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1SAN	THE DES(1-6)ANTENNAPEDIA HOMEODOMAIN: COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE DNA BINDING AFFINITY WITH THE INTACT ANTENNAPEDIA HOMEODOMAIN Descriptor: ANTENNAPEDIA PROTEIN Authors: Qian, Y.Q, Resendez-Perez, D, Gehring, W.J, Wuthrich, K. Deposit date: 1994-01-07 Release date: 1994-04-30 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: The des(1-6)antennapedia homeodomain: comparison of the NMR solution structure and the DNA-binding affinity with the intact Antennapedia homeodomain. Proc.Natl.Acad.Sci.USA, 91, 1994
3LNQ	Structure of Aristaless homeodomain in complex with DNA Descriptor: 5'-D(*CP*CP*CP*TP*AP*AP*TP*TP*AP*AP*AP*CP*CP*C)-3', 5'-D(*GP*GP*GP*TP*TP*TP*AP*AP*TP*TP*AP*GP*GP*G)-3', ACETATE ION, ... Authors: Takamura, Y, Miyazono, K, Nagata, K, Saigo, K, Kojima, T, Tanokura, M. Deposit date: 2010-02-02 Release date: 2010-04-28 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless Embo J., 29, 2010
6U81	Crystal Structure of the Double Homeodomain of DUX4 in Complex with a DNA aptamer Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*GP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*AP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*TP*GP*AP*TP*TP*AP*GP*CP*CP*CP*AP*TP*TP*AP*CP*GP*C)-3'), ... Authors: Shi, K, Aihara, H. Deposit date: 2019-09-04 Release date: 2020-02-19 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.34 Å) Cite: DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD. Faseb J., 34, 2020
7PSX	Structure of HOXB13 bound to hydroxymethylated DNA Descriptor: DNA (5'-D(P*GP*GP*AP*CP*CP*TP*5HCP*AP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*CP*GP*AP*GP*GP*TP*CP*C)-3'), Homeobox protein Hox-B13, ... Authors: Morgunova, E, Popov, A, Yin, Y, Taipale, J. Deposit date: 2021-09-24 Release date: 2022-10-05 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of HOXB13 bound to hydroxymethylated DNA To Be Published
7Q3O	Structure of CDX1 bound to hydroxymethylated DNA Descriptor: Homeobox protein CDX-1, hydroxymethylated DNA (18-MER) Authors: Morgunova, E, Yin, Y, Popov, A, Taipale, J. Deposit date: 2021-10-28 Release date: 2022-11-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.78 Å) Cite: Structure of CDX1 bound to hydroxymethylated DNA To Be Published
7Q4N	transcription factor CDX2 bound to hydroxymethylated DNA Descriptor: DNA (18-MER), Homeobox protein CDX-2 Authors: Morgunova, E, Yin, Y, Popov, A, Taipale, J. Deposit date: 2021-11-01 Release date: 2022-11-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (3.2 Å) Cite: transcription factor CDX2 bound to hydroxymethylated DNA To Be Published
8P7G	Structural characterization of PHOX2B and its DNA interactions shed lights into the molecular basis of the + 7Ala variant pathogenicity in CCHS Descriptor: Paired mesoderm homeobox protein 2B Authors: Russo, L, Diana, D, Fattorusso, R. Deposit date: 2023-05-30 Release date: 2024-05-15 Method: SOLUTION NMR Cite: Structural characterization of PHOX2B and its DNA interaction shed lights into the molecular basis of the + 7Ala variant pathogenicity in CCHS Chem Sci, 2024
5LUX	Homeobox transcription factor CDX1 bound to methylated DNA Descriptor: DNA (5'-D(P*GP*AP*GP*GP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*GP*GP*AP*GP*GP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*CP*CP*TP*C)-3'), ... Authors: Morgunova, E, Popov, A, Taipale, J. Deposit date: 2016-09-12 Release date: 2017-05-17 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (3.23 Å) Cite: Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017
5LTY	Homeobox transcription factor CDX2 bound to methylated DNA Descriptor: DNA (5'-D(P*GP*GP*AP*GP*GP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*CP*CP*TP*CP*C)-3'), Homeobox protein CDX-2 Authors: Morgunova, E, Popov, A, Taipale, J. Deposit date: 2016-09-07 Release date: 2017-05-31 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017
1UHS	Solution structure of mouse homeodomain-only protein HOP Descriptor: homeodomain only protein Authors: Saito, K, Koshiba, S, Inoue, M, Shirouzu, M, Terada, T, Yabuki, T, Aoki, M, Matsuda, T, Seki, E, Hirota, H, Yoshida, M, Tanaka, A, Osanai, T, Arakawa, T, Carninci, P, Kawai, J, Hayashizaki, Y, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2003-07-10 Release date: 2004-07-10 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Solution structure of mouse homeodomain-only protein HOP To be Published
3NAU	Crystal structure of ZHX2 HD2 (zinc-fingers and homeoboxes protein 2, homeodomain 2) Descriptor: SULFATE ION, Zinc fingers and homeoboxes protein 2 Authors: Ren, J, Bird, L.E, Owens, R.J, Stammers, D.K, Oxford Protein Production Facility (OPPF) Deposit date: 2010-06-02 Release date: 2010-07-07 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains Bmc Struct.Biol., 10, 2010
8F36	Ubx Homeodomain NMR solution structure Descriptor: Homeotic protein ultrabithorax Authors: Beasley, S.A, Loss, J.W, Mekkaoui, F, Advocate, M.R, Spratt, D.E. Deposit date: 2022-11-09 Release date: 2023-04-19 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Ubx Homeodomain NMR solution structure To Be Published
8F37	AbdA Homeodomain NMR Solution Structure Descriptor: Homeobox protein abdominal-A Authors: Beasley, S.A, Simons, R.A, Advocate, M.R, Mekkaoui, F, Spratt, D.E. Deposit date: 2022-11-09 Release date: 2023-04-19 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: AbdA Homeodomain NMR solution structure To Be Published
8BYX	HOXB13-homodimer bound to DNA Descriptor: DNA, Homeobox protein Hox-B13 Authors: Morgunova, E, Popov, A, Yin, Y, Taipale, J. Deposit date: 2022-12-14 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (3 Å) Cite: HOXB13-homodimer bound to DNA To Be Published
3NAR	Crystal structure of ZHX1 HD4 (zinc-fingers and homeoboxes protein 1, homeodomain 4) Descriptor: SULFATE ION, Zinc fingers and homeoboxes protein 1 Authors: Ren, J, Bird, L.E, Owens, R.J, Stammers, D.K, Oxford Protein Production Facility (OPPF) Deposit date: 2010-06-02 Release date: 2010-07-07 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains Bmc Struct.Biol., 10, 2010
3A03	Crystal structure of Hox11L1 homeodomain Descriptor: SODIUM ION, SULFATE ION, T-cell leukemia homeobox protein 2 Authors: Miyazono, K, Nagata, K, Saigo, K, Kojima, T, Tanokura, M. Deposit date: 2009-02-28 Release date: 2010-03-09 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless Embo J., 29, 2010
3A01	Crystal structure of Aristaless and Clawless homeodomains bound to DNA Descriptor: 5'-D(*CP*CP*GP*CP*AP*AP*TP*TP*AP*AP*TP*TP*AP*AP*GP*CP*C)-3', 5'-D(*GP*GP*CP*TP*TP*AP*AP*TP*TP*AP*AP*TP*TP*GP*CP*GP*G)-3', Homeobox protein aristaless, ... Authors: Miyazono, K, Nagata, K, Saigo, K, Kojima, T, Tanokura, M. Deposit date: 2009-02-28 Release date: 2010-03-09 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless Embo J., 29, 2010
3A02	Crystal structure of Aristaless homeodomain Descriptor: CADMIUM ION, CHLORIDE ION, Homeobox protein aristaless Authors: Miyazono, K, Nagata, K, Saigo, K, Kojima, T, Tanokura, M. Deposit date: 2009-02-28 Release date: 2010-03-09 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1 Å) Cite: Cooperative DNA-binding and sequence-recognition mechanism of aristaless and clawless Embo J., 29, 2010
1WI3	Solution structure of the homeodomain of KIAA1034 protein Descriptor: DNA-binding protein SATB2 Authors: Izumi, K, Yoshida, M, Hayashi, F, Hatta, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2004-05-28 Release date: 2004-11-28 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the homeodomain of KIAA1034 protein TO BE PUBLISHED
1X2M	Solution structure of the homeobox domain of mouse LAG1 longevity assurance homolog 6 Descriptor: LAG1 longevity assurance homolog 6 Authors: Kamatari, Y.O, Tomizawa, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) Deposit date: 2005-04-26 Release date: 2005-10-26 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure of the homeobox domain of mouse LAG1 longevity assurance homolog 6 To be Published
8ILW	Transcription factor LMX1a homeobox domain in complex with Pitx3 promoter Descriptor: DNA (5'-D(*CP*AP*AP*CP*AP*CP*TP*TP*AP*AP*TP*CP*CP*AP*AP*A)-3'), DNA (5'-D(*GP*TP*TP*TP*GP*GP*AP*TP*TP*AP*AP*GP*TP*GP*TP*T)-3'), LMX1A factor Authors: Lv, M.Q, Lin, L.Q. Deposit date: 2023-03-04 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (2.712 Å) Cite: Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain Febs J., 2024
8IKE	Transcription factors LMX1a mutant-R199A homeobox domain complex with Wnt1 promoter Descriptor: DNA (5'-D(*CP*CP*AP*TP*AP*TP*TP*TP*AP*AP*TP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*GP*AP*TP*TP*AP*AP*AP*TP*AP*TP*G)-3'), LMX1A factor Authors: Lv, M.Q, Lin, L.Q. Deposit date: 2023-02-28 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain Febs J., 2024
8IK5	Transcription factor LMX1a homeobox domain in complex with Wnt1 promoter Descriptor: DNA (5'-D(*CP*CP*AP*TP*AP*TP*TP*TP*AP*AP*TP*CP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*GP*AP*TP*TP*AP*AP*AP*TP*AP*TP*G)-3'), GLYCEROL, ... Authors: Lv, M.Q, Lin, L.Q. Deposit date: 2023-02-28 Release date: 2024-03-06 Method: X-RAY DIFFRACTION (1.989 Å) Cite: Structural insights into the recognition of the A/T-rich motif in target gene promoters by the LMX1a homeobox domain Febs J., 2024
1YRN	CRYSTAL STRUCTURE OF THE MATA1/MATALPHA2 HOMEODOMAIN HETERODIMER BOUND TO DNA Descriptor: DNA (5'-D(*TP*AP*CP*AP*TP*GP*TP*AP*AP*TP*TP*TP*AP*TP*TP*AP*C P*AP*TP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*GP*AP*TP*GP*TP*AP*AP*TP*AP*AP*AP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MAT A1 HOMEODOMAIN), ... Authors: Li, T, Stark, M.R, Johnson, A.D, Wolberger, C. Deposit date: 1995-11-02 Release date: 1996-01-29 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structure of the MATa1/MAT alpha 2 homeodomain heterodimer bound to DNA. Science, 270, 1995
5EF6	Structure of HOXB13 complex with methylated DNA Descriptor: DNA (5'-D(P*GP*GP*AP*CP*CP*TP*(5CM)P*GP*TP*AP*AP*AP*AP*CP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*GP*GP*TP*CP*C)-3'), Homeobox protein Hox-B13 Authors: Morgunova, E, Yin, Y, Jolma, A, Popov, A, Taipale, J. Deposit date: 2015-10-23 Release date: 2017-02-08 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3 Å) Cite: Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356, 2017

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