3NAU

Crystal structure of ZHX2 HD2 (zinc-fingers and homeoboxes protein 2, homeodomain 2)

Summary for 3NAU

• Entry DOI: 10.2210/pdb3nau/pdb
• Related: 3NAR
• Descriptor: Zinc fingers and homeoboxes protein 2, SULFATE ION (3 entities in total)
• Functional Keywords: zhx2, corepressor, homeodomain, domain swapping, structural genomics, oxford protein production facility, oppf, transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q9Y6X8
• Total number of polymer chains: 2
• Total formula weight: 16046.40

Authors

Ren, J.,Bird, L.E.,Owens, R.J.,Stammers, D.K.,Oxford Protein Production Facility (OPPF) (deposition date: 2010-06-02, release date: 2010-07-07, Last modification date: 2024-11-13)

Primary citation

Bird, L.E.,Ren, J.,Nettleship, J.E.,Folkers, G.E.,Owens, R.J.,Stammers, D.K.
Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains
Bmc Struct.Biol., 10:13-13, 2010

PubMed Abstract: Zhx1 to 3 (zinc-fingers and homeoboxes) form a set of paralogous genes encoding multi-domain proteins. ZHX proteins consist of two zinc fingers followed by five homeodomains. ZHXs have biological roles in cell cycle control by acting as co-repressors of the transcriptional regulator Nuclear Factor Y. As part of a structural genomics project we have expressed single and multi-domain fragments of the different human ZHX genes for use in structure determination.

PubMed: 20509910
DOI: 10.1186/1472-6807-10-13

Experimental method

X-RAY DIFFRACTION (2.7 Å)