PDB: 235183 resultsInfo pagesStatus searchChemie searchBIRD

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3IWW	Crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DBIBzL, a urea-based inhibitor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Barinka, C, Lubkowski, J. Deposit date: 2009-09-03 Release date: 2009-11-24 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies. Bioorg.Med.Chem.Lett., 20, 2010
3IWX	Crystal structure of cisplatin bound to a human copper chaperone (dimer) Descriptor: Cisplatin, Copper transport protein ATOX1, SULFATE ION Authors: Boal, A.K, Rosenzweig, A.C. Deposit date: 2009-09-03 Release date: 2009-09-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Crystal structures of cisplatin bound to a human copper chaperone. J.Am.Chem.Soc., 131, 2009
3IWY	Crystal structure of human MDM2 complexed with D-peptide (12 residues) Descriptor: D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2 Authors: Pazgier, M, Lu, W. Deposit date: 2009-09-03 Release date: 2010-04-21 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.93 Å) Cite: D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms. Proc.Natl.Acad.Sci.USA, 398, 2010
3IWZ	The c-di-GMP Responsive Global Regulator CLP Links Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris Descriptor: Catabolite activation-like protein Authors: Chin, K.H, Tu, Z.L, Tseng, Y.H, Dow, J.M, Wang, A.H.J, Chou, S.H. Deposit date: 2009-09-03 Release date: 2009-12-15 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The cAMP receptor-like protein CLP is a novel c-di-GMP receptor linking cell-cell signaling to virulence gene expression in Xanthomonas campestris. J.Mol.Biol., 396, 2010
3IX0	Crystal structure of human seminal plasma protein PSP94 Descriptor: Beta-microseminoprotein Authors: Kumar, M, Kumar, A, Jagtap, D.D, Mahale, S.D. Deposit date: 2009-09-03 Release date: 2010-03-16 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of prostate secretory protein PSP94 shows an edge-to-edge association of two monomers to form a homodimer J.Mol.Biol., 397, 2010
3IX1	Periplasmic N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine binding protein from Bacillus halodurans Descriptor: N-[(4-amino-2-methylpyrimidin-5-yl)methyl]formamide, N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine binding protein Authors: Bale, S, Rajashankar, K.R, Perry, K, Begley, T.P, Ealick, S.E. Deposit date: 2009-09-03 Release date: 2010-10-13 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.4 Å) Cite: HMP Binding Protein ThiY and HMP-P Synthase THI5 Are Structural Homologues. Biochemistry, 49, 2010
3IX2	CRYSTAL STRUCTURE OF PURINE NUCLEOSIDE PHOSPHORYLASE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH ACYCLOVIR Descriptor: 9-HYROXYETHOXYMETHYLGUANINE, PHOSPHATE ION, Purine nucleoside phosphorylase Authors: de Azevedo Jr, W.F, Basso, L.A, Santos, D.S. Deposit date: 2009-09-03 Release date: 2021-07-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure and molecular dynamics studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis associated with acyclovir. Biochimie, 94, 2012
3IX3	LasR-OC12 HSL complex Descriptor: N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE, Transcriptional activator protein lasR Authors: Zou, Y, Nair, S.K. Deposit date: 2009-09-03 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.4 Å) Cite: LasR-OC12 HSL complex TO BE PUBLISHED
3IX4	LasR-TP1 complex Descriptor: 2,4-dibromo-6-({[(2-nitrophenyl)carbonyl]amino}methyl)phenyl 2-chlorobenzoate, Transcriptional activator protein lasR Authors: Zou, Y, Nair, S.K. Deposit date: 2009-09-03 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor. Chem.Biol., 16, 2009
3IX6	Crystal structure of Thymidylate synthase thyA from Brucella melitensis Descriptor: Thymidylate synthase Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2009-09-03 Release date: 2009-09-22 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of Thymidylate synthase thyA from Brucella melitensis To be Published
3IX7	Crystal structure of a domain of functionally unknown protein from Thermus thermophilus HB8 Descriptor: ACETIC ACID, Uncharacterized protein TTHA0540 Authors: Chang, C, Li, H, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) Deposit date: 2009-09-03 Release date: 2009-09-22 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Crystal structure of a domain of functionally unknown protein from Thermus thermophilus HB8 To be Published
3IX8	LasR-TP3 complex Descriptor: 2,4-dibromo-6-({[(2-chlorophenyl)carbonyl]amino}methyl)phenyl 2-methylbenzoate, Transcriptional activator protein lasR Authors: Zou, Y, Nair, S.K. Deposit date: 2009-09-03 Release date: 2009-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor. Chem.Biol., 16, 2009
3IX9	Crystal structure of Streptococcus pneumoniae dihydrofolate reductase - Sp9 mutant Descriptor: Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Yennawar, N.H. Deposit date: 2009-09-03 Release date: 2010-02-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Kinetic and structural characterization of dihydrofolate reductase from Streptococcus pneumoniae Biochemistry, 49, 2010
3IXA	Human Class I MHC HLA-A2(A150P) in complex with the Tax peptide Descriptor: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... Authors: Borbulevych, O.Y, Baker, B.M. Deposit date: 2009-09-03 Release date: 2010-01-12 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility. Immunity, 31, 2009
3IXB	X-ray crystal structure of the extended-spectrum AmpC E219K mutant beta-lactamase complexed with benzo(b)thiophene-2-boronic acid (BZB) at 1.63 Angstrom resolution Descriptor: BENZO[B]THIOPHENE-2-BORONIC ACID, Beta-lactamase, PHOSPHATE ION Authors: Shoichet, B.K, Thomas, V.L. Deposit date: 2009-09-03 Release date: 2010-02-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Structural bases for stability-function tradeoffs in antibiotic resistance. J.Mol.Biol., 396, 2010
3IXC	Crystal structure of hexapeptide transferase family protein from Anaplasma phagocytophilum Descriptor: Hexapeptide transferase family protein, MAGNESIUM ION Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2009-09-03 Release date: 2009-09-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Crystal structure of hexapeptide transferase family protein from Anaplasma phagocytophilum To be Published
3IXD	X-ray crystal structure of the extended-spectrum AmpC V298E mutant beta-lactamase at 2.64 Angstrom resolution Descriptor: Beta-lactamase, SULFATE ION Authors: Shoichet, B.K, Thomas, V.L. Deposit date: 2009-09-03 Release date: 2010-02-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.64 Å) Cite: Structural bases for stability-function tradeoffs in antibiotic resistance. J.Mol.Biol., 396, 2010
3IXE	Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase Descriptor: Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 2, ZINC ION Authors: Chiswell, B.P, Stiegler, A.L, Boggon, T.J, Calderwood, D.A. Deposit date: 2009-09-03 Release date: 2009-12-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase. J.Struct.Biol., 170, 2010
3IXF	Crystal Structure of Dehaloperoxidase B at 1.58 and Structural Characterization of the AB Dimer from Amphitrite ornata Descriptor: Dehaloperoxidase B, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... Authors: de Serrano, V.S, D'Antonio, J, Thompson, M.K, Franzen, S, Ghiladi, R.A. Deposit date: 2009-09-03 Release date: 2010-05-19 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Structure of dehaloperoxidase B at 1.58 A resolution and structural characterization of the AB dimer from Amphitrite ornata. Acta Crystallogr.,Sect.D, 66, 2010
3IXG	X-ray crystal structure of the extended-spectrum AmpC T70I mutant beta-lactamase with and without benzo(b)thiophene-2-boronic acid bound at 2.14 Angstrom resolution Descriptor: BENZO[B]THIOPHENE-2-BORONIC ACID, Beta-lactamase Authors: Shoichet, B.K, Thomas, V.L. Deposit date: 2009-09-04 Release date: 2010-02-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Structural bases for stability-function tradeoffs in antibiotic resistance. J.Mol.Biol., 396, 2010
3IXH	X-ray crystal structure of the extended-spectrum AmpC Y221G mutant beta-lactamase in complex with cefotaxime at 2.3 Angstrom resolution Descriptor: Beta-lactamase, CEFOTAXIME, C3' cleaved, ... Authors: Shoichet, B.K, Thomas, V.L. Deposit date: 2009-09-04 Release date: 2010-02-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural bases for stability-function tradeoffs in antibiotic resistance. J.Mol.Biol., 396, 2010
3IXJ	Crystal structure of beta-secretase 1 in complex with selective beta-secretase 1 inhibitor Descriptor: Beta-secretase 1, N-[4-(1-BENZYLCARBAMOYL-2-METHYL-PROPYLCARBAMOYL)-1-(3,5-DIFLUORO-PHENOXYMETHYL)-2-HYDROXY-4-METHOXY-BUTYL]-5-(METHANES ULFONYL-METHYL-AMINO)-N'-(1-PHENYLETHYL)-ISOPHTHALAMIDE, SULFATE ION Authors: Borkakoti, N, Lindberg, J, Nystrom, S. Deposit date: 2009-09-04 Release date: 2010-03-02 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Design and Synthesis of Potent and Selective BACE-1 Inhibitors. J.Med.Chem., 53, 2010
3IXK	Potent beta-secretase 1 inhibitor Descriptor: Beta-secretase 1, N-[(2S,3S,5R)-1-[(3,5-difluorophenyl)methoxy]-3-hydroxy-5-methyl-6-[[(2S)-3-methyl-1-oxo-1-(phenylmethylamino)butan-2-yl]amino]-6-oxo-hexan-2-yl]-5-(methyl-methylsulfonyl-amino)-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide Authors: Borkakoti, N, Lindberg, J.D, Nystrom, S. Deposit date: 2009-09-04 Release date: 2010-09-08 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core. Eur.J.Med.Chem., 45, 2010
3IXL	Crystal structure of the Gly74Cys-Cys188Ser mutant of arylmalonate decarboxylase in the liganded form Descriptor: 2-PHENYLACETIC ACID, Arylmalonate decarboxylase, GLYCEROL, ... Authors: Nakasako, M, Obata, R. Deposit date: 2009-09-04 Release date: 2010-02-23 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Structural Basis for Inverting the Enantioselectivity of Arylmalonate Decarboxylase Revealed by the Structural Analysis of the Gly74Cys/Cys188Ser Mutant in the Liganded Form Biochemistry, 49, 2010
3IXM	Structure of the Gly74Cys mutant of arylmalonate decarboxylase in the sulfate ion associated form Descriptor: Arylmalonate decarboxylase, SULFATE ION Authors: Nakasako, M, Obata, R. Deposit date: 2009-09-04 Release date: 2010-02-23 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Basis for Inverting the Enantioselectivity of Arylmalonate Decarboxylase Revealed by the Structural Analysis of the Gly74Cys/Cys188Ser Mutant in the Liganded Form Biochemistry, 49, 2010

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