6U82

Crystal Structure of the Double Homeodomain of DUX4 in Complex with a DNA aptamer containing bulge and loop

Summary for 6U82

Entry DOI	10.2210/pdb6u82/pdb
Descriptor	Double homeobox protein 4, DNA (38-MER) (2 entities in total)
Functional Keywords	dux tandem homeodomains, dna binding protein-dna complex, dna binding protein/dna
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	54965.15
Authors	Shi, K.,Aihara, H. (deposition date: 2019-09-04, release date: 2020-02-19, Last modification date: 2023-10-11)
Primary citation	Klingler, C.,Ashley, J.,Shi, K.,Stiefvater, A.,Kyba, M.,Sinnreich, M.,Aihara, H.,Kinter, J. DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD. Faseb J., 34:4573-4590, 2020 Cited by PubMed: 32020675 DOI: 10.1096/fj.201902696 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.21 Å)

Structure validation