3IWW

Crystal structure of human glutamate carboxypeptidase II (GCPII) in a complex with DBIBzL, a urea-based inhibitor

Summary for 3IWW

• Entry DOI: 10.2210/pdb3iww/pdb
• Descriptor: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: prostate specific membrane antigen; metallopeptidase; folate hydrolase; glutamate carboxypeptidase ii; naaladase; urea-based inhibitor, carboxypeptidase, cell membrane, dipeptidase, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, multifunctional enzyme, protease, signal-anchor, transmembrane
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm : Q04609
• Total number of polymer chains: 1
• Total formula weight: 83268.20

Authors

Barinka, C.,Lubkowski, J. (deposition date: 2009-09-03, release date: 2009-11-24, Last modification date: 2023-09-06)

• Primary citation: Wang, H.,Byun, Y.,Barinka, C.,Pullambhatla, M.,Bhang, H.E.,Fox, J.J.,Lubkowski, J.,Mease, R.C.,Pomper, M.G.; Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies.; Bioorg.Med.Chem.Lett., 20:392-397, 2010; PubMed: 19897367; DOI: 10.1016/j.bmcl.2009.10.061

Experimental method

X-RAY DIFFRACTION (2.3 Å)