5GJQ
 
 | | Structure of the human 26S proteasome bound to USP14-UbAl | | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... | | Authors: | Huang, X.L, Luan, B, Wu, J.P, Shi, Y.G. | | Deposit date: | 2016-07-01 | | Release date: | 2016-08-17 | | Last modified: | 2019-11-06 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | An atomic structure of the human 26S proteasome.
Nat. Struct. Mol. Biol., 23, 2016
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6DJ9
 | | Structure of the USP15 DUSP domain in complex with a high-affinity Ubiquitin Variant (UbV) | | Descriptor: | Ubiquitin Variant UbV 15.D, Ubiquitin carboxyl-terminal hydrolase 15 | | Authors: | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | | Deposit date: | 2018-05-24 | | Release date: | 2019-01-23 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
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3PV1
 | | Crystal structure of the USP15 DUSP-UBL domains | | Descriptor: | ACETATE ION, Ubiquitin carboxyl-terminal hydrolase 15 | | Authors: | Elliott, P.R, Urbe, S, Clague, M.J, Barsukov, I.L. | | Deposit date: | 2010-12-06 | | Release date: | 2011-11-16 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural variability of the ubiquitin specific protease DUSP-UBL double domains.
Febs Lett., 585, 2011
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4MEL
 | | Crystal Structure of the human USP11 DUSP-UBL domains | | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 11 | | Authors: | Harper, S, Gratton, H.E, Cornaciu, I, Oberer, M, Scott, D.J, Emsley, J, Dreveny, I. | | Deposit date: | 2013-08-27 | | Release date: | 2014-05-07 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.899 Å) | | Cite: | Structure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like Domains.
Biochemistry, 53, 2014
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5CHV
 | | Crystal structure of USP18-ISG15 complex | | Descriptor: | CHLORIDE ION, SULFATE ION, Ubiquitin-like protein ISG15, ... | | Authors: | Fritz, G, Basters, A. | | Deposit date: | 2015-07-10 | | Release date: | 2016-09-28 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.005 Å) | | Cite: | Structural basis of the specificity of USP18 toward ISG15.
Nat. Struct. Mol. Biol., 24, 2017
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4A3O
 | | Crystal structure of the USP15 DUSP-UBL monomer | | Descriptor: | GLYCEROL, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 | | Authors: | Elliott, P.R, Liu, H, Pastok, M.W, Grossmann, G.J, Rigden, D.J, Clague, M.J, Urbe, S, Barsukov, I.L. | | Deposit date: | 2011-10-03 | | Release date: | 2011-11-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Variability of the Ubiquitin Specific Protease Dusp-Ubl Double Domains.
FEBS Lett., 585, 2011
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5CHT
 | | Crystal structure of USP18 | | Descriptor: | Ubl carboxyl-terminal hydrolase 18, ZINC ION | | Authors: | Fritz, G, Basters, A. | | Deposit date: | 2015-07-10 | | Release date: | 2016-06-29 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of the specificity of USP18 toward ISG15.
Nat. Struct. Mol. Biol., 24, 2017
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4A3P
 | | Structure of USP15 DUSP-UBL deletion mutant | | Descriptor: | ACETATE ION, IODIDE ION, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15 | | Authors: | Elliott, P.R, Liu, H, Pastok, M.W, Grossmann, G.J, Rigden, D.J, Clague, M.J, Urbe, S, Barsukov, I.L. | | Deposit date: | 2011-10-03 | | Release date: | 2011-11-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structural Variability of the Ubiquitin Specific Protease Dusp-Ubl Double Domains.
FEBS Lett., 585, 2011
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8OYP
 | | Crystal structure of Ubiquitin specific protease 11 (USP11) in complex with a substrate mimetic | | Descriptor: | CADMIUM ION, CHLORIDE ION, GLYCEROL, ... | | Authors: | Maurer, S.K, Caulton, S.G, Ward, S.J, Emsley, J, Dreveny, I. | | Deposit date: | 2023-05-05 | | Release date: | 2023-10-18 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Ubiquitin-specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity.
J.Biol.Chem., 299, 2023
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6CRN
 | | Structure of the USP15 deubiquitinase domain in complex with a high-affinity first-generation Ubv | | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.2, ZINC ION | | Authors: | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | | Deposit date: | 2018-03-19 | | Release date: | 2019-01-23 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
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3T9L
 | | Structure of N-terminal DUSP-UBL domains of human USP15 | | Descriptor: | SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 15 | | Authors: | Harper, S, Besong, T.M.D, Emsley, J, Scott, D.J, Dreveny, I. | | Deposit date: | 2011-08-03 | | Release date: | 2011-09-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure of the USP15 N-Terminal Domains: A beta-Hairpin Mediates Close Association between the DUSP and UBL Domains
Biochemistry, 50, 2011
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6CPM
 | | Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ... | | Authors: | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | | Deposit date: | 2018-03-13 | | Release date: | 2019-01-23 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.011 Å) | | Cite: | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
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6KHV
 | | Solution Structure of the CS2 Domain of USP19 | | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 19 | | Authors: | Xue, W, Hu, H.Y. | | Deposit date: | 2019-07-16 | | Release date: | 2020-07-22 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Domain interactions reveal auto-inhibition of the deubiquitinating enzyme USP19 and its activation by HSP90 in the modulation of huntingtin aggregation.
Biochem.J., 477, 2020
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6KQV
 | | Solution Structure of the UbL Domain of USP19 | | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 19 | | Authors: | Xue, W, Hu, H.Y. | | Deposit date: | 2019-08-19 | | Release date: | 2020-08-19 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Domain interactions reveal auto-inhibition of the deubiquitinating enzyme USP19 and its activation by HSP90 in the modulation of huntingtin aggregation.
Biochem.J., 477, 2020
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6LVS
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2I50
 | | Solution Structure of Ubp-M Znf-UBP domain | | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 16, ZINC ION | | Authors: | Pai, M.-T. | | Deposit date: | 2006-08-23 | | Release date: | 2007-08-07 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin.
J.Mol.Biol., 370, 2007
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6ML1
 | | Structure of the USP15 deubiquitinase domain in complex with an affinity-matured inhibitory Ubv | | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | | Deposit date: | 2018-09-26 | | Release date: | 2019-01-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Structure, 27, 2019
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2L80
 | | Solution Structure of the Zinc Finger Domain of USP13 | | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 13, ZINC ION | | Authors: | Zhang, Y, Zhou, C, Zhou, Z, Song, A, Hu, H. | | Deposit date: | 2010-12-28 | | Release date: | 2011-12-14 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Biochemical Characterization of the Ubiquitin Receptors in USP13 Reveals Different Catalytic Activation of Deubiquitination from Its Analogue USP5
To be Published
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2AYO
 | | Structure of USP14 bound to ubquitin aldehyde | | Descriptor: | Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 14 | | Authors: | Hu, M, Li, P, Jeffrey, P.D, Shi, Y. | | Deposit date: | 2005-09-07 | | Release date: | 2005-10-18 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
Embo J., 24, 2005
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2LBC
 | | solution structure of tandem UBA of USP13 | | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 13 | | Authors: | Zhang, Y, Zhou, C, Zhou, Z, Song, A, Hu, H. | | Deposit date: | 2011-03-29 | | Release date: | 2012-03-07 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Domain Analysis Reveals That a Deubiquitinating Enzyme USP13 Performs Non-Activating Catalysis for Lys63-Linked Polyubiquitin.
Plos One, 6, 2011
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2AYN
 | | Structure of USP14, a proteasome-associated deubiquitinating enzyme | | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 14 | | Authors: | Hu, M, Li, P, Jeffrey, P.D, Shi, Y. | | Deposit date: | 2005-09-07 | | Release date: | 2005-10-18 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
Embo J., 24, 2005
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5K1A
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5JJW
 | | Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain | | Descriptor: | 1,2-ETHANEDIOL, Squamous cell carcinoma antigen recognized by T-cells 3, UNKNOWN ATOM OR ION, ... | | Authors: | Dong, A, Zhang, Q, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC) | | Deposit date: | 2016-04-25 | | Release date: | 2016-05-04 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.01 Å) | | Cite: | Crystal structure of the HAT domain of sart3 in complex with USP15 DUSP-UBL domain
to be published
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5K1C
 | | Crystal structure of the UAF1/WDR20/USP12 complex | | Descriptor: | PHOSPHATE ION, TRIS(HYDROXYETHYL)AMINOMETHANE, Ubiquitin carboxyl-terminal hydrolase 12, ... | | Authors: | Li, H, D'Andrea, A.D, Zheng, N. | | Deposit date: | 2016-05-18 | | Release date: | 2016-07-20 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Mol.Cell, 63, 2016
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5K16
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