PDB: 108 resultsInfo pagesStatus searchChemie searchBIRD

---

6RT0	cryo-em structure of alpha-synuclein fibril polymorph 2A Descriptor: Alpha-synuclein Authors: Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. Deposit date: 2019-05-22 Release date: 2019-06-26 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
8FPT	STRUCTURE OF ALPHA-SYNUCLEIN FIBRILS DERIVED FROM HUMAN LEWY BODY DEMENTIA TISSUE Descriptor: Alpha-synuclein Authors: Barclay, A.M, Dhavale, D.D, Borcik, C.G, Rau, M.J, Basore, K, Milchberg, M.H, Warmuth, O.A, Kotzbauer, P.T, Rienstra, C.M, Schwieters, C.D. Deposit date: 2023-01-05 Release date: 2023-02-22 Last modified: 2024-05-15 Method: SOLID-STATE NMR Cite: Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue. Biorxiv, 2023
8H05	Minor polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient Descriptor: Alpha-synuclein Authors: Fan, Y, Sun, Y.P, Wang, J, Liu, C. Deposit date: 2022-09-28 Release date: 2022-11-30 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
8H03	Major polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a preclinical Parkinson's disease patient Descriptor: Alpha-synuclein Authors: Fan, Y, Sun, Y.P, Wang, J, Liu, C. Deposit date: 2022-09-28 Release date: 2022-11-30 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
8H04	Major polymorph in alpha-synuclein fibril seeded by cerebrospinal fluid from a postmortal Parkinson's disease patient Descriptor: Alpha-synuclein Authors: Fan, Y, Sun, Y.P, Wang, J, Liu, C. Deposit date: 2022-09-28 Release date: 2022-11-30 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (3 Å) Cite: Conformational change of alpha-synuclein fibrils in cerebrospinal fluid from different clinical phases of Parkinson's disease. Structure, 31, 2023
6SST	cryo-em structure of alpha-synuclein fibril polymorph 2B Descriptor: Alpha-synuclein Authors: Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. Deposit date: 2019-09-09 Release date: 2019-12-18 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
6SSX	cryo-em structure of alpha-synuclein fibril polymorph 2A Descriptor: Alpha-synuclein Authors: Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. Deposit date: 2019-09-09 Release date: 2019-12-18 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (2.98 Å) Cite: Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
6RTB	cryo-em structure of alpha-synuclein fibril polymorph 2B Descriptor: Alpha-synuclein Authors: Guerrero-Ferreira, R, Taylor, N.M.I, Arteni, A.A, Melki, R, Meier, B.H, Bockmann, A, Bousset, L, Stahlberg, H. Deposit date: 2019-05-22 Release date: 2019-06-26 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.46 Å) Cite: Two new polymorphic structures of human full-length alpha-synuclein fibrils solved by cryo-electron microscopy. Elife, 8, 2019
6OSM	Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-103 Descriptor: Alpha-synuclein Authors: Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L. Deposit date: 2019-05-01 Release date: 2019-09-25 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
6OSJ	Cryo-EM structure of the N-terminally acetylated full length alpha-synuclein fibrils (Ac1-140) Descriptor: Alpha-synuclein Authors: Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L. Deposit date: 2019-05-01 Release date: 2019-09-25 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
6OSL	Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-122 Descriptor: Alpha-synuclein Authors: Ni, X, McGlinchey, R.P, Jiang, J, Lee, J.C. Deposit date: 2019-05-01 Release date: 2019-09-25 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
6PES	Cryo-EM structure of alpha-synuclein H50Q Wide Fibril Descriptor: Alpha-synuclein Authors: Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. Deposit date: 2019-06-20 Release date: 2019-11-27 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
6PEO	Cryo-EM structure of alpha-synuclein H50Q Narrow Fibril Descriptor: Alpha-synuclein Authors: Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. Deposit date: 2019-06-20 Release date: 2019-11-27 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
8GF7	Cryo-EM structure of serine 87 O-GlcNAc-modified alpha-synuclein fibrils Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-synuclein Authors: Balana, J.A, Nguyen, A.B, Saelices, L, Pratt, R.M. Deposit date: 2023-03-07 Release date: 2023-11-08 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: O-GlcNAc forces an alpha-synuclein amyloid strain with notably diminished seeding and pathology. Nat.Chem.Biol., 20, 2024
7NCG	Type 2A alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.43 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCI	Type 2B alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.55 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCJ	Type 2AB alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (4.23 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCH	Type 1B alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 1 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCK	Type 3 alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 5 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.18 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
7NCA	Type 1A alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2 Descriptor: Alpha-synuclein Authors: Lovestam, S.K.A, Schweighauser, M, Scheres, S.H.W. Deposit date: 2021-01-28 Release date: 2021-02-24 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11, 2021
8HZC	Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-2) Descriptor: Alpha-synuclein Authors: Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. Deposit date: 2023-01-08 Release date: 2024-01-10 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-2) To Be Published
8HZB	Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-1) Descriptor: Alpha-synuclein Authors: Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. Deposit date: 2023-01-08 Release date: 2024-01-10 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Formed alpha-synuclein fibrils after incubation with heparin for 1 hour (Hep-remod-1) To Be Published
8HZS	Formed alpha-synuclein fibrils after incubation with heparin for 3 days (Hep-remod-3) Descriptor: Alpha-synuclein Authors: Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. Deposit date: 2023-01-09 Release date: 2024-01-10 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Formed alpha-synuclein fibrils after incubation with heparin for 3 days (Hep-remod-3) To Be Published
8JEX	Cryo-EM structure of alpha-synuclein gS87 fibril Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-synuclein, unverified amino acid chain Authors: Xia, W.C, Sun, Y.P, Liu, C. Deposit date: 2023-05-16 Release date: 2024-04-17 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures. Nat Commun, 15, 2024
8JEY	Cryo-EM structure of alpha-synuclein pS87 fibril Descriptor: Alpha-synuclein Authors: Xia, W.C, Sun, Y.P, Liu, C. Deposit date: 2023-05-16 Release date: 2024-04-17 Last modified: 2024-05-08 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Phosphorylation and O-GlcNAcylation at the same alpha-synuclein site generate distinct fibril structures. Nat Commun, 15, 2024

<12345>