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7ABI
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BU of 7abi by Molmil
Human pre-Bact-2 spliceosome
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Beta-catenin-like protein 1, ...
Authors:Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
Deposit date:2020-09-07
Release date:2021-02-10
Method:ELECTRON MICROSCOPY (8 Å)
Cite:Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
7ABF
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BU of 7abf by Molmil
Human pre-Bact-1 spliceosome core structure
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
Deposit date:2020-09-07
Release date:2020-12-09
Last modified:2020-12-30
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
7AAV
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BU of 7aav by Molmil
Human pre-Bact-2 spliceosome core structure
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, D-chiro inositol hexakisphosphate, ...
Authors:Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R.
Deposit date:2020-09-04
Release date:2020-12-09
Last modified:2020-12-30
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
7JXV
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BU of 7jxv by Molmil
ANTH domain of CALM (clathrin-assembly lymphoid myeloid leukemia protein) bound to ubiquitin
Descriptor: Phosphatidylinositol-binding clathrin assembly protein, Ubiquitin
Authors:Pashkova, N, Gakhar, L, Schnicker, N.J, Piper, R.C.
Deposit date:2020-08-28
Release date:2021-08-04
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals.
Elife, 10, 2021
7JTP
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BU of 7jtp by Molmil
Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB
Descriptor: Elongin-B, Elongin-C, GLYCEROL, ...
Authors:Kottur, J, Jain, R, Aggarwal, A.K.
Deposit date:2020-08-18
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.
Sci Transl Med, 13, 2021
7JTO
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BU of 7jto by Molmil
Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB
Descriptor: 1,2-ETHANEDIOL, 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, Elongin-B, ...
Authors:Kottur, J, Jain, R, Aggarwal, A.K.
Deposit date:2020-08-18
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.
Sci Transl Med, 13, 2021
7JQC
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BU of 7jqc by Molmil
SARS-CoV-2 Nsp1, CrPV IRES and rabbit 40S ribosome complex
Descriptor: 40S ribosomal protein S21, 40S ribosomal protein S24, 40S ribosomal protein S26, ...
Authors:Yuan, S, Xiong, Y.
Deposit date:2020-08-10
Release date:2020-12-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA.
Mol.Cell, 80, 2020
7JQB
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BU of 7jqb by Molmil
SARS-CoV-2 Nsp1 and rabbit 40S ribosome complex
Descriptor: 40S ribosomal protein S21, 40S ribosomal protein S24, 40S ribosomal protein S26, ...
Authors:Yuan, S, Xiong, Y.
Deposit date:2020-08-10
Release date:2020-12-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA.
Mol.Cell, 80, 2020
7CPV
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BU of 7cpv by Molmil
Cryo-EM structure of 80S ribosome from mouse testis
Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S13, ...
Authors:Huo, Y.G, He, X, Jiang, T, Qin, Y, Guo, X.J, Sha, J.H.
Deposit date:2020-08-08
Release date:2022-02-02
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:A male germ-cell-specific ribosome controls male fertility.
Nature, 612, 2022
7CPU
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BU of 7cpu by Molmil
Cryo-EM structure of 80S ribosome from mouse kidney
Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S13, ...
Authors:Huo, Y.G, He, X, Jiang, T, Qin, Y, Guo, X.J, Sha, J.H.
Deposit date:2020-08-08
Release date:2022-02-02
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:A male germ-cell-specific ribosome controls male fertility.
Nature, 612, 2022
7A09
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BU of 7a09 by Molmil
Structure of a human ABCE1-bound 43S pre-initiation complex - State III
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Kratzat, H, Mackens-Kiani, T, Ameismeier, A, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R.
Deposit date:2020-08-07
Release date:2020-10-14
Last modified:2021-01-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes.
Embo J., 40, 2021
7A01
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BU of 7a01 by Molmil
The Halastavi arva virus intergenic region IRES promotes translation by the simplest possible initiation mechanism
Descriptor: 18S RIBOSOMAL RNA, 28S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN ES21, ...
Authors:Abaeva, I, Vicens, Q, Bochler, A, Soufari, H, Simonetti, A, Pestova, T.V, Hashem, Y, Hellen, C.U.T.
Deposit date:2020-08-05
Release date:2020-12-30
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The Halastavi arva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism.
Cell Rep, 33, 2020
7JMS
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BU of 7jms by Molmil
Structure of the Hazara virus OTU bound to ubiquitin
Descriptor: CALCIUM ION, GLYCEROL, Polyubiquitin-B, ...
Authors:Dzimianski, J.V, Pegan, S.D.
Deposit date:2020-08-02
Release date:2020-10-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Flipping the substrate preference of Hazara virus ovarian tumour domain protease through structure-based mutagenesis.
Acta Crystallogr D Struct Biol, 76, 2020
6ZXE
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BU of 6zxe by Molmil
Cryo-EM structure of a late human pre-40S ribosomal subunit - State F2
Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Ameismeier, M, Zemp, I, van den Heuvel, J, Thoms, M, Berninghausen, O, Kutay, U, Beckmann, R.
Deposit date:2020-07-29
Release date:2020-12-02
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for the final steps of human 40S ribosome maturation.
Nature, 587, 2020
6ZXF
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BU of 6zxf by Molmil
Cryo-EM structure of a late human pre-40S ribosomal subunit - State G
Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Ameismeier, M, Zemp, I, van den Heuvel, J, Thoms, M, Berninghausen, O, Kutay, U, Beckmann, R.
Deposit date:2020-07-29
Release date:2020-12-02
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis for the final steps of human 40S ribosome maturation.
Nature, 587, 2020
6ZXD
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BU of 6zxd by Molmil
Cryo-EM structure of a late human pre-40S ribosomal subunit - State F1
Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Ameismeier, M, Zemp, I, van den Heuvel, J, Thoms, M, Berninghausen, O, Kutay, U, Beckmann, R.
Deposit date:2020-07-29
Release date:2020-12-02
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis for the final steps of human 40S ribosome maturation.
Nature, 587, 2020
6ZXH
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BU of 6zxh by Molmil
Cryo-EM structure of a late human pre-40S ribosomal subunit - State H2
Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Ameismeier, M, Zemp, I, van den Heuvel, J, Thoms, M, Berninghausen, O, Kutay, U, Beckmann, R.
Deposit date:2020-07-29
Release date:2020-12-16
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for the final steps of human 40S ribosome maturation.
Nature, 587, 2020
6ZXG
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BU of 6zxg by Molmil
Cryo-EM structure of a late human pre-40S ribosomal subunit - State H1
Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Ameismeier, M, Zemp, I, van den Heuvel, J, Thoms, M, Berninghausen, O, Kutay, U, Beckmann, R.
Deposit date:2020-07-29
Release date:2020-12-02
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis for the final steps of human 40S ribosome maturation.
Nature, 587, 2020
6ZV6
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BU of 6zv6 by Molmil
Human RIO1(kd)-StHA late pre-40S particle, structural state B (post 18S rRNA cleavage)
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Plassart, L, Shayan, R, Plisson-Chastang, C.
Deposit date:2020-07-24
Release date:2021-05-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The final step of 40S ribosomal subunit maturation is controlled by a dual key lock.
Elife, 10, 2021
6ZUO
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BU of 6zuo by Molmil
Human RIO1(kd)-StHA late pre-40S particle, structural state A (pre 18S rRNA cleavage)
Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Plassart, L, Shayan, R, Plisson-Chastang, C.
Deposit date:2020-07-23
Release date:2021-05-12
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:The final step of 40S ribosomal subunit maturation is controlled by a dual key lock.
Elife, 10, 2021
6ZU9
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BU of 6zu9 by Molmil
Structure of a yeast ABCE1-bound 48S initiation complex
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ...
Authors:Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R.
Deposit date:2020-07-22
Release date:2020-10-28
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes.
Embo J., 40, 2021
6XQC
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BU of 6xqc by Molmil
UbKEKS
Descriptor: Polyubiquitin-B
Authors:Delattre, P, Letourneau, D, Lavigne, P, Roucou, X, Boisvert, F.M.
Deposit date:2020-07-09
Release date:2021-05-19
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Solution NMR structure of UbKEKS
To Be Published
7CJB
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BU of 7cjb by Molmil
VHL recognizes hydroxyproline in RIPK1
Descriptor: Elongin-B, Elongin-C, GLYCEROL, ...
Authors:Liu, J, Wang, Y, Pan, L.
Deposit date:2020-07-09
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:VHL recognizes hydroxyproline in RIPK1
To Be Published
6ZQH
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BU of 6zqh by Molmil
Yeast Uba1 in complex with ubiquitin
Descriptor: BETA-MERCAPTOETHANOL, GLYCEROL, TETRAETHYLENE GLYCOL, ...
Authors:Misra, M, Schindelin, H.
Deposit date:2020-07-09
Release date:2020-11-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.032 Å)
Cite:Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection.
Chemistry, 27, 2021
6ZP4
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BU of 6zp4 by Molmil
SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2
Descriptor: 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R.
Deposit date:2020-07-08
Release date:2020-07-29
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020

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