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7O6R
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BU of 7o6r by Molmil
Crystal structure of bovine Hsc70(aa1-554)E213A/D214A in complex with 1H-Indazole
Descriptor: 1H-indazole, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ...
Authors:Zehe, M, Grimm, C, Sotriffer, C.
Deposit date:2021-04-12
Release date:2022-05-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct.
Acs Chem.Biol., 2024
7SQC
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BU of 7sqc by Molmil
Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CPC1, Calmodulin, ...
Authors:Gui, M, Wang, X, Dutcher, S.K, Brown, A, Zhang, R.
Deposit date:2021-11-05
Release date:2022-04-13
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Ciliary central apparatus structure reveals mechanisms of microtubule patterning.
Nat.Struct.Mol.Biol., 29, 2022
7Q4R
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BU of 7q4r by Molmil
Crystal structure of human HSP72-NBD in complex with fragment 1
Descriptor: 4-(4-phenyl-1,3-thiazol-2-yl)piperazine-1-carboxamide, Heat shock 70 kDa protein 1A, MAGNESIUM ION, ...
Authors:Le Bihan, Y.V, Westwood, I.M, van Montfort, R.L.M.
Deposit date:2021-11-02
Release date:2022-02-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70.
Molecules, 27, 2022
7OLC
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BU of 7olc by Molmil
Thermophilic eukaryotic 80S ribosome at idle POST state
Descriptor: 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ...
Authors:Kisonaite, M, Wild, K, Sinning, I.
Deposit date:2021-05-19
Release date:2022-01-26
Last modified:2022-04-06
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:High-resolution structures of a thermophilic eukaryotic 80S ribosome reveal atomistic details of translocation.
Nat Commun, 13, 2022
7N1R
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BU of 7n1r by Molmil
A novel and unique ATP hydrolysis to AMP by a human Hsp70 BiP
Descriptor: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, Endoplasmic reticulum chaperone BiP, ...
Authors:Yang, J, Musayev, F, Liu, Q.
Deposit date:2021-05-28
Release date:2022-01-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:A novel and unique ATP hydrolysis to AMP by a human Hsp70 Binding immunoglobin protein (BiP).
Protein Sci., 31, 2022
7KW7
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BU of 7kw7 by Molmil
Atomic cryoEM structure of Hsp90-Hsp70-Hop-GR
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Glucocorticoid receptor, Heat shock 70 kDa protein 1A, ...
Authors:Wang, R.Y, Noddings, C.M, Kirschke, E, Myasnikov, A, Johnson, J.L, Agard, D.A.
Deposit date:2020-11-30
Release date:2021-12-08
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism.
Nature, 601, 2022
7KRU
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BU of 7kru by Molmil
Stimulating state of a truncated Hsp70 DnaK fused with a substrate peptide
Descriptor: 1,3-PROPANDIOL, ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK fused with substrate peptide, ...
Authors:Wang, W, Hendrickson, W.A.
Deposit date:2020-11-20
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Conformational equilibria in allosteric control of Hsp70 chaperones.
Mol.Cell, 81, 2021
7KRT
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BU of 7krt by Molmil
Restraining state of a truncated Hsp70 DnaK
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, MAGNESIUM ION
Authors:Wang, W, Hendrickson, W.A.
Deposit date:2020-11-20
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Conformational equilibria in allosteric control of Hsp70 chaperones.
Mol.Cell, 81, 2021
7KRV
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BU of 7krv by Molmil
Stimulating state of disulfide-bridged Hsp70 DnaK
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK fused with substrate peptide, MAGNESIUM ION, ...
Authors:Wang, W, Hendrickson, W.A.
Deposit date:2020-11-20
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Conformational equilibria in allosteric control of Hsp70 chaperones.
Mol.Cell, 81, 2021
7KO2
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BU of 7ko2 by Molmil
Restraining state of near full-length Hsp70 DnaK
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK, MAGNESIUM ION, ...
Authors:Wang, W, Hendrickson, W.A.
Deposit date:2020-11-06
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Conformational equilibria in allosteric control of Hsp70 chaperones.
Mol.Cell, 81, 2021
7KRW
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BU of 7krw by Molmil
Stimulating state of near full-length Hsp70 DnaK fused with a substrate peptide
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK fused with substrate peptide
Authors:Wang, W, Hendrickson, W.A.
Deposit date:2020-11-20
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (7.7 Å)
Cite:Conformational equilibria in allosteric control of Hsp70 chaperones.
Mol.Cell, 81, 2021
7P31
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BU of 7p31 by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818
Descriptor: 4-IODOPYRAZOLE, AMP PHOSPHORAMIDATE, CHLORIDE ION, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-07-06
Release date:2021-07-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with small molecule ligands
To Be Published
7B80
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BU of 7b80 by Molmil
DeAMPylation complex of monomeric FICD and AMPylated BiP (state 2)
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
Authors:Perera, L.A, Ron, D.
Deposit date:2020-12-12
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.
Nat Commun, 12, 2021
7B7Z
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BU of 7b7z by Molmil
DeAMPylation complex of monomeric FICD and AMPylated BiP (state 1)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE MONOPHOSPHATE, Endoplasmic reticulum chaperone BiP, ...
Authors:Perera, L.A, Ron, D.
Deposit date:2020-12-12
Release date:2021-07-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD.
Nat Commun, 12, 2021
7N6M
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BU of 7n6m by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RQKPLLGLSR
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N6K
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BU of 7n6k by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RALALLPLSR
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N6J
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BU of 7n6j by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RKQSTIALALLPLLFTPRR
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
7N6L
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BU of 7n6l by Molmil
Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide EANQQKPLLGLFADG
Descriptor: Alkaline phosphatase peptide, Chaperone protein DnaK, GLYCEROL, ...
Authors:Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C.
Deposit date:2021-06-08
Release date:2021-06-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
7OOH
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BU of 7ooh by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818
Descriptor: 4-IODOPYRAZOLE, AMP PHOSPHORAMIDATE, CHLORIDE ION, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-05-27
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023818
To Be Published
7OOE
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BU of 7ooe by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z321318226
Descriptor: AMP PHOSPHORAMIDATE, CHLORIDE ION, GLYCEROL, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-05-27
Release date:2021-06-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.369 Å)
Cite:Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands
To Be Published
7OOG
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BU of 7oog by Molmil
Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023823
Descriptor: 4-bromanylpyridin-2-amine, AMP PHOSPHORAMIDATE, CHLORIDE ION, ...
Authors:Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I.
Deposit date:2021-05-27
Release date:2021-06-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with NCL-00023823
To Be Published
6W6E
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BU of 6w6e by Molmil
The Mycobacterium tuberculosis ClpB disaggregase hexamer structure with a locally refined ClpB middle domain and a DnaK nucleotide binding domain
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, Chaperone protein DnaK, ...
Authors:Yin, Y, Li, H.
Deposit date:2020-03-16
Release date:2021-05-26
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
Cell Rep, 35, 2021
7L6N
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BU of 7l6n by Molmil
The Mycobacterium tuberculosis ClpB disaggregase hexamer structure with three locally refined ClpB middle domains and three DnaK nucleotide binding domains
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, Chaperone protein DnaK, ...
Authors:Yin, Y.Y, Feng, X, Li, H.
Deposit date:2020-12-23
Release date:2021-05-26
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
Cell Rep, 35, 2021
7KZI
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BU of 7kzi by Molmil
Intermediate state (QQQ) of near full-length DnaK alternatively fused with a substrate peptide
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Chaperone protein DnaK fused with substrate peptide,Chaperone protein DnaK fused with substrate peptide, ...
Authors:Wang, W, Hendrickson, W.A.
Deposit date:2020-12-10
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Intermediates in allosteric equilibria of DnaK-ATP interactions with substrate peptides
Acta Crystallogr.,Sect.D, 77, 2021
7KZU
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BU of 7kzu by Molmil
Quasi-intermediate state (Q) of a truncated Hsp70 DnaK fused with a substrate peptide
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Chaperone protein DnaK fused with substrate peptide,Chaperone protein DnaK fused with substrate peptide, GLYCEROL, ...
Authors:Wang, W, Hendrickson, W.A.
Deposit date:2020-12-10
Release date:2021-05-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Intermediates in allosteric equilibria of DnaK-ATP interactions with substrate peptides
Acta Crystallogr.,Sect.D, 77, 2021

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PDB entries from 2024-06-12

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