6U81

Crystal Structure of the Double Homeodomain of DUX4 in Complex with a DNA aptamer

Summary for 6U81

• Entry DOI: 10.2210/pdb6u81/pdb
• Descriptor: Double homeobox protein 4, DNA (5'-D(*GP*CP*GP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*AP*AP*CP*A)-3'), DNA (5'-D(*TP*GP*TP*TP*GP*AP*TP*TP*AP*GP*CP*CP*CP*AP*TP*TP*AP*CP*GP*C)-3'), ... (5 entities in total)
• Functional Keywords: dux tandem homeodomains, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 27033.31

Authors

Shi, K.,Aihara, H. (deposition date: 2019-09-04, release date: 2020-02-19, Last modification date: 2023-10-11)

• Primary citation: Klingler, C.,Ashley, J.,Shi, K.,Stiefvater, A.,Kyba, M.,Sinnreich, M.,Aihara, H.,Kinter, J.; DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD.; Faseb J., 34:4573-4590, 2020; PubMed: 32020675; DOI: 10.1096/fj.201902696

Experimental method

X-RAY DIFFRACTION (2.34 Å)