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6W2J
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BU of 6w2j by Molmil
CPS1 bound to allosteric inhibitor H3B-374
Descriptor: (2-fluoranyl-4-methoxy-phenyl)-[(3~{R},5~{R})-4-(2-fluoranyl-4-methoxy-phenyl)carbonyl-3,5-dimethyl-piperazin-1-yl]methanone, 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], ...
Authors:Larsen, N.A, Nguyen, T.V.
Deposit date:2020-03-05
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1.
Acs Med.Chem.Lett., 11, 2020
1KEE
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BU of 1kee by Molmil
Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Carbamoyl-phosphate synthetase large chain, ...
Authors:Miles, B.W, Thoden, J.B, Holden, H.M, Raushel, F.M.
Deposit date:2001-11-15
Release date:2001-12-21
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin.
J.Biol.Chem., 277, 2002
5H80
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BU of 5h80 by Molmil
Biotin Carboxylase domain of single-chain bacterial carboxylase
Descriptor: 1,2-ETHANEDIOL, Carboxylase
Authors:Hagmann, A, Hunkeler, M, Stuttfeld, E, Maier, T.
Deposit date:2015-12-23
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Hybrid Structure of a Dynamic Single-Chain Carboxylase from Deinococcus radiodurans.
Structure, 24, 2016
6OI9
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BU of 6oi9 by Molmil
Crystal Structure of E. coli Biotin Carboxylase Complexed with 7-[3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine
Descriptor: 1,2-ETHANEDIOL, 7-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-2-amine, Biotin carboxylase
Authors:Andrews, L.D, Kane, T.R, Dozzo, P, Haglund, C.M, Hilderbrandt, D.J, Linsell, M.S, Machajewski, T, McEnroe, G, Serio, A.W, Wlasichuk, K.B, Neau, D.B, Pakhomova, S, Waldrop, G.L, Sharp, M, Pogliano, J, Cirz, R, Cohen, F.
Deposit date:2019-04-09
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.
J.Med.Chem., 62, 2019
6OI8
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BU of 6oi8 by Molmil
Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with 7-((1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl)-6-(2-chloro-6-(pyridin-3-yl)phenyl)pyrido[2,3-d]pyrimidin-2-amine
Descriptor: 1,2-ETHANEDIOL, 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-6-[2-chloro-6-(pyridin-3-yl)phenyl]pyrido[2,3-d]pyrimidin-2-amine, Biotin carboxylase
Authors:Andrews, L.D, Kane, T.R, Dozzo, P, Haglund, C.M, Hilderbrandt, D.J, Linsell, M.S, Machajewski, T, McEnroe, G, Serio, A.W, Wlasichuk, K.B, Neau, D.B, Pakhomova, S, Waldrop, G.L, Sharp, M, Pogliano, J, Cirz, R, Cohen, F.
Deposit date:2019-04-09
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.
J.Med.Chem., 62, 2019
7KCT
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BU of 7kct by Molmil
Crystal Structure of the Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase (OGC) Biotin Carboxylase (BC) Domain Dimer in Complex with Adenosine 5'-Diphosphate Magnesium Salt (MgADP), Adenosine 5'-Diphosphate (ADP, and Bicarbonate Anion (Hydrogen Carbonate/HCO3-)
Descriptor: 2-oxoglutarate carboxylase small subunit, ADENOSINE-5'-DIPHOSPHATE, BICARBONATE ION, ...
Authors:Buhrman, G.K, Rose, R.B, Enriquez, P, Truong, V.
Deposit date:2020-10-07
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase.
Biochemistry, 60, 2021
5I6I
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BU of 5i6i by Molmil
Crystal structure of a dBCCP-variant of Chaetomium thermophilum acetyl-CoA carboxylase
Descriptor: Acetyl-CoA carboxylase-like protein,Acetyl-CoA carboxylase-like protein,Acetyl-CoA carboxylase-like protein
Authors:Hunkeler, M, Stuttfeld, E, Hagmann, A, Imseng, S, Maier, T.
Deposit date:2016-02-16
Release date:2016-04-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (8.4 Å)
Cite:The dynamic organization of fungal acetyl-CoA carboxylase.
Nat Commun, 7, 2016
6OJH
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BU of 6ojh by Molmil
Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-aminopyrrolidin-1-yl)-6-(naphthalen-1-yl)pyrido[2,3-d]pyrimidin-2-amine
Descriptor: 7-[(3R)-3-aminopyrrolidin-1-yl]-6-(naphthalen-1-yl)pyrido[2,3-d]pyrimidin-2-amine, ACETATE ION, Biotin carboxylase, ...
Authors:Andrews, L.D, Kane, T.R, Dozzo, P, Haglund, C.M, Hilderbrandt, D.J, Linsell, M.S, Machajewski, T, McEnroe, G, Serio, A.W, Wlasichuk, K.B, Neau, D.B, Pakhomova, S, Waldrop, G.L, Sharp, M, Pogliano, J, Cirz, R, Cohen, F.
Deposit date:2019-04-11
Release date:2020-02-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of Haemophilus Influenzae Biotin Carboxylase Complexed with (R)-7-(3-aminopyrrolidin-1-yl)-6-(naphthalen-1-yl)pyrido[2,3-d]pyrimidin-2-amine
To Be Published
5I8I
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BU of 5i8i by Molmil
Crystal Structure of the K. lactis Urea Amidolyase
Descriptor: Urea Amidolyase
Authors:Zhao, J, Xiang, S.
Deposit date:2016-02-19
Release date:2017-04-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (6.5 Å)
Cite:Structure and function of urea amidolyase.
Biosci. Rep., 38, 2018
1W96
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BU of 1w96 by Molmil
Crystal Structure of Biotin Carboxylase Domain of Acetyl-coenzyme A Carboxylase from Saccharomyces cerevisiae in Complex with Soraphen A
Descriptor: ACETYL-COENZYME A CARBOXYLASE, SORAPHEN A
Authors:Shen, Y, Volrath, S.L, Weatherly, S.C, Elich, T.D, Tong, L.
Deposit date:2004-10-06
Release date:2005-01-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16, 2004
1W93
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BU of 1w93 by Molmil
Crystal Structure of Biotin Carboxylase Domain of Acetyl-Coenzyme A Carboxylase from Saccharomyces cerevisiae
Descriptor: ACETYL-COENZYME A CARBOXYLASE
Authors:Shen, Y, Volrath, S.L, Weatherly, S.C, Elich, T.D, Tong, L.
Deposit date:2004-10-05
Release date:2005-01-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Mechanism for the Potent Inhibition of Eukaryotic Acetyl-Coenzyme a Carboxylase by Soraphen A, a Macrocyclic Polyketide Natural Product
Mol.Cell, 16, 2004
7KC7
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BU of 7kc7 by Molmil
Biotin Carboxylase domain of Thermophilic 2-Oxoglutarate Carboxylase bound to ADP without Magnesium with disordered phosphate tail
Descriptor: 2-oxoglutarate carboxylase small subunit, ADENOSINE-5'-DIPHOSPHATE, PHOSPHATE ION
Authors:Buhrman, G.K, Rose, R.B, Enriquez, P, Truong, V.
Deposit date:2020-10-05
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase.
Biochemistry, 60, 2021
7KBL
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BU of 7kbl by Molmil
Biotin Carboxylase domain of Thermophilic 2-Oxoglutarate Carboxylase bound to Bicarbonate
Descriptor: 2-oxoglutarate carboxylase small subunit, BICARBONATE ION
Authors:Buhrman, G.K, Rose, R.B, Enriquez, P, Truong, V.
Deposit date:2020-10-02
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure, Function, and Thermal Adaptation of the Biotin Carboxylase Domain Dimer from Hydrogenobacter thermophilus 2-Oxoglutarate Carboxylase.
Biochemistry, 60, 2021
1ULZ
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BU of 1ulz by Molmil
Crystal structure of the biotin carboxylase subunit of pyruvate carboxylase
Descriptor: pyruvate carboxylase n-terminal domain
Authors:Kondo, S, Nakajima, Y, Sugio, S, Yong-Biao, J, Sueda, S, Kondo, H.
Deposit date:2003-09-18
Release date:2004-03-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the biotin carboxylase subunit of pyruvate carboxylase from Aquifex aeolicus at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 60, 2004
8SGZ
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BU of 8sgz by Molmil
Leishmania tarentolae propionyl-CoA carboxylase (alpha-6-beta-6)
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Propionyl-coa carboxylase beta chain, putative, ...
Authors:Lee, J.K.J, Liu, Y.T, Hu, J.J, Aphasizheva, I, Aphasizhev, R, Zhou, Z.H.
Deposit date:2023-04-13
Release date:2023-05-17
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:CryoEM reveals oligomeric isomers of a multienzyme complex and assembly mechanics.
J Struct Biol X, 7, 2023
8SGX
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BU of 8sgx by Molmil
Leishmania tarentolae propionyl-CoA carboxylase (alpha-4-beta-6)
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Propionyl-coa carboxylase beta chain, putative, ...
Authors:Lee, J.K.J, Liu, Y.T, Hu, J.J, Aphasizheva, I, Aphasizhev, R, Zhou, Z.H.
Deposit date:2023-04-13
Release date:2023-05-17
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (10.3 Å)
Cite:CryoEM reveals oligomeric isomers of a multienzyme complex and assembly mechanics.
J Struct Biol X, 7, 2023
8SGY
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BU of 8sgy by Molmil
Leishmania tarentolae propionyl-CoA carboxylase (alpha-5-beta-6)
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Propionyl-coa carboxylase beta chain, putative, ...
Authors:Lee, J.K.J, Liu, Y.T, Hu, J.J, Aphasizheva, I, Aphasizhev, R, Zhou, Z.H.
Deposit date:2023-04-13
Release date:2023-05-17
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (8.62 Å)
Cite:CryoEM reveals oligomeric isomers of a multienzyme complex and assembly mechanics.
J Struct Biol X, 7, 2023
8RTH
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BU of 8rth by Molmil
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase
Descriptor: 3-methylcrotonyl-CoA carboxylase, putative, 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ...
Authors:Ruiz, F.M, Plaza-Pegueroles, A, Fernandez-Tornero, C.
Deposit date:2024-01-26
Release date:2024-04-17
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.37 Å)
Cite:The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function.
Structure, 2024
8GK8
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BU of 8gk8 by Molmil
R21A Staphylococcus aureus pyruvate carboxylase
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, COENZYME A, ...
Authors:Laseke, A.J, St.Maurice, M.
Deposit date:2023-03-17
Release date:2023-08-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Allosteric Site at the Biotin Carboxylase Dimer Interface Mediates Activation and Inhibition in Staphylococcus aureus Pyruvate Carboxylase.
Biochemistry, 62, 2023
5CSK
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BU of 5csk by Molmil
Crystal structure of yeast acetyl-CoA carboxylase, unbiotinylated
Descriptor: Acetyl-CoA carboxylase
Authors:Wei, J, Tong, L.
Deposit date:2015-07-23
Release date:2015-10-28
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.
Nature, 526, 2015
2W6Q
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BU of 2w6q by Molmil
Crystal structure of Biotin carboxylase from E. coli in complex with the triazine-2,4-diamine fragment
Descriptor: 6-(2-phenoxyethoxy)-1,3,5-triazine-2,4-diamine, BIOTIN CARBOXYLASE, CHLORIDE ION
Authors:Mochalkin, I, Miller, J.R.
Deposit date:2008-12-18
Release date:2009-05-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches.
Acs Chem.Biol., 4, 2009
2W71
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BU of 2w71 by Molmil
Crystal structure of Biotin carboxylase from E. coli in complex with the imidazole-pyrimidine inhibitor
Descriptor: 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine, BIOTIN CARBOXYLASE, CHLORIDE ION
Authors:Mochalkin, I, Miller, J.R.
Deposit date:2008-12-19
Release date:2009-05-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches.
Acs Chem.Biol., 4, 2009
5CSL
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BU of 5csl by Molmil
Crystal structure of the 500 kD yeast acetyl-CoA carboxylase holoenzyme dimer
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Acetyl-CoA carboxylase, COENZYME A
Authors:Wei, J, Tong, L.
Deposit date:2015-07-23
Release date:2015-10-28
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.
Nature, 526, 2015
2W70
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BU of 2w70 by Molmil
Crystal structure of Biotin carboxylase from E. coli in complex with the amino-thiazole-pyrimidine fragment
Descriptor: 4-(2-amino-1,3-thiazol-4-yl)pyrimidin-2-amine, BIOTIN CARBOXYLASE, CHLORIDE ION
Authors:Mochalkin, I, Miller, J.R.
Deposit date:2008-12-19
Release date:2009-05-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches.
Acs Chem.Biol., 4, 2009
5DOT
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BU of 5dot by Molmil
Crystal Structure of Human Carbamoyl phosphate synthetase I (CPS1), apo form
Descriptor: 1,2-ETHANEDIOL, Carbamoyl-phosphate synthase [ammonia], mitochondrial, ...
Authors:Polo, L.M, de Cima, S, Fita, I, Rubio, V.
Deposit date:2015-09-11
Release date:2015-12-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of human carbamoyl phosphate synthetase: deciphering the on/off switch of human ureagenesis.
Sci Rep, 5, 2015

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