6CIT
 
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2H4M
 | | Karyopherin Beta2/Transportin-M9NLS | | Descriptor: | Heterogeneous nuclear ribonucleoprotein A1, Transportin-1 | | Authors: | Chook, Y.M, Cansizoglu, A.E. | | Deposit date: | 2006-05-24 | | Release date: | 2006-10-24 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Rules for nuclear localization sequence recognition by karyopherin beta 2.
Cell(Cambridge,Mass.), 126, 2006
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1Z3H
 | | The exportin Cse1 in its cargo-free, cytoplasmic state | | Descriptor: | Importin alpha re-exporter, MAGNESIUM ION | | Authors: | Cook, A, Fernandez, E, Lindner, D, Ebert, J, Schlenstedt, G, Conti, E. | | Deposit date: | 2005-03-12 | | Release date: | 2005-05-10 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | The structure of the nuclear export receptor cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding
Mol.Cell, 18, 2005
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7CYL
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1F59
 | | IMPORTIN-BETA-FXFG NUCLEOPORIN COMPLEX | | Descriptor: | FXFG NUCLEOPORIN REPEATS, IMPORTIN BETA-1 | | Authors: | Bayliss, R, Littlewood, T, Stewart, M. | | Deposit date: | 2000-06-13 | | Release date: | 2000-08-16 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.
Cell(Cambridge,Mass.), 102, 2000
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7B51
 | | Crystal structure of human CRM1 covalently modified by 2-mercaptoethanol at Cys528 | | Descriptor: | BETA-MERCAPTOETHANOL, Exportin-1, GTP-binding nuclear protein Ran, ... | | Authors: | Shaikhqasem, A, Ficner, R. | | Deposit date: | 2020-12-03 | | Release date: | 2021-03-10 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | Crystal structure of human CRM1, covalently modified by 2-mercaptoethanol on Cys528, in complex with RanGTP.
Acta Crystallogr.,Sect.F, 77, 2021
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7DBG
 | | Yeast CRM1e (apo) in complex with Ran-RanBP1 | | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, CRM1 isoform 1, ... | | Authors: | Sun, Q, Lei, Y. | | Deposit date: | 2020-10-20 | | Release date: | 2021-09-29 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin.
J.Nat.Prod., 84, 2021
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5J3V
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5JLJ
 | | Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1 | | Descriptor: | (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, CHLORIDE ION, Exportin-1, ... | | Authors: | Fung, H.Y, Chook, Y.M. | | Deposit date: | 2016-04-27 | | Release date: | 2016-06-29 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.
Leukemia, 30, 2016
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1IBR
 | | COMPLEX OF RAN WITH IMPORTIN BETA | | Descriptor: | GTP-binding nuclear protein RAN, Importin beta-1 subunit, MAGNESIUM ION, ... | | Authors: | Vetter, I.R, Arndt, A, Kutay, U, Goerlich, D, Wittinghofer, A. | | Deposit date: | 1999-05-14 | | Release date: | 1999-06-03 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural view of the Ran-Importin beta interaction at 2.3 A resolution
Cell(Cambridge,Mass.), 97, 1999
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1UKL
 | | Crystal structure of Importin-beta and SREBP-2 complex | | Descriptor: | Importin beta-1 subunit, Sterol regulatory element binding protein-2 | | Authors: | Lee, S.J, Sekimoto, T, Yamashita, E, Nagoshi, E, Nakagawa, A, Imamoto, N, Yoshimura, M, Sakai, H, Tsukihara, T, Yoneda, Y. | | Deposit date: | 2003-08-26 | | Release date: | 2003-12-09 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The Structure of Importin-beta Bound to SREBP-2: Nuclear Import of a Transcription Factor
Science, 302, 2003
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7CND
 | | NCI-1 in complex with CRM1-Ran-RanBP1 | | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, CRM1 isoform 1, ... | | Authors: | Sun, Q, Lei, Y. | | Deposit date: | 2020-07-31 | | Release date: | 2021-06-09 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure-Guided Design of the First Noncovalent Small-Molecule Inhibitor of CRM1.
J.Med.Chem., 64, 2021
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1WA5
 | | Structure of the Cse1:Imp-alpha:RanGTP complex | | Descriptor: | GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, Importin alpha re-exporter, ... | | Authors: | Stewart, M. | | Deposit date: | 2004-10-23 | | Release date: | 2004-12-13 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for the assembly of a nuclear export complex.
Nature, 432, 2004
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1M5N
 | | Crystal structure of HEAT repeats (1-11) of importin b bound to the non-classical NLS(67-94) of PTHrP | | Descriptor: | Importin beta-1 subunit, Parathyroid hormone-related protein | | Authors: | Cingolani, G, Bednenko, J, Gillespie, M.T, Gerace, L. | | Deposit date: | 2002-07-09 | | Release date: | 2003-01-21 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Molecular basis for the recognition
of a nonclassical nuclear localization
signal by importin beta
Mol.Cell, 10, 2002
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6XJR
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6XJU
 | | Crystal Structure of KPT-8602 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ) | | Descriptor: | (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ... | | Authors: | Baumhardt, J.M, Chook, Y.M. | | Deposit date: | 2020-06-24 | | Release date: | 2021-01-27 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.193 Å) | | Cite: | Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021
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6XJS
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2X19
 | | Crystal structure of Importin13 - RanGTP complex | | Descriptor: | GTP-BINDING NUCLEAR PROTEIN GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, IMPORTIN-13, ... | | Authors: | Bono, F, Cook, A.G, Gruenwald, M, Ebert, J, Conti, E. | | Deposit date: | 2009-12-23 | | Release date: | 2010-02-16 | | Last modified: | 2017-06-28 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Nuclear Import Mechanism of the Ejc Component Mago- Y14 Revealed by Structural Studies of Importin 13.
Mol.Cell, 37, 2010
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2X1G
 | | Crystal structure of Importin13 - Mago-Y14 complex | | Descriptor: | CADMUS, PROTEIN MAGO NASHI, RNA-BINDING PROTEIN 8A | | Authors: | Bono, F, Cook, A.G, Gruenwald, M, Ebert, J, Conti, E. | | Deposit date: | 2009-12-23 | | Release date: | 2010-02-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Nuclear Import Mechanism of the Ejc Component Mago- Y14 Revealed by Structural Studies of Importin 13.
Mol.Cell, 37, 2010
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3GJX
 | | Crystal Structure of the Nuclear Export Complex CRM1-Snurportin1-RanGTP | | Descriptor: | CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... | | Authors: | Monecke, T, Guettler, T, Neumann, P, Dickmanns, A, Goerlich, D, Ficner, R. | | Deposit date: | 2009-03-09 | | Release date: | 2009-05-26 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP.
Science, 2009
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3EA5
 | | Kap95p Binding Induces the Switch Loops of RanGDP to adopt the GTP-bound Conformation: Implications for Nuclear Import Complex Assembly Dynamics | | Descriptor: | GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, Importin subunit beta-1, ... | | Authors: | Forwood, J.K, Lonhienne, J.K, Guncar, G, Stewart, M, Marfori, M, Kobe, B. | | Deposit date: | 2008-08-24 | | Release date: | 2008-10-21 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: implications for nuclear import complex assembly dynamics.
J.Mol.Biol., 383, 2008
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4FDD
 | | Crystal structure of KAP beta2-PY-NLS | | Descriptor: | RNA-binding protein FUS, Transportin-1 | | Authors: | Zhang, Z.C, Chook, Y.M. | | Deposit date: | 2012-05-28 | | Release date: | 2012-07-18 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).
Proc.Natl.Acad.Sci.USA, 109, 2012
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4FQ3
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2XWU
 | | CRYSTAL STRUCTURE OF IMPORTIN 13 - UBC9 COMPLEX | | Descriptor: | IMPORTIN13, SUMO-CONJUGATING ENZYME UBC9 | | Authors: | Gruenwald, M, Bono, F. | | Deposit date: | 2010-11-05 | | Release date: | 2010-12-29 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of Importin13-Ubc9 Complex: Nuclear Import and Release of a Key Regulator of Sumoylation.
Embo J., 30, 2011
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2P8Q
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