3IXH

X-ray crystal structure of the extended-spectrum AmpC Y221G mutant beta-lactamase in complex with cefotaxime at 2.3 Angstrom resolution

Summary for 3IXH

Entry DOI	10.2210/pdb3ixh/pdb
Related	3IWI 3IWO 3IWQ 3IXB 3IXD 3IXG
Descriptor	Beta-lactamase, CEFOTAXIME, C3' cleaved, open, bound form (3 entities in total)
Functional Keywords	serine hydrolase, beta-lactamase, cephalosporinase, extended-spectrum antibiotic resistance, antibiotic resistance, hydrolase
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	79361.03
Authors	Shoichet, B.K.,Thomas, V.L. (deposition date: 2009-09-04, release date: 2010-02-16, Last modification date: 2024-02-21)
Primary citation	Thomas, V.L.,McReynolds, A.C.,Shoichet, B.K. Structural bases for stability-function tradeoffs in antibiotic resistance. J.Mol.Biol., 396:47-59, 2010 Cited by PubMed: 19913034 DOI: 10.1016/j.jmb.2009.11.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation