: IL-1 beta Authors: Yin, H.S, Cheng, W.T, Cheng, T. Deposit date: 2014-11-28 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Gallus interleukin-1 mutant - E118K To Be Published
4X38	Gallus interleukin-1 beta mutant - E118A Descriptor: IL-1 beta Authors: Yin, H.S, Cheng, W.T. Deposit date: 2014-11-28 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Gallus interleukin-1 beta mutant - E118A To Be Published
4X39	Gallus interleukin-1 beta mutant - T117A Descriptor: IL-1 beta Authors: Yin, H.S, Cheng, W.T. Deposit date: 2014-11-28 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Gallus interleukin-1 beta mutant - T117A To Be Published
4X3A	gallus interleukin-1 beta mutant - R140A Descriptor: IL-1 beta Authors: Yin, H.S, Cheng, W.T. Deposit date: 2014-11-28 Release date: 2015-12-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.75 Å) Cite: gallus interleukin-1 beta mutant - R140A To Be Published
4XFS	Structure of IL-18 SER Mutant I Descriptor: DIMETHYL SULFOXIDE, GLYCEROL, Interleukin-18 Authors: Krumm, B.E, Meng, X, Xiang, Y, Deng, J. Deposit date: 2014-12-28 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
4XFT	Structure of IL-18 SER Mutant III Descriptor: DIMETHYL SULFOXIDE, Interleukin-18 Authors: Krumm, B.E, Meng, X, Xiang, Y, Deng, J. Deposit date: 2014-12-29 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
4XFU	Structure of IL-18 SER Mutant V Descriptor: Interleukin-18 Authors: Krumm, B.E, Meng, X, Xiang, Y, Deng, J. Deposit date: 2014-12-29 Release date: 2015-06-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Crystallization of interleukin-18 for structure-based inhibitor design. Acta Crystallogr.,Sect.F, 71, 2015
5BOW	CRYSTAL STRUCTURE OF IL-38 Descriptor: 1,2-ETHANEDIOL, Interleukin-1 family member 10 Authors: Guenther, S, Sundberg, E.J. Deposit date: 2015-05-27 Release date: 2016-06-01 Last modified: 2017-11-22 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Crystal Structure of Interleukin-38 To Be Published
5BVP	The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1beta Descriptor: CHLORIDE ION, Canakinumab Fab light-chain, Interleukin-1 beta, ... Authors: Rondeau, J.M. Deposit date: 2015-06-05 Release date: 2015-09-02 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1 beta. Mabs, 7, 2015
5HN1	Crystal structure of Interleukin-37 Descriptor: Interleukin-37, SULFATE ION Authors: Ellisdon, A.M, Nold-Petry, C.A, Nold, M.F, Whisstock, J.C. Deposit date: 2016-01-17 Release date: 2017-02-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Homodimerization attenuates the anti-inflammatory activity of interleukin-37. Sci Immunol, 2, 2017
5I1B	A COMPARISON OF THE HIGH RESOLUTION STRUCTURES OF HUMAN AND MURINE INTERLEUKIN-1B Descriptor: INTERLEUKIN-1 BETA Authors: Ohlendorf, D.H, Salemme, F.R. Deposit date: 1990-09-07 Release date: 1992-01-15 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A Comparison of the High Resolution Structures of Human and Murine Interleukin-1B To be Published
5MVZ	Fab 4AB007 bound to Interleukin-1-beta Descriptor: Fab 4AB007 H-chain, Fab 4AB007 L-chain, GLYCEROL, ... Authors: Stark, W, Seibert, V. Deposit date: 2017-01-17 Release date: 2017-02-15 Last modified: 2019-02-20 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structure of a novel, fully Human Fab binding to Interleukin 1-beta. To Be Published
5R7W	PanDDA analysis group deposition of ground-state model of INTERLEUKIN-1 BETA Descriptor: Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-02 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.27 Å) Cite: PanDDA analysis group deposition of ground-state model To Be Published
5R85	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z1262246195 in complex with INTERLEUKIN-1 BETA Descriptor: 3,3,3-tris(fluoranyl)-1-piperazin-1-yl-propan-1-one, Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.44 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R86	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z943693514 in complex with INTERLEUKIN-1 BETA Descriptor: Interleukin-1 beta, SULFATE ION, ~{N}-(4-hydroxyphenyl)-2-methoxy-ethanamide Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R87	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z44592329 in complex with INTERLEUKIN-1 BETA Descriptor: Interleukin-1 beta, N-phenyl-N'-pyridin-3-ylurea, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R88	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z1545313172 in complex with INTERLEUKIN-1 BETA Descriptor: (2~{S})-~{N}-(4-aminocarbonylphenyl)oxolane-2-carboxamide, Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.48 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R89	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z217038356 in complex with INTERLEUKIN-1 BETA Descriptor: 1-[(2~{S})-2-methylmorpholin-4-yl]-2-pyrazol-1-yl-ethanone, Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R8A	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z1492796719 in complex with INTERLEUKIN-1 BETA Descriptor: Interleukin-1 beta, SULFATE ION, ~{N}-[(3~{R})-1,2,3,4-tetrahydroquinolin-3-yl]ethanamide Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R8B	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z2027049478 in complex with INTERLEUKIN-1 BETA Descriptor: 5-(1,3-thiazol-2-yl)-1H-1,2,4-triazole, Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R8C	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z30857828 in complex with INTERLEUKIN-1 BETA Descriptor: Interleukin-1 beta, N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R8D	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z1745658474 in complex with INTERLEUKIN-1 BETA Descriptor: 2-(trifluoromethyl)pyrimidine-5-carboxamide, Interleukin-1 beta, SULFATE ION Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020
5R8E	PanDDA analysis group deposition INTERLEUKIN-1 BETA -- Fragment Z57475877 in complex with INTERLEUKIN-1 BETA Descriptor: Interleukin-1 beta, SULFATE ION, ~{N}-(2-ethyl-1,2,3,4-tetrazol-5-yl)butanamide Authors: De Nicola, G.F, Nichols, C.E. Deposit date: 2020-03-03 Release date: 2020-04-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Mining the PDB for Tractable Cases Where X-ray Crystallography Combined with Fragment Screens Can Be Used to Systematically Design Protein-Protein Inhibitors: Two Test Cases Illustrated by IL1 beta-IL1R and p38 alpha-TAB1 Complexes. J.Med.Chem., 63, 2020

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