2CJA
 
 | | Crystal structure of Methanosarcina barkeri seryl-tRNA synthetase complexed with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ... | | Authors: | Bilokapic, S, Maier, T, Ahel, D, Gruic-Sovulj, I, Soll, D, Weygand-Durasevic, I, Ban, N. | | Deposit date: | 2006-03-30 | | Release date: | 2006-06-26 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of the Unusual Seryl-tRNA Synthetase Reveals a Distinct Zinc-Dependent Mode of Substrate Recognition
Embo J., 25, 2006
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2CIM
 | | Crystal structure of Methanosarcina barkeri seryl-tRNA synthetase | | Descriptor: | CHLORIDE ION, PLATINUM (II) ION, SERYL-TRNA SYNTHETASE, ... | | Authors: | Bilokapic, S, Maier, T, Ahel, D, Gruic-Sovulj, I, Soll, D, Weygand-Durasevic, I, Ban, N. | | Deposit date: | 2006-03-24 | | Release date: | 2006-06-26 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Structure of the Unusual Seryl-tRNA Synthetase Reveals a Distinct Zinc-Dependent Mode of Substrate Recognition
Embo J., 25, 2006
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2CXA
 | | Crystal structure of Leucyl/phenylalanyl-tRNA protein transferase from Escherichia coli | | Descriptor: | Leucyl/phenylalanyl-tRNA-protein transferase | | Authors: | Kato-Murayama, M, Bessho, Y, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | Deposit date: | 2005-06-28 | | Release date: | 2005-12-28 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The crystal structure of leucyl/phenylalanyl-tRNA-protein transferase from Escherichia coli
Protein Sci., 16, 2007
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3KFL
 | | Leishmania major methionyl-tRNA synthetase in complex with methionyladenylate and pyrophosphate | | Descriptor: | 1,2-ETHANEDIOL, FORMIC ACID, MAGNESIUM ION, ... | | Authors: | Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) | | Deposit date: | 2009-10-27 | | Release date: | 2010-10-27 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate.
Biochimie, 93, 2011
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1EVK
 | | CRYSTAL STRUCTURE OF A TRUNCATED FORM OF THREONYL-TRNA SYNTHETASE WITH THE LIGAND THREONINE | | Descriptor: | THREONINE, THREONYL-TRNA SYNTHETASE, ZINC ION | | Authors: | Sankaranarayanan, R, Dock-Bregeon, A.C, Rees, B, Moras, D. | | Deposit date: | 2000-04-20 | | Release date: | 2000-07-19 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Zinc ion mediated amino acid discrimination by threonyl-tRNA synthetase.
Nat.Struct.Biol., 7, 2000
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7F6W
 | | Crystal structure of Saccharomyces cerevisiae lysyl-tRNA Synthetase | | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE, Lysine--tRNA ligase | | Authors: | Wu, S, Li, P, Hei, Z, Zheng, L, Wang, J, Fang, P. | | Deposit date: | 2021-06-26 | | Release date: | 2022-02-16 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.607 Å) | | Cite: | Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex.
Cell.Mol.Life Sci., 79, 2022
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7EVU
 | | Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with HFG and JE6 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, Prolyl-tRNA synthetase (ProRS), ... | | Authors: | Mishra, S, Malhotra, N, Manickam, Y, Sharma, A. | | Deposit date: | 2021-05-22 | | Release date: | 2022-03-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.697 Å) | | Cite: | Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development.
Plos Pathog., 18, 2022
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7EVV
 | | Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with JE6 and L-pro | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, PROLINE, ... | | Authors: | Malhotra, N, Mishra, S, Manickam, Y, Sharma, A. | | Deposit date: | 2021-05-22 | | Release date: | 2022-03-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.704 Å) | | Cite: | Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development.
Plos Pathog., 18, 2022
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2Q7E
 | | The structure of pyrrolysyl-tRNA synthetase bound to an ATP analogue | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Kavran, J.M, Steitz, T.A. | | Deposit date: | 2007-06-06 | | Release date: | 2007-07-24 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2PMF
 | | The crystal structure of a human glycyl-tRNA synthetase mutant | | Descriptor: | CHLORIDE ION, GLYCEROL, Glycyl-tRNA synthetase | | Authors: | Xie, W. | | Deposit date: | 2007-04-21 | | Release date: | 2007-05-22 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Long-range structural effects of a Charcot-Marie- Tooth disease-causing mutation in human glycyl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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4Q15
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1ZGH
 | | Methionyl-tRNA formyltransferase from Clostridium thermocellum | | Descriptor: | Methionyl-tRNA formyltransferase, UNKNOWN ATOM OR ION | | Authors: | Yang, H, Kataeva, I, Xu, H, Zhao, M, Chang, J, Liu, Z, Chen, L, Tempel, W, Habel, J, Zhou, W, Lee, D, Lin, D, Chang, S, Arendall III, W.B, Richardson, J.S, Richardson, D.C, Rose, J.P, Wang, B, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2005-04-21 | | Release date: | 2005-05-03 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Methionyl-tRNA formyltransferase from Clostridium thermocellum
To be published
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3IAL
 | | Giardia lamblia Prolyl-tRNA synthetase in complex with prolyl-adenylate | | Descriptor: | 5'-O-[(R)-hydroxy{[(2S)-pyrrolidin-2-ylcarbonyl]oxy}phosphoryl]adenosine, GLYCEROL, Prolyl-tRNA synthetase | | Authors: | Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) | | Deposit date: | 2009-07-14 | | Release date: | 2009-08-11 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.
Acta Crystallogr.,Sect.D, 68, 2012
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3P0I
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3QTC
 | | Crystal structure of the catalytic domain of MmOmeRS, an O-methyl tyrosyl-tRNA synthetase evolved from Methanosarcina mazei PylRS, complexed with O-methyl tyrosine and AMP-PNP | | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, O-methyl-L-tyrosine, ... | | Authors: | Dellas, N, Takimoto, J.K, Noel, J.P, Wang, L. | | Deposit date: | 2011-02-22 | | Release date: | 2011-05-25 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Stereochemical Basis for Engineered Pyrrolysyl-tRNA Synthetase and the Efficient in Vivo Incorporation of Structurally Divergent Non-native Amino Acids.
Acs Chem.Biol., 6, 2011
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3P0H
 | | Leishmania major Tyrosyl-tRNA synthetase in complex with fisetin, cubic crystal form | | Descriptor: | 3,7,3',4'-TETRAHYDROXYFLAVONE, Tyrosyl-tRNA synthetase | | Authors: | Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) | | Deposit date: | 2010-09-28 | | Release date: | 2011-03-23 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer.
J.Mol.Biol., 409, 2011
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3P0J
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1P4N
 | | Crystal Structure of Weissella viridescens FemX:UDP-MurNAc-pentapeptide complex | | Descriptor: | FemX, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Biarrotte-Sorin, S, Maillard, A, Delettre, J, Sougakoff, W, Arthur, M, Mayer, C. | | Deposit date: | 2003-04-23 | | Release date: | 2004-02-10 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures of Weissella viridescens FemX and its complex with UDP-MurNAc-pentapeptide: insights into FemABX family substrates recognition.
Structure, 12, 2004
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4CS4
 | | Catalytic domain of Pyrrolysyl-tRNA synthetase mutant Y306A, Y384F in complex with AMPPNP | | Descriptor: | 1,2-ETHANEDIOL, 2-{[dihydroxy(4-aminoethylphenyl)-{4}-sulfanyl]amino}-3-hydroxypropanoic acid, MAGNESIUM ION, ... | | Authors: | Schmidt, M.J, Weber, A, Pott, M, Welte, W, Summerer, D. | | Deposit date: | 2014-03-04 | | Release date: | 2014-04-30 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.349 Å) | | Cite: | Structural Basis of Furan-Amino Acid Recognition by a Polyspecific Aminoacyl-tRNA-Synthetase and its Genetic Encoding in Human Cells.
Chembiochem, 15, 2014
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1WLE
 | | Crystal Structure of mammalian mitochondrial seryl-tRNA synthetase complexed with seryl-adenylate | | Descriptor: | SERYL ADENYLATE, Seryl-tRNA synthetase | | Authors: | Chimnaronk, S, Jeppesen, M.G, Suzuki, T, Nyborg, J, Watanabe, K. | | Deposit date: | 2004-06-25 | | Release date: | 2005-09-06 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Dual-mode recognition of noncanonical tRNAs(Ser) by seryl-tRNA synthetase in mammalian mitochondria
Embo J., 24, 2005
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4CS2
 | | Catalytic domain of Pyrrolysyl-tRNA synthetase mutant Y306A, Y384F in its apo form | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PYRROLYSINE--TRNA LIGASE | | Authors: | Schmidt, M.J, Weber, A, Pott, M, Welte, W, Summerer, D. | | Deposit date: | 2014-03-04 | | Release date: | 2014-04-30 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Basis of Furan-Amino Acid Recognition by a Polyspecific Aminoacyl-tRNA-Synthetase and its Genetic Encoding in Human Cells.
Chembiochem, 15, 2014
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1WK9
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1SET
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1SES
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1TKE
 | | Crystal structure of the editing domain of threonyl-tRNA synthetase complexed with serine | | Descriptor: | SERINE, Threonyl-tRNA synthetase | | Authors: | Dock-Bregeon, A.C, Rees, B, Torres-Larios, A, Bey, G, Caillet, J, Moras, D. | | Deposit date: | 2004-06-08 | | Release date: | 2004-11-30 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Achieving Error-Free Translation; The Mechanism of Proofreading of Threonyl-tRNA Synthetase at Atomic Resolution.
Mol.Cell, 16, 2004
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