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6X8R
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BU of 6x8r by Molmil
Pharmacological characterisation and NMR structure of the novel mu-conotoxin SxIIIC, a potent irreversible NaV channel inhibitor
Descriptor: SxIIIC peptide
Authors:Schroeder, C.I, McMahon, K.L.
Deposit date:2020-06-01
Release date:2020-10-21
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Discovery, Pharmacological Characterisation and NMR Structure of the Novel μ-Conotoxin SxIIIC, a Potent and Irreversible Na V Channel Inhibitor.
Biomedicines, 8, 2020
7OW8
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BU of 7ow8 by Molmil
CryoEM structure of the ABC transporter BmrA E504A mutant in complex with ATP-Mg
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding/permease protein BmrA
Authors:Gobet, A, Schoehn, G, Falson, P, Chaptal, V.
Deposit date:2021-06-17
Release date:2022-01-19
Last modified:2022-02-02
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter.
Sci Adv, 8, 2022
1E3M
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BU of 1e3m by Molmil
The crystal structure of E. coli MutS binding to DNA with a G:T mismatch
Descriptor: 5'-D(*AP*GP*CP*TP*GP*CP*CP*AP*GP*GP*CP*AP*CP*CP*AP* GP*TP*GP*TP*CP*AP*GP*CP*GP*TP*CP*CP*TP*AP*T)-3', 5'-D(*AP*TP*AP*GP*GP*AP*CP*GP*CP*TP*GP*AP*CP*AP*CP* TP*GP*GP*TP*GP*CP*TP*TP*GP*GP*CP*AP*GP*CP*T)-3', ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Lamers, M.H, Perrakis, A, Enzlin, J.H, Winterwerp, H.H.K, De Wind, N, Sixma, T.K.
Deposit date:2000-06-19
Release date:2000-11-01
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Crystal Structure of DNA Mismatch Repair Protein Muts Binding to a G X T Mismatch
Nature, 407, 2000
1G63
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PEPTIDYL-CYSTEINE DECARBOXYLASE EPID
Descriptor: EPIDERMIN MODIFYING ENZYME EPID, FLAVIN MONONUCLEOTIDE
Authors:Blaesse, M, Kupke, T, Huber, R, Steinbac, S.
Deposit date:2000-11-03
Release date:2001-05-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the peptidyl-cysteine decarboxylase EpiD complexed with a pentapeptide substrate.
EMBO J., 19, 2000
1G5Q
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EPID H67N COMPLEXED WITH SUBSTRATE PEPTIDE DSYTC
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, EPIDERMIN MODIFYING ENZYME EPID, FLAVIN MONONUCLEOTIDE, ...
Authors:Blaesse, M, Kupke, T, Huber, R, Steinbacher, S.
Deposit date:2000-11-02
Release date:2001-05-02
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Crystal structure of the peptidyl-cysteine decarboxylase EpiD complexed with a pentapeptide substrate.
EMBO J., 19, 2000
2QBW
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BU of 2qbw by Molmil
The crystal structure of PDZ-Fibronectin fusion protein
Descriptor: PDZ-Fibronectin fusion protein, Polypeptide
Authors:Huang, J, Makabe, K, Koide, A, Koide, S.
Deposit date:2007-06-18
Release date:2008-04-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design of protein function leaps by directed domain interface evolution.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2XZP
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BU of 2xzp by Molmil
Upf1 helicase
Descriptor: GLYCEROL, MALONATE ION, REGULATOR OF NONSENSE TRANSCRIPTS 1
Authors:Chakrabarti, S, Jayachandran, U, Bonneau, F, Fiorini, F, Basquin, C, Domcke, S, Le Hir, H, Conti, E.
Deposit date:2010-11-26
Release date:2011-03-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and its Regulation by Upf2.
Mol.Cell, 41, 2011
2XZL
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Upf1-RNA complex
Descriptor: 5- R(*UP*UP*UP*UP*UP*UP*UP*UP*U) -3, ADENOSINE-5'-DIPHOSPHATE, ATP-DEPENDENT HELICASE NAM7, ...
Authors:Chakrabarti, S, Jayachandran, U, Bonneau, F, Fiorini, F, Basquin, C, Domcke, S, Le Hir, H, Conti, E.
Deposit date:2010-11-26
Release date:2011-03-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and its Regulation by Upf2.
Mol.Cell, 41, 2011
2XZO
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BU of 2xzo by Molmil
Upf1 helicase - RNA complex
Descriptor: 5'-R(*UP*UP*UP*UP*UP*UP*UP)-3', ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Chakrabarti, S, Jayachandran, U, Bonneau, F, Fiorini, F, Basquin, C, Domcke, S, Le Hir, H, Conti, E.
Deposit date:2010-11-26
Release date:2011-03-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.395 Å)
Cite:Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and its Regulation by Upf2.
Mol.Cell, 41, 2011
5MSN
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BU of 5msn by Molmil
Structure of the Dcc1 Protein
Descriptor: DCC1 protein
Authors:Wade, B.O, Singleton, M.R.
Deposit date:2017-01-05
Release date:2017-02-15
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Structural studies of RFC(C)(tf18) reveal a novel chromatin recruitment role for Dcc1.
EMBO Rep., 18, 2017
5MSM
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BU of 5msm by Molmil
Structure of the Dcc1-Ctf8-Ctf18C Trimer
Descriptor: Chromosome transmission fidelity protein 18, Chromosome transmission fidelity protein 8, Sister chromatid cohesion protein DCC1
Authors:Wade, B.O, Singleton, M.R.
Deposit date:2017-01-05
Release date:2017-02-15
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structural studies of RFC(C)(tf18) reveal a novel chromatin recruitment role for Dcc1.
EMBO Rep., 18, 2017
1I46
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BU of 1i46 by Molmil
The solution structure of the mutant stem loop C 5'GUA3' triloop of brome mosaic virus (+) strand RNA
Descriptor: 5'-R(*GP*GP*UP*GP*CP*GP*UP*AP*GP*CP*AP*CP*C)-3'
Authors:Kim, C.-H, Tinoco Jr, I.
Deposit date:2001-02-20
Release date:2001-04-21
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural and thermodynamic studies on mutant RNA motifs that impair the specificity between a viral replicase and its promoter
J.Mol.Biol., 307, 2001
1I4C
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BU of 1i4c by Molmil
THE SOLUTION STRUCTURE OF THE MINOR FAMILY OF THE MUTANT STEM LOOP C 5'UUA3' TRILOOP OF BROME MOSAIC VIRUS (+) STRAND RNA
Descriptor: RNA (5'-R(*GP*GP*UP*GP*CP*UP*UP*AP*GP*CP*AP*CP*C)-3')
Authors:Tinoco Jr, I, Kim, C.-H.
Deposit date:2001-02-20
Release date:2001-04-21
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural and thermodynamic studies on mutant RNA motifs that impair the specificity between a viral replicase and its promoter.
J.Mol.Biol., 307, 2001
1I4B
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BU of 1i4b by Molmil
The solution structure of the major family of the mutant stem loop C 5'UUA3' triloop of brome mosaic virus (+) strand RNA
Descriptor: 5'-R(*GP*GP*UP*GP*CP*UP*UP*AP*GP*CP*AP*CP*C)-3'
Authors:Tinoco Jr, I, Kim, C.-H.
Deposit date:2001-02-20
Release date:2001-04-21
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structural and thermodynamic studies on mutant RNA motifs that impair the specificity between a viral replicase and its promoter
J.Mol.Biol., 307, 2001
3WIP
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BU of 3wip by Molmil
Crystal structure of acetylcholine bound to Ls-AChBP
Descriptor: ACETATE ION, ACETYLCHOLINE, Acetylcholine-binding protein, ...
Authors:Olsen, J.A, Balle, T, Gajhede, M, Ahring, P.K, Kastrup, J.S.
Deposit date:2013-09-24
Release date:2014-04-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors
Plos One, 9, 2014
8DT8
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BU of 8dt8 by Molmil
LM18/Nb136 bispecific tetra-nanobody immunoglobulin in complex with SARS-CoV-2-6P-Mut7 S protein (focused refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, LM18 nanobody, Nb136 nanobody, ...
Authors:Ozorowski, G, Turner, H.L, Ward, A.B.
Deposit date:2022-07-25
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins.
Proc.Natl.Acad.Sci.USA, 120, 2023
5D8J
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BU of 5d8j by Molmil
Development of a therapeutic monoclonal antibody targeting secreted aP2 to treat type 2 diabetes.
Descriptor: Fatty acid-binding protein, adipocyte, HA3 Fab Heavy Chain, ...
Authors:Doyle, C, Birrane, G.
Deposit date:2015-08-17
Release date:2016-01-13
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (3 Å)
Cite:Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.
Sci Transl Med, 7, 2015
5IJ4
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BU of 5ij4 by Molmil
Solution structure of AN1-type zinc finger domain from Cuz1 (Cdc48 associated ubiquitin-like/zinc-finger protein-1)
Descriptor: CDC48-associated ubiquitin-like/zinc finger protein 1, ZINC ION
Authors:Sun, Z.-Y.J, Hanna, J, Wagner, G, Bhanu, M.K, Allan, M, Arthanari, H.
Deposit date:2016-03-01
Release date:2016-10-05
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution Structure of the Cuz1 AN1 Zinc Finger Domain: An Exposed LDFLP Motif Defines a Subfamily of AN1 Proteins.
Plos One, 11, 2016
5H72
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BU of 5h72 by Molmil
Structure of the periplasmic domain of FliP
Descriptor: Flagellar biosynthetic protein FliP
Authors:Fukumura, T, Kawaguchi, T, Saijo-Hamano, Y, Namba, K, Minamino, T, Imada, K.
Deposit date:2016-11-16
Release date:2017-08-02
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Assembly and stoichiometry of the core structure of the bacterial flagellar type III export gate complex
PLoS Biol., 15, 2017
6OMF
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BU of 6omf by Molmil
CryoEM structure of SigmaS-transcription initiation complex with activator Crl
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Jaramillo Cartagena, A, Darst, S.A, Campbell, E.A.
Deposit date:2019-04-18
Release date:2019-08-28
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.26 Å)
Cite:Structural basis for transcription activation by Crl through tethering of sigmaSand RNA polymerase.
Proc.Natl.Acad.Sci.USA, 116, 2019
6ODL
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BU of 6odl by Molmil
Crystal structure of GluN2A agonist binding domain with 4-butyl-(S)-CCG-IV
Descriptor: (1S,2R)-2-[(S)-amino(carboxy)methyl]-1-butylcyclopropane-1-carboxylic acid, Glutamate receptor ionotropic, NMDA 2A,Glutamate receptor ionotropic, ...
Authors:Mou, T.C, Clausen, R.P, Sprang, S.R, Hansen, K.B.
Deposit date:2019-03-26
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Stereoselective synthesis of novel 2'-(S)-CCG-IV analogues as potent NMDA receptor agonists.
Eur.J.Med.Chem., 212, 2021
6OQP
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BU of 6oqp by Molmil
U-AITx-Ate1
Descriptor: SER-LYS-TRP-ILE-CYS-ALA-ASN-ARG-SER-VAL-CYS-PRO-ILE
Authors:Elnahriry, K.A, Wai, D.C.C, Norton, R.S.
Deposit date:2019-04-28
Release date:2019-07-31
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa.
Toxicon, 168, 2019
4XHR
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BU of 4xhr by Molmil
Structure of a phospholipid trafficking complex, native
Descriptor: Mitochondrial distribution and morphology protein 35, Protein UPS1, mitochondrial
Authors:Yu, F, He, F, Wang, C, Zhang, P.
Deposit date:2015-01-06
Release date:2015-07-01
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex
Embo Rep., 16, 2015
4XIZ
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BU of 4xiz by Molmil
Structure of a phospholipid trafficking complex with substrate
Descriptor: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, Mitochondrial distribution and morphology protein 35, Protein UPS1, ...
Authors:Yu, F, He, F, Wang, C, Zhang, P.
Deposit date:2015-01-08
Release date:2015-07-01
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex
Embo Rep., 16, 2015
4XK9
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BU of 4xk9 by Molmil
Crystal structure of A-AChBP in complex with pinnatoxin G
Descriptor: CHLORIDE ION, Pinnatoxin G, Soluble acetylcholine receptor
Authors:Bourne, Y, Sulzenbacher, G, Marchot, P.
Deposit date:2015-01-10
Release date:2015-06-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal alpha 7 from Muscle alpha 12 beta gamma delta nAChRs.
Structure, 23, 2015

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